Randomized Controlled Trial of the Effect of Bifidobacteria-Fermented Milk on Ulcerative Colitis

Ishikawa, Hideki; Akedo, Ikuko; Umesaki, Yoshinori; Tanaka, Ryuichiro; Imaoka, Akemi; Otani, Toru

doi:10.1080/07315724.2003.10719276

Cited by 326 publications

(199 citation statements)

References 22 publications

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“…ishikawa et al (ref. 30 ) reported that Bifidobacteria-fermented milk (BFm) supplementation reduces the luminal butyrate concentration, a key molecule in the remission of colitis. This reduction reflects the increased uptake or oxidation of scFas by the improved colorectal mucosa.…”

Section: Discussionmentioning

confidence: 99%

The long-term effects of probiotics in the therapy of ulcerative colitis: A clinical study

Palumbo¹,

Romeo²,

Gammazza³

et al. 2016

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

100

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Aim.Intestinal dysbiosis seems to be the leading cause of inflammatory bowel diseases, and probiotics seems to represent the proper support against their occurrence. Actually, probiotic blends and anti-inflammatory drugs represent a weapon against inflammatory bowel diseases. The present study evaluates the long-term (2 years) effects of combination therapy (mesalazine plus a probiotic blend of Lactobacillus salivarius, Lactobacillus acidophilus and Bifidobacterium bifidus strain BGN4) on ulcerative colitis activity. Method. Sixty patients with moderate-to-severe ulcerative colitis were enrolled: 30 of them were treated with a single daily oral administration of mesalazine 1200 mg; 30 patients received a single daily oral administration of mesalazine 1200 mg and a double daily administration of a probiotic blend of Lactobacillus salivarius, Lactobacillus acidophilus and Bifidobacterium bifidus strain BGN4. The treatment was carried out for two years and the clinical response evaluated according to the Modified Mayo Disease Activity Index. Results. All patients treated with combination therapy showed better improvement compared to the controls. In particular, the beneficial effects of probiotics were evident even after two years of treatment. Conclusions. A long-term treatment modality of anti-inflammatory drugs and probiotics is viable and could be an alternative to corticosteroids in mild-to moderate ulcerative colitis.

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Section: Discussionmentioning

confidence: 99%

The long-term effects of probiotics in the therapy of ulcerative colitis: A clinical study

Palumbo¹,

Romeo²,

Gammazza³

et al. 2016

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

100

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“…El estudio de Ishikawa y colaboradores en Japón mostró el éxito de esta conducta en el mantenimiento de la remisión, con una reducción significativa de las exacerbaciones, y posibles efectos preventivos en recaídas con el uso de un suplemento de leche fermentada con bifidobacteria (simbiótico) 100 mL/día durante 1 año en 41 pacientes. Hallazgo reafirmado en un nuevo estudio realizado por el mismo autor en 2011, con evidencia de mejoría clínica, colonoscópica y disminución de niveles de mieloperoxidasa en 21 pacientes (p <0,05) (42,43). En el mismo país, el estudio de Fujimori con 31 pacientes comparó Bifidobacterium longum 2 x 10 9 UFC y 8 g de psyllium (prebiótico) con simbiótico únicamente y encontró mayor impacto con manejo combinado, con remisión mantenida durante las 4 semanas de tratamiento (p=0,03) (44).…”

Section: Colitis Ulcerativaunclassified

Uso de probióticos en síndrome de intestino irritable y enfermedad inflamatoria intestinal: una revisión de la literatura

Gil-Tamayo

et al. 2017

Rev. Colomb. Gastroenterol.

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Introducción: El síndrome de intestino irritable (SII) y la enfermedad inflamatoria intestinal (EII), son motivos de consulta frecuente. Usualmente su tratamiento se hace en primer nivel de atención, con ajuste de estilo de vida y cambios dietarios. Los tratamientos farmacológicos tienen eficacia limitada e importantes efectos secundarios, por lo que existe un interés creciente en terapias diferentes como el uso de probióticos.Métodos: Se realizó una revisión de la literatura en las bases de datos Medline y Embase buscando estudios que asociaran suplementos nutricionales, con SII o EII, haciendo énfasis en probióticos.Resultados: De un total de 1598 referencias, 43 cumplieron criterios finales de inclusión. El uso de probióticos en SII y EII sugiere ser una terapia que ayuda a mantener los periodos de remisión de enfermedad, mejorar la calidad de vida y atenuar el proceso fisiopatológico.Conclusiones: El uso de probióticos y prebióticos podría ser una alternativa de soporte nutricional en pacientes seleccionados.

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“…A recent clinical trial demonstrated that treatment of patients with Bfdbm fermented milk compared to placebo leads to a significant decrease in a clinical activity index score, as well as a significant decrease in endoscopic and histological scores after 12 weeks of treatment [78].…”

Section: Probiotics To Treat Active Ucmentioning

confidence: 99%

Probiotics for Autoimmune Diseases: Is There a Benefit?

Özdemir¹,

Göksu-Erol²

2012

Contemporary Pediatrics

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Randomized Controlled Trial of the Effect of Bifidobacteria-Fermented Milk on Ulcerative Colitis

Abstract: Supplementation with the BFM product was successful in maintaining remission and had possible preventive effects on the relapse of ulcerative colitis.

Cited by 326 publications

References 22 publications

The long-term effects of probiotics in the therapy of ulcerative colitis: A clinical study

The long-term effects of probiotics in the therapy of ulcerative colitis: A clinical study

Uso de probióticos en síndrome de intestino irritable y enfermedad inflamatoria intestinal: una revisión de la literatura

Probiotics for Autoimmune Diseases: Is There a Benefit?

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