Rapid corticosterone-induced impairment of amplectic clasping occurs in the spinal cord of roughskin newts (taricha granulosa)

Lewis, Christine M.; Rose, James D.

doi:10.1016/s0018-506x(02)00019-3

Cited by 25 publications

(5 citation statements)

References 18 publications

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“…Adrenal glucocorticoids exert powerful and rapid actions on reproductive clasping in roughskin newts. This suppression occurs even in spinally transected newts (Lewis and Rose, 2003), consistent with an interaction with a CPG (the exact neural locus is currently undefined). Second, a CPG that governs oxytocin release from the hypothalamus is responsive to long-term steroid actions, and these actions appear to drive sex differences in the bursting membrane properties of oxytocinergic neurons (Israel et al, 2014).…”

Section: Do Steroids Behave Like Neuromodulators?mentioning

confidence: 79%

Frank Beach Award Winner: Steroids as neuromodulators of brain circuits and behavior

Remage‐Healey

2014

Hormones and Behavior

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Neurons communicate primarily via action potentials that transmit information on the timescale of milliseconds. Neurons also integrate information via alterations in gene transcription and protein translation that are sustained for hours to days after initiation. Positioned between these two signaling timescales are the minute-by-minute actions of neuromodulators. Over the course of minutes, the classical neuromodulators (such as serotonin, dopamine, octopamine, and norepinephrine) can alter and/or stabilize neural circuit patterning as well as behavioral states. Neuromodulators allow many flexible outputs from neural circuits and can encode information content into the firing state of neural networks. The idea that steroid molecules can operate as genuine behavioral neuromodulators - synthesized by and acting within brain circuits on a minute-by-minute timescale - has gained traction in recent years. Evidence for brain steroid synthesis at synaptic terminals has converged with evidence for the rapid actions of brain-derived steroids on neural circuits and behavior. The general principle emerging from this work is that the production of steroid hormones within brain circuits can alter their functional connectivity and shift sensory representations by enhancing their information coding. Steroids produced in the brain can therefore change the information content of neuronal networks to rapidly modulate sensory experience and sensorimotor functions.

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Section: Do Steroids Behave Like Neuromodulators?mentioning

confidence: 79%

Frank Beach Award Winner: Steroids as neuromodulators of brain circuits and behavior

Remage‐Healey

2014

Hormones and Behavior

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“…Moore and colleagues first presented evidence for high-affinity membrane corticosteroid receptors in the salamander brain over ten years ago (Orchinik et al, 1991), and these receptors have since been detected in the brains of several other species of amphibians (Moore et al, 1995;Orchinik et al, 2000) and birds (Breuner and Orchinik, 2001). Brain membrane corticosteroid receptors have been studied primarily in medullary neurons that control male reproductive behavior in the newt (Rose et al, 1993), although they have been detected in other areas of the central nervous system as well Rose, 2002: Lewis andRose, 2003). Interestingly, the membrane glucocorticoid receptors in house sparrows undergo seasonal changes in expression that could be responsible for seasonal variability in the stress response (Wingfeld et al, 1992).…”

Section: Rapid Glucocorticoid Actions In the Brainmentioning

confidence: 99%

Rapid Central Corticosteroid Effects: Evidence for Membrane Glucocorticoid Receptors in the Brain

Tasker

Shi

Malcher‐Lopes

2005

Integrative and Comparative Biology

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Glucocorticoid secretion occurs in a circadian pattern and in response to stress. Among the broad array of glucocorticoid actions are multiple effects in the brain, including negative feedback regulation of hypothalamic hormone secretion. The negative feedback of glucocorticoids occurs on both rapid and delayed time scales, reflecting different regulatory mechanisms. While the slow glucocorticoid effects are widely held to involve regulation of gene transcription, the rapid effects are too fast to invoke genomic mechanisms. We provide a brief overview of multiple lines of evidence for membrane-associated glucocorticoid receptors in the brain, with an emphasis on our recent findings of a rapid, G protein-dependent glucocorticoid action in the rat hypothalamus. We have observed a novel mechanism of rapid glucocorticoid inhibition of parvocellular neuroendocrine cells of the hypothalamic paraventricular nucleus (PVN) mediated by the retrograde release of endocannabinoids and suppression of synaptic glutamate release. This acute glucocorticoid action may underlie the rapid inhibitory effect of glucocorticoids on hypothalamic neuroendocrine function, and provides a potential model for the rapid glucocorticoid effects that occur in several areas of the brain.

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“…Medullary AVT application enhances neuronal responses to cloacal stimulation, a clasp‐triggering stimulus (Rose et al, 1995). This AVT effect is significant because, although clasping is generated by the spinal cord in Taricha (Lewis and Rose, 2003a), medullary reticular neurons, including reticulospinal neurons, the primary brainstem projections to the spinal cord (ten Donkelaar, 1982; Naujoks‐Manteuffel and Manteuffel, 1988; ten Donkelaar, 1998), appear to play a key role in controlling clasp strength and duration (Rose et al, 1998; Rose and Moore, 2002).…”

mentioning

confidence: 99%

Identification of roughskin newt medullary vasotocin target neurons with a fluorescent vasotocin conjugate

Lewis

Dolence

Hubbard

et al. 2005

J of Comparative Neurology

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Arginine8 vasotocin (AVT), a neurohypophyseal peptide in nonmammalian vertebrates, plays a key role in the regulation of social behaviors related to reproduction. In male roughskin newts (Taricha granulosa), AVT is an important facilitator of several reproductive behaviors, including courtship clasping of females. Although AVT is known to act in certain brain regions and AVT receptors have been localized to some extent, specific target neurons for this peptide have not been identified in any species. Internalization of a receptor-specific conjugate of AVT and the fluorescent dye Oregon green was used to identify AVT target cells in the medulla of male roughskin newts. Medullary neurons are of interest because they appear to mediate facilitation of clasping by AVT. Direct application of AVT-Oregon green to the fourth ventricular surface of the medulla in vivo resulted in conjugate internalization by a widespread population of medullary neurons, particularly in the medial reticular formation and nuclei of cranial nerves V, VII, VIII, IX, and X. Some fourth-ventricle ependymal cells were also labeled. Reticulospinal neurons, which play an important role in clasping, were identified by retrograde labeling with tetramethylrhodamine dextran amine. AVT-Oregon green was internalized by 72% of these neurons. These results show that AVT can directly affect a very large and diverse medullary neuronal population, which may underlie the peptide's role in multiple neuroendocrinological processes, including autonomic and behavioral regulation. Selectivity of the AVT action may arise through interactions between AVT and steroids such as corticosterone.

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Rapid corticosterone-induced impairment of amplectic clasping occurs in the spinal cord of roughskin newts (taricha granulosa)

Cited by 25 publications

References 18 publications

Frank Beach Award Winner: Steroids as neuromodulators of brain circuits and behavior

Frank Beach Award Winner: Steroids as neuromodulators of brain circuits and behavior

Rapid Central Corticosteroid Effects: Evidence for Membrane Glucocorticoid Receptors in the Brain

Identification of roughskin newt medullary vasotocin target neurons with a fluorescent vasotocin conjugate

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