Rapid determination of intraoperative blood propofol concentration in operating theatre by dopant-enhanced neutral release and negative photoionization ion mobility spectrometry

Xiao, Yao; Wang, Xin; Li, Enyou; Chen, Hong; Wang, Chenyang; Zhang, Yuanzhi; Jiang, Dandan; Chen, Chuang; Li, Haiyang

doi:10.1016/j.aca.2019.11.011

Cited by 9 publications

(3 citation statements)

References 26 publications

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“…21 HPPI-TOFMS has successfully monitored the concentration of exhaled propofol during surgery and has shown good association with blood propofol concentration and bispectral index. [21][22][23] As shown by Hanna et al, 14 previous studies on breath tests have had substantial limitations and potential bias, such as small sample size, poor methodological quality, and lack of validation. In our case-control diagnostic study, we investigated whether a breath test combining HPPI-TOFMS and a support vector machine (SVM) algorithm was able to distinguish patients with lung cancer from healthy individuals.…”

Section: Introductionmentioning

confidence: 99%

“…High-pressure photon ionization time-of-flight mass spectrometry (HPPI-TOFMS) is a promising tool for breath testing, because it is highly sensitive, does not require pretreatment of exhaled breath, and holds great tolerance for humidity . HPPI-TOFMS has successfully monitored the concentration of exhaled propofol during surgery and has shown good association with blood propofol concentration and bispectral index …”

Section: Introductionmentioning

confidence: 99%

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Assessment of an Exhaled Breath Test Using High-Pressure Photon Ionization Time-of-Flight Mass Spectrometry to Detect Lung Cancer

Meng

Zhou

et al. 2021

JAMA Netw Open

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IMPORTANCE Exhaled breath is an attractive option for cancer detection. A sensitive and reliable breath test has the potential to greatly facilitate diagnoses and therapeutic monitoring of lung cancer.OBJECTIVE To investigate whether the breath test is able to detect lung cancer using the highly sensitive high-pressure photon ionization time-of-flight mass spectrometry (HPPI-TOFMS). DESIGN, SETTING, AND PARTICIPANTSThis diagnostic study was conducted with a prospectivespecimen collection, retrospective-blinded evaluation design. Exhaled breath samples were collected before surgery and detected by HPPI-TOFMS. The detection model was constructed by support vector machine (SVM) algorithm. Patients with pathologically confirmed lung cancer were recruited from Peking University People's Hospital, and healthy adults without pulmonary noncalcified nodules were recruited from Aerospace 731 Hospital. Data analysis was performed from August to October 2020. EXPOSURES Breath testing and SVM algorithm. MAIN OUTCOMES AND MEASURESThe detection performance of the breath test was measured by sensitivity, specificity, accuracy, and area under the receiver-operating characteristic curve (AUC). RESULTSExhaled breath samples were from 139 patients with lung cancer and 289 healthy adults, and all breath samples were collected and tested. Of all participants, 228 (53.27%) were women and the mean (SD) age was 57.0 (11.4) years. After clinical outcomes were ascertained, all participants were randomly assigned into the discovery data set (381 participants) and the blinded validation data set (47 participants). The discovery data set was further broken into a training set (286 participants) and a test set (95 participants) to construct and test the detection model. The detection model reached a mean (SD) of 92.97% (4.64%) for sensitivity, 96.68% (2.21%) for specificity, and 95.51%(1.93%) for accuracy in the test set after 500 iterations. In the blinded validation data set (47 participants), the model revealed a sensitivity of 100%, a specificity of 92.86%, an accuracy of 95.74%, and an AUC of 0.9586. CONCLUSIONS AND RELEVANCEThis diagnostic study's results suggest that a breath test with HPPI-TOFMS is feasible and accurate for lung cancer detection, which may be useful for future lung cancer screenings.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of an Exhaled Breath Test Using High-Pressure Photon Ionization Time-of-Flight Mass Spectrometry to Detect Lung Cancer

Meng

Zhou

et al. 2021

JAMA Netw Open

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“…However, PRIS has been reported when low doses of propofol have been administered. 13 Since the Coronavirus pandemic began, the risk of PRIS has increased. 14,15 Propofol also can be abused, and related cases of suicide, overdose death, and murder have been reported.…”

Section: Introductionmentioning

confidence: 99%

Dynamic headspace solid-phase extraction at room temperature: a theoretical model, method, and application for propofol analysis

Nakhodchi

Alizadeh

2023

Anal. Methods

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Rapid determination and continuous monitoring of propofol in microliter whole blood sample during anesthesia by paper spray ionization-mass spectrometry

Liu

Zhang

et al. 2020

Anal Bioanal Chem

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Rapid determination of intraoperative blood propofol concentration in operating theatre by dopant-enhanced neutral release and negative photoionization ion mobility spectrometry

Cited by 9 publications

References 26 publications

Assessment of an Exhaled Breath Test Using High-Pressure Photon Ionization Time-of-Flight Mass Spectrometry to Detect Lung Cancer

Assessment of an Exhaled Breath Test Using High-Pressure Photon Ionization Time-of-Flight Mass Spectrometry to Detect Lung Cancer

Dynamic headspace solid-phase extraction at room temperature: a theoretical model, method, and application for propofol analysis

Rapid determination and continuous monitoring of propofol in microliter whole blood sample during anesthesia by paper spray ionization-mass spectrometry

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