Randomized trial of two doses of the prostaglandin E1 analog misoprostol for labor induction

Farah, Lisa; Sánchez-Ramos, Luis; Rosa, Cesar; Valle, Gerardo Del; Gaudier, Francisco L.; Delke, Isaac; Kaunitz, Andrew M.

doi:10.1016/s0002-9378(97)70199-6

Cited by 87 publications

(42 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The proportion of women delivering within the first twelve hours and next twelve hours of induction were similar among the groups, which is consistent with the finding by other investigators [14,17]. This is contrast to the finding of Meydanli et al [19] and Elhassan et al [17] Meydanli reported that more women delivered between 12-24 hours in the 25 µg group while El-hassan reported that fewer delivered vaginally in the 25 µg group.…”

Section: Discussionsupporting

confidence: 89%

“…There was no statistical significant difference between the two misoprostol regimens in terms of clinical efficacy. Although the study found that induction delivery interval was similar among the two groups, other investigators [13][14][15][16][17][18] had demonstrated that it was shorter in the 50 µg group. In a meta-analysis comparing 25 µg with 50 µg misoprostol, the induction vaginal delivery interval was nearly five hours shorter in the 50 µg group [19].…”

Section: Discussionmentioning

confidence: 67%

See 1 more Smart Citation

A Comparison of 25 μg with 50 μg Misoprostol for Cervical Ripening and Induction of Labor

Adebayo¹,

Onafowokan²,

Adewole³

2017

J Women's Health Care

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 67%

A Comparison of 25 μg with 50 μg Misoprostol for Cervical Ripening and Induction of Labor

Adebayo¹,

Onafowokan²,

Adewole³

2017

J Women's Health Care

View full text Add to dashboard Cite

show abstract

“…Wing and Paul (1998) in eht Department of Obstetrics and Gynecology, Women's and Children's Hospital, University of Southern California School of Medicine, Los Angeles 90033, USA, demonstrated that vaginal administration of misoprostol (Cytotec) is an effective alternative to oxytocin infusion for labor induction in women with premature rupture of the membranes near term (10). Farah et al (1997) in Department of Obstetrics and Gynecology, University of Florida Health Center , Jacksonville, USA demonstrated that although a dose of 50 µg is associated with a shorter start-to-delivery interval and a higher incidence of vaginal delivery after one dose. In our study, the latent phase was 4.3 ± 14 in the expectational treatment group and 2.6 ± 9.5 in misoprostol group.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of maternal and neonatal results after immediate labor induction by vaginal misoprostol and expectational treatment

Ghaleh¹

2012

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

Annual incidence of induced or strengthened labor in the United States, with nearly doubled increase, has risen from 20% in 1989 to 38% in 2002. For the success of labor induction, cervical status or its desirability is important. Different techniques are used to prepare the cervix. One of these techniques is using misoprostol tablets (Prostaglandin E1 (PGE1)). The aim of this study is to evaluate the maternal and neonatal results after immediate labor induction by vaginal misoprostol and expectational treatment. In a clinical trial conducted in Kosar hospital on 100 patients with diagnosis of premature rupture of the membranes (PROM) in 2006, the maternal and neonatal results that followed the immediate labor induction by vaginal misoprostol and expectational treatment for 12 h and then induction by oxytocin were investigated. The mean age of women was 23.8 ± 4.9 years in misoprostol group and 25.2 ± 5.6 years in the expectational treatment group (P = 0.197). The mean duration of pregnancy in women was 38.5 ± 1.2 weeks in misoprostol group and 38.5 ± 1.1 weeks in the expectational treatment group (P = 0.927). Mean parity of women was 1.74 ± 0.98 in misoprostol group and 1.56 ± 0.86 in the expectational treatment group (P = 0.333). The mean latency was 9.5 ± 2.6 in misoprostol group and 14 ± 4.3 expectational treatment group, which in misoprostol group was significantly less than that in the expectational treatment group (P < 0.000). The mean interval from peak recruitment contraction was 12.3 ± 2.9 in misoprostol group and 17.5 ± 4.9 in the expectational treatment group which in misoprostol group was significantly less than in the expectational treatment group (P < 0.000). Mean Apgar score in misoprostol group was significantly greater than that in the expectational treatment group (P = 0.02). The mean hospitalization duration of misoprostol group was significantly less than that of the expectational treatment group (P < 0.000). Frequency of vaginal delivery was 92% in the misoprostol group and 76% in the expectational treatment group; and the frequency of cesarean delivery was 8% in the misoprostol group and 24% in the expectational treatment group; so, frequency of cesarean delivery in the misoprostol group was significantly lower than that in the expectational treatment group (P < 0.029). Whereas labor induction by misoprostol shortens the duration of delivery and requires no long-term hospitalization and reduces costs for patient and hospital, its application is recommended in all low-risk patients. Since misoprostol reduces cesarean sections (CS) level, it is better to be used in low-risk women and this way, the risks of surgery and anesthesia risks related problems would be decreased. Also, regarding the fact that misoprostol, when compared with oxytocin, it administration requires no tight control and no individuals to constantly be on the clinical presence of the patient, it is more economical in terms of employment and need for medical personnel.

show abstract

“…Being a relati vely new drug for induction of labour, the researchers used different doses of misoprostol, varying from 50 micrograms 3 hourly to 25 micrograms 4-6 hourly in an attempt to find out the optimum dose [9,10]. In a pilot study before carrying out the present study we used 50 micrograms of misoprostol intravaginally 3 hourly but this was associated with higher number of precipitate labour, therefore we decided in favor of lower doses (25 micrograms/6 hourly).…”

Section: Discussionmentioning

confidence: 99%

Induction of Labour With Misoprostol – A Prostaglandin E1 Analogue

Kumar

Awasthi

Kapur

et al. 2001

Medical Journal Armed Forces India

View full text Add to dashboard Cite

The purpose of our stud y was to compare the safety and efficacy of intravaginal misoprostol versus existing hospital protocol of intracervical dinoprostone and oxytocin for cervical ripening and induction of labour. 200 patients with indication for induction of labour were randomly assigned to recei ve either intravaginal misoprostol or dinoprostone/oxytccin combination. In first group twenty five micrograms of misoprostol was placed intravaginally every 6 hours tiII the patient reached active stage of labour. In second group dinoprostone gel 0.5 mg was placed in the endocervix at night and oxytocin induction was started in the early morning. The average interval from start to induction of vaginal delivery was shorter in misoprostol group (1315±811 minutes) compared to dinoprostone/oxytocin group (1512±712 minutes) (p < 0.01) . There was no significant difference in route of delivery.18% of misoprostol treated patients and 23 % of dinoprostoneloxytocin treated patients required Caesarean section. Complications such as uterine tachysy stole were significantly higher in misoprostol group (p < 0.01 ) but it was not associated with increased incidence of uterine hyperstimulatiou. Perinatal outcome was similar in both groups. MJAFI 2001; 57 : 107·109

show abstract

Randomized trial of two doses of the prostaglandin E1 analog misoprostol for labor induction

Cited by 87 publications

References 12 publications

A Comparison of 25 μg with 50 μg Misoprostol for Cervical Ripening and Induction of Labor

A Comparison of 25 μg with 50 μg Misoprostol for Cervical Ripening and Induction of Labor

Evaluation of maternal and neonatal results after immediate labor induction by vaginal misoprostol and expectational treatment

Induction of Labour With Misoprostol – A Prostaglandin E1 Analogue

Contact Info

Product

Resources

About