Randomized Phase III Study Comparing Preoperative Radiotherapy With Chemoradiotherapy in Nonresectable Rectal Cancer

Abstract

CRT improved local control, time to treatment failure, and cancer-specific survival compared with RT alone in patients with nonresectable rectal cancer. The treatments were well tolerated.

Inhibitory effects of oxaliplatin in experimental radiation treatment of colorectal carcinoma: does oxaliplatin improve 5-fluorouracil-dependent radiosensitivity?

“…Three randomized controlled trials have all concluded that the addition of 5-FU to adjuvant RT in LARC improves local control and increases respectability, but without influencing survival or rate of sphincter preservation (18,46,47), with the exception of one trial showing increased disease-free survival in the most advanced nonresectable cancers (18). Importantly, these studies also show increased but tolerable acute toxicity (14).…”

“…The locally advanced tumors constitute at least 50% of all rectal carcinomas including the primary non-resectable tumors which constitute about 10-15% of all cases (18).…”

Locally Advanced Rectal Cancer: What Is the Evidence for Induction Chemoradiation?

“…These data lend support to the view that CRT is more effective than RT. A recent abstract also supports the use of 5-FU-based CRT in this setting [30].…”

Neoadjuvant therapy for locally advanced rectal cancer

“…Зна-чимость неоадъювантного лечения показана в различных рандомизированных исследованиях, в которых были оп-тимизированы последовательность применения лекар-ственных препаратов, дозы лучевого воздействия и мето-дики хирургических вмешательств. Этот процесс растя-нулся более чем на три десятилетия [7,8].…”