Rapid analysis of melatonin in pharmaceutical tablets by capillary electrophoresis with UV detection

Cartoni, G.P.; Coccioli, F.; Jasionowska, Renata; Masci, Maurizio

doi:10.1007/bf02789759

Cited by 22 publications

(32 citation statements)

References 12 publications

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“…The range of physicochemical behaviour must be considered when determining sample handling strategies such as, for example, in pH control to ensure favourable partitioning behaviour during extraction [99]. Another example of a similar process has been reported [100]. In a recently published paper, two different methods were necessary for the complete quantification of phenolic compounds, a methanolic extraction and an extraction which included a SPE cleaning step [101].…”

Section: Solid-phase Extractionmentioning

confidence: 96%

Analytical determination of polyphenols in olive oils

Carrasco-Pancorbo

Cerretani

Bendini

et al. 2005

J of Separation Science

184

106

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The increasing popularity of olive oil is mainly attributed to its high content of oleic acid, which may affect the plasma lipid/lipoprotein profiles, and its richness in phenolic compounds, which act as natural antioxidants and may contribute to the prevention of human disease. An overview of analytical methods for the measurement of polyphenols in olive oil is presented. In principle, the analytical procedure for the determination of individual phenolic compounds in virgin olive oil involves three basic steps: extraction from the oil sample, analytical separation, and quantification. A great number of procedures for the isolation of the polar phenolic fraction of virgin olive oil, utilizing two basic extraction techniques, LLE or SPE, have been included. The reviewed techniques are those based on spectrophotometric methods, as well as analytical separation (gas chromatography (GC), high-performance liquid chromatography (HPLC), and capillary electrophoresis (CE)). Many reports in the literature determine the total amount of phenolic compounds in olive oils by spectrophometric analysis and characterize their phenolic patterns by capillary gas chromatography (CGC) and, mainly, by reverse phase high-performance liquid chromatography (RP-HPLC); however, CE has recently been applied to the analysis of phenolic compound of olive oil and has opened up great expectations, especially because of the higher resolution, reduced sample volume, and analysis duration. CE might represent a good compromise between analysis time and satisfactory characterization for some classes of phenolic compounds of virgin olive oils.

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Section: Solid-phase Extractionmentioning

confidence: 96%

Analytical determination of polyphenols in olive oils

Carrasco-Pancorbo

Cerretani

Bendini

et al. 2005

J of Separation Science

184

106

View full text Add to dashboard Cite

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“…GC has been used with three different detectors, FID [18], NMR [19], or MS [20][21][22]; in HPLC it is possible to find research works where UV (photodiode array) [23,24], fluorescence [25,26], electrochemical [27,28], biosensors [29], NMR [17], and MS [30][31][32][33] detectors are used, whilst CE has been used with UV as a detection system [10,34,35] and, more recently, MS detectors [36].…”

Section: Introductionmentioning

confidence: 99%

CE‐ and HPLC‐TOF‐MS for the characterization of phenolic compounds in olive oil

et al. 2007

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We present an easy and rapid method for the analysis of phenolic compounds in extra-virgin olive oil by CZE coupled with ESI-TOF-MS. Optimum electrophoretic separation was obtained using a basic carbonate electrolyte. We thus achieved the determination of several important families (phenyl alcohols, phenyl acids, lignans, flavonoids, and secoiridoids) of the polar fraction of the olive oil. Furthermore, other "unknown" compounds were also identified. In addition to the CZE method, HPLC analyses were made, separating compounds belonging to the main families present in this polyphenolic fraction, as well as other new compounds. We compared the results obtained with both techniques and found it was possible to determine more than 45 compounds with both methods. The sensitivity, together with mass accuracy and true isotopic pattern of the TOF-MS, allowed the identification of a broad series of known and so far not described phenolic compounds present in extra-virgin olive oil.

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“…An easy and accurate CE method with UV and amperometric detection was claimed for the dissolution testing of melatonin drug product (33,34). Flow-injection CE was recently developed by Karlberg's (35) and Fang's groups (36) independently.…”

Section: Capillary Electrophoresis (Ce)mentioning

confidence: 99%