Rapid and sensitive determination of doxorubicin in human whole blood by vertically-ordered mesoporous silica film modified electrochemically pretreated glassy carbon electrodes

Wang, Meifang; Lin, Jing; Gong, Jiawei; Ma, Mingchen; Tang, Hongliang; Liu, Jiyang; Yan, Fei

doi:10.1039/d0ra10000e

Cited by 24 publications

(20 citation statements)

References 55 publications

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“…Furthermore, the electrochemical sensors are considered to be more efficient and sensitive than other methods due to the opportunity to be boosted using various modifiers [ 26 , 27 , 28 , 29 ]. As a result of these considerations, numerous teams have reported electrochemically modified sensors for DOX monitoring [ 15 , 30 , 31 , 32 ]. However, the low selectivity issue is still one of the most important obstacles of electrochemical sensors for the detection of DOX.…”

Section: Introductionmentioning

confidence: 99%

Doxorubicin Anticancer Drug Monitoring by ds-DNA-Based Electrochemical Biosensor in Clinical Samples

2021

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In this research, glassy carbon electrode (GCE) amplified with single-wall carbon nanotubes (SWCNTs) and ds-DNA was fabricated and utilized for voltammetric sensing of doxorubicin with a low detection limit. In this technique, the reduction in guanine signal of ds-DNA in the presence of doxorubicin (DOX) was chosen as an analytical factor. The molecular docking study revealed that the doxorubicin drug interacted with DNA through intercalation mode, which was in agreement with obtained experimental results. The DOX detection performance of ds-DNA/SWCNTs/GCE was assessed at a concentration range of 1.0 nM–20.0 µM. The detection limit was found to be 0.6 nM that was comparable and even better (in many cases) than that of previous electrochemical reported sensors. In the final step, the ds-DNA/SWCNTs/GCE showed powerful ability for determination of the DOX in injection samples with acceptable recovery data.

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Section: Introductionmentioning

confidence: 99%

Doxorubicin Anticancer Drug Monitoring by ds-DNA-Based Electrochemical Biosensor in Clinical Samples

2021

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“…• • Antifouling layer [37,[61][62][63][64] • Size-selective sensing [68,69] • Charge-based sensing [54,63,70,71] • Hydrophobicity-based sensing [61,62,72] • Surface-grafting-based sensing [77][78][79] • Electron hopping-based sensing [68,82,83] attachment to electrodes, [34] and their nanopores were modified via amidation of the surface -COOH groups. [34,45]…”

Section: Mpsmentioning

confidence: 99%

Electrochemical sensing at nanoporous film‐coated electrodes

Ito

Nathani

2021

Electrochemical Science Adv

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“…On the one hand, a large number of silanol groups (Si-OH) with low pKa (∼2) endow the VMSF with a negatively charged surface, which can accelerate the transfer of positively charged molecules to the electrode surface, leading to a significant enrichment effect. On the other hand, ultrasmall nanochannels of the VMSF can exclude large-sized substances, which can effectively suppress the interference of coexisting substances in complex samples, providing high antifouling ability and good signal stability ( Yan et al, 2020a ; Yan et al, 2020b ; Lin et al, 2020 ; Liu et al, 2020 ; Ma et al, 2020 ; Yan et al, 2021a ; Wang et al, 2021b ; Yan et al, 2021b ; Qiu et al, 2021 ; Yanyan et al, 2021 ). Therefore, the VMSF has great potential in the development of facile ECL sensors for direct and sensitive analysis of antibiotics in complex samples.…”

Section: Introductionmentioning

confidence: 99%

A Flexible Electrochemiluminescence Sensor Equipped With Vertically Ordered Mesoporous Silica Nanochannel Film for Sensitive Detection of Clindamycin

Wei

et al. 2022

Front. Chem.

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Fast, convenient, and highly sensitive detection of antibiotic is essential to avoid its overuse and the possible harm. Owing to enrichment effect and antifouling ability of ultrasmall nanochannels, the vertically ordered mesoporous silica nanochannel film (VMSF) has great potential in the development of the facile electrochemiluminescence (ECL) sensor for direct and sensitive analysis of antibiotics in complex samples. In this study, we demonstrated a flexible ECL sensor based on a cost-effective electrode covered with a VMSF for sensitive detection of clindamycin. Polyethylene terephthalate coated with indium tin oxide (PET-ITO) is applied as a flexible electrode to grow VMSF using the electrochemically assisted self-assembly (EASA) method. The negatively charged VMSF nanochannels exhibit significant enrichment toward the commonly used cationic ECL luminophores, tris(2,2-bipyridyl) dichlororuthenium (II) (Ru (bpy)32+). Using the enhanced ECL of Ru (bpy)32+ by clindamycin, the developed VMSF/PET-ITO sensor can sensitively detect clindamycin. The responses were linear in the concentration range of 10 nM–25 μM and in the concentration range of 25–70 μM. Owing to the nanoscale thickness of the VMSF and the high coupling stability with the electrode substrate, the developed flexible VMSF/PET-ITO sensor exhibits high signal stability during the continuous bending process. Considering high antifouling characteristic of the VMSF, direct analysis of clindamycin in a real biological sample, human serum, is realized.

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Rapid and sensitive determination of doxorubicin in human whole blood by vertically-ordered mesoporous silica film modified electrochemically pretreated glassy carbon electrodes

Abstract: Direct and accurate detection of doxorubicin (DOX) in unprocessed human whole blood is of vital importance in medical diagnosis and monitoring.

Cited by 24 publications

References 55 publications

Doxorubicin Anticancer Drug Monitoring by ds-DNA-Based Electrochemical Biosensor in Clinical Samples

Doxorubicin Anticancer Drug Monitoring by ds-DNA-Based Electrochemical Biosensor in Clinical Samples

Electrochemical sensing at nanoporous film‐coated electrodes

A Flexible Electrochemiluminescence Sensor Equipped With Vertically Ordered Mesoporous Silica Nanochannel Film for Sensitive Detection of Clindamycin

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