Randomized Trial of Probiotics and Calcium on Diarrhea and Respiratory Tract Infections in Indonesian Children

Agustina, Rina; Kok, F.J.; Rest, Ondine van de; Fahmida, Umi; Firmansyah, Agus; Feskens, Edith J. M.; Heuvel, Ellen G. H. M. van den; Albers, Ruud; Bovee‐Oudenhoven, Ingeborg M. J.

doi:10.1542/peds.2011-1379

Cited by 92 publications

(76 citation statements)

References 41 publications

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“…Our study further provides support and confirmation of the findings of Agustina et al 9 with L reuteri DSM 17938 in Indonesian children where daily supplementation with this specific live bacterial strain also gave significant effect on the incidence of diarrhea, and further extends the finding to a different ethnic group of children. This allows analysis of multiple independent studies (present study, Weizman et al, 8 and Agustina et al 9 ) on the same intervention with similar protocols to establish evidence-based recommendations for the use of L reuteri DSM 17938 for the prevention of infectious disease in day care centers.…”

Section: Discussionsupporting

confidence: 90%

“…This allows analysis of multiple independent studies (present study, Weizman et al, 8 and Agustina et al 9 ) on the same intervention with similar protocols to establish evidence-based recommendations for the use of L reuteri DSM 17938 for the prevention of infectious disease in day care centers.…”

Section: Discussionmentioning

confidence: 97%

“…8 The incidence and duration of respiratory infections were unaltered by the intervention. 8 More recently, an RCT by Agustina et al 9 in Indonesian children (1-6 years old) reported that a 6-month supplementation with L reuteri DSM 17938 gave a significant absolute reduction (26%) of all reported diarrhea compared with placebo, with a stronger effect seen in malnourished children.…”

Section: Discussionmentioning

confidence: 99%

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Diarrhea in Preschool Children and Lactobacillus reuteri: A Randomized Controlled Trial

et al. 2014

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OBJECTIVES: To evaluate whether daily administration of Lactobacillus reuteri DSM 17938 reduces the frequency and duration of diarrheal episodes and other health outcomes in day school children in Mexico. METHODS: Healthy children (born at term, aged 6–36 months) attending day care centers were enrolled in this randomized, double-blind, placebo-controlled trial. They received L reuteri DSM 17938 (dose 108 colony-forming unit; n = 168) or identical placebo (n = 168) by mouth, daily for 3 months, after which they were followed-up after a further 3 months without supplementation. RESULTS: Data from all children were included in the final analysis. L reuteri DSM 17938 significantly reduced the frequency and duration of episodes of diarrhea and respiratory tract infection at both 3 and 6 months (P < .05). Additionally, the number of doctor visits, antibiotic use, absenteeism from day school and parental absenteeism from work were significantly reduced in the L reuteri group (P < .05). A cost-benefit analysis revealed significant reductions in costs in the L reuteri-treated children. No adverse events related to the study product were reported. CONCLUSIONS: In healthy children attending day care centers, daily administration of L reuteri DSM 17938 had a significant effect in reducing episodes and duration of diarrhea and respiratory tract infection, with consequent cost savings for the community.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Diarrhea in Preschool Children and Lactobacillus reuteri: A Randomized Controlled Trial

et al. 2014

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“…3,8,9 Large-scale randomized trials have provided relatively scant evidence (statistically significant but clinically controversial) of some probiotic strains, such as Lactobacillus rhamnosus, and some reuteri species and Bifidobacterium animalis in the prevention of acquired diarrhea in children. [10][11][12][13][14] However, few studies have been conducted in developing countries on the use of probiotics, as adjunctive therapy, in the treatment of acute diarrhea. 3 Hence, the present study aimed to determine the effect of probiotics, as an adjuvant therapy, on the treatment of diarrhea in children.…”

Section: Introductionmentioning

confidence: 99%

Effect of probiotic supplement (kidilact) on prevention of acute diarrhea in children: a double-blind randomized clinical trial

Hesaraki

2017

Int J Res Med Sci

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Background: Acute viral diarrhea is one of the most common diseases in children, which is associated with high risk of mortality. The present study aimed to determine the effect of Kidilact on the treatment of children with acute diarrhea.Methods: This double-blind randomized clinical trial was conducted on 84 children aged 6-60 months with diarrhea, hospitalized in pediatric ward of Amir al-Mu'minin hospital of Zabol, Iran. The patients who met the inclusion criteria were included and assigned to the control and treatment groups (42 patients in each group). Data collection instruments included clinical examination of participants in terms of gender, medication, diet, stool test, weight, average heart rate, average respiratory rate, average body temperature, and average frequency of defecation Data was analyzed with descriptive and analytical tests (chi-square, Fisher's exact test, t-test, etc.) in SPSS-21.Results: Body temperature, heart rate, and frequency of defecation significantly reduced in the intervention group after three days (p<0.05). In addition, weight gain presented an improving trend in the intervention group, but not significantly different from the control group (p<0.05).Conclusions: Findings indicated that the use of Kidilact may be helpful in the treatment of acute viral diarrhea in children and play a key role in early recovery, reduction of disease severity, and improvement of vital signs in these patients.

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“…Lower respiratory tract infection is the most commonly found in Indonesia (Wee-Ling 2010). Pneumonia is a common cause of morbidity and mortality among children under five years old (Agustina et al 2012). The two major diseases causing child mortality from ARI in Indonesia are pneumonia and bronchitis (Lipoeta, Wattanapenpaiboon & Wahlqvist 2004).…”

Section: Introductionmentioning

confidence: 99%

Development of the Quality of Nursing Care Scale for Hospitalized Acute Respiratory Infection Children in Indonesia

Suza¹,

Punthmatharith²,

Prateepchaikul³

2017

J. Ners

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Introduction: Acute respiratory infection in children leads to high morbidity and mortality. This is probably due to a lack of quality of care and no quality control. The Quality of Nursing Care for Hospitalized Ari Children (QNCS-HARIC) instrument is expected to be a potential tool for improving the quality of nursing practice with an approach more genuinely focused on parental involvement, especially in Indonesia. The purpose of this study is to develop a scale of QNCS-HARIC in Indonesia. Methods: Development of the QNCS-HARIC refers to a literature review, expert panel meeting, experts' review, and pilot study. Results: Four dimensions and 79 items were generated: 1) the physical needs of ARI children (36 items); 2) the psychological needs of ARI children and their families (26 items); 3) the socio-cultural needs of ARI children and their families (10 items) and 4) the spiritual needs of ARI children and their families (7 items). The validity was approved by five experts yielding a content validity index equalling .96. After performing the CVI, the QNCS-HARIC consisted of 78 items (deleting 2 items from the dimension on the physical needs of ARI children and an additional 1 item from the dimension on the physical needs of ARI children). The reliability was tested with 30 pediatric nurses yielding an alpha Cronbach's coefficient of the overall QNCS-HARIC 77 items of .94 and each of the dimensions equalled .94, .87, .79, and .73, respectively. Conclusion:To improve the quality of nursing care delivery, pediatric nurses need to be equipped with a quality instrument which should be psychometrically tested, sensitive, specific, accurate, objective, and feasible.

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Randomized Trial of Probiotics and Calcium on Diarrhea and Respiratory Tract Infections in Indonesian Children

Abstract: RC milk, alone or with L casei, did not reduce diarrhea or ARTIs in Indonesian children. L reuteri may prevent diarrhea, especially in children with lower nutritional status.

Cited by 92 publications

References 41 publications

Diarrhea in Preschool Children and Lactobacillus reuteri: A Randomized Controlled Trial

Diarrhea in Preschool Children and Lactobacillus reuteri: A Randomized Controlled Trial

Effect of probiotic supplement (kidilact) on prevention of acute diarrhea in children: a double-blind randomized clinical trial

Development of the Quality of Nursing Care Scale for Hospitalized Acute Respiratory Infection Children in Indonesia

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