Randomized Intra-patient Controlled Trial of Mepilex Lite Dressings versus Aqueous Cream in Managing Radiation-Induced Skin Reactions Postmastectomy

Abstract

Objective: Severe acute radiation-induced skin reactions occur in a significant proportion of women who receive radiation therapy for breast cancer. We previously showed that Mepilex Lite dressings decreased the severity of erythema. Here we report their effect on the full range of skin reactions in 74 breast cancer patients post-mastectomy. Methods:A total of 80 women were recruited from four hospitals in New Zealand with 74 women contributing a full data set for analysis. The first skin area on the chest wall to develop erythema was randomly divided into two similar halves; one half was treated with Mepilex Lite dressings, the other half with aqueous cream. Skin reactions were assessed using the Radiation-Induced Skin Reaction Assessment Scale. Results:Compared with aqueous cream, Mepilex Lite dressings did not significantly reduce the incidence of moist desquamation but did reduce the overall severity of skin reactions by 41% (p<0.001), the average moist desquamation score by 49% (p=0.043) and the sum of the moist desquamation time for all patches by 28% from 25 to 18 weeks. Most patients preferred the dressings, found them easy to use and very comfortable to wear. Conclusions:Mepilex Lite dressings reduce all aspects of radiation-induced skin reactions.

Engaging patients with radiation related skin discomfort in self-care

“…Therefore, nursing management in follow-up nursing clinics is directed toward the palliation of skin reaction symptoms (Porock, 1999). Other reports have identified five management trials that examined a range of products (corticosteroid creams, sucralfate cream, hydrocolloid dressings, and a moisture vapor permeable dressing) (Paterson, 2012). Based on these results, no agent was found that significantly reduced the impact of acute radiation-induced skin reactions.…”

Double-Blind, Placebo-Controlled Pilot Study of Processed Ultra Emu Oil Versus Placebo in the Prevention of Radiation Dermatitis

“…It provides additional data in addition to provider-observed assessments that reflect the patient's lived experience. The Radiation-Induced Skin Reaction Assessment Scale (RIS-RAS) (22) also incorporates a professional assessment scale and a patient-rated symptom scale and has been used successfully to measure the observer-based and patient-based skin reaction in several recent trials (23)(24)(25)(26). Because the Skindex-16 does not include a professional assessment, the STAT was also used in this study.…”

Amnion Liofilisasi Efektif Menyembuhkan Reaksi Kulit Akibat Radioterapi Pada Pasien Kanker

“…2 Namun saat ini belum terdapat obat yang bisa menjadi standar dalam penanganan reaksi kulit. 7,8 Cara mempertahankan hidrasi kulit dengan mengunakan berbagai moisturizer, krim barrier, aloe vera, lanolin, dan krim steroids. 9, 10 Peter menemukan bahwa sekitar 77,5% pasien sembuh dengan pemberian salep dan kompres basah.…”