Rapid fabrication method of a microneedle mold with controllable needle height and width

Lin, Yi‐Ying; Lee, I‐Chi; Hsu, Wei-Chieh; Hsu, Ching-Hong; Chang, Kai-Ping; Gao, Shao-Syuan

doi:10.1007/s10544-016-0113-8

Cited by 28 publications

(22 citation statements)

References 31 publications

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“…Then, the upper one is lifted to make the polymer stretch, which forms microneedle structures that can be solidified by heat [ 55 ], electric field [ 56 ], magnetic field [ 57 ], or centrifugal force [ 58 ]. When a mold is used, the shape of microneedles can be solidified by crosslinking with heat or ultraviolet (UV) light [ 59 ]. Last but not least, three-dimensional (3D) printing is also another way to manufacture MNs.…”

Section: The Manufacture Of Microneedlesmentioning

confidence: 99%

“…Lin et al solidified resin by using 30–40 s exposure to UV light with different power outputs. Then, the solidified structures were replicated with polydimethylsiloxane (PDMS) to make a microneedle array mold, which can be filled with water-soluble or biodegradable materials ( Figure 6 B) [ 59 ]. Yu et al made the microneedles using two steps, casting and coating.…”

Section: The Manufacture Of Microneedlesmentioning

confidence: 99%

“…( D ) Scheme of producing a personalized microneedle by 3D printing. (Images were reproduced with permission from [ 55 , 59 , 62 , 63 ]).…”

Section: Figurementioning

confidence: 99%

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Advances of Microneedles in Biomedical Applications

Xuan

et al. 2021

Molecules

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A microneedle (MN) is a painless and minimally invasive drug delivery device initially developed in 1976. As microneedle technology evolves, microneedles with different shapes (cone and pyramid) and forms (solid, drug-coated, hollow, dissolvable and hydrogel-based microneedles) have been developed. The main objective of this review is the applications of microneedles in biomedical areas. Firstly, the classifications and manufacturing of microneedle are briefly introduced so that we can learn the advantages and fabrications of different MNs. Secondly, research of microneedles in biomedical therapy such as drug delivery systems, diagnoses of disease, as well as wound repair and cancer therapy are overviewed. Finally, the safety and the vision of the future of MNs are discussed.

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Section: The Manufacture Of Microneedlesmentioning

confidence: 99%

Section: The Manufacture Of Microneedlesmentioning

confidence: 99%

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Advances of Microneedles in Biomedical Applications

Xuan

et al. 2021

Molecules

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“…The agitation, however, makes the process unrepeatable, hard to control, and non-uniform across a wafer [35][36], lowering the possibility of mass production [37]. Furthermore, when Mukerjee and co-workers [11] alternated between agitation and non-agitation of the etchant to laterally impose a directional bias to sharpen the microneedle tip, both microneedle height and base were etched during the quiescent phase, leading to a detrimental, non-uniform microneedle shapes. Stoeber [10] also used non-agitated isotropic acid etchant to polish the surface, but microneedle base was etched during this step which can lead to geometric variation from the initial design.…”

Section: Fabrication Overviewmentioning

confidence: 99%

A repeatable and scalable fabrication method for sharp, hollow silicon microneedles

Kim

Theogarajan

Pennathur

2018

J. Micromech. Microeng.

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Abstract-Scalability and manufacturability are impeding the mass commercialization of microneedles in the medical field. Specifically, microneedle geometries need to be sharp, beveled, and completely controllable, difficult to achieve with microelectromechanical fabrication techniques. In this work, we performed a parametric study using silicon etch chemistries to optimize the fabrication of scalable and manufacturable beveled silicon hollow microneedles. We theoretically verified our parametric results with diffusion reaction equations and created a design guideline for a various set of miconeedles (80 -160 m needle base width, 100 -1000 m pitch, 40 -50 m inner bore diameter, and 150 -350 m height) to show the repeatability, scalability, and manufacturability of our process. As a result, hollow silicon microneedles with any dimensions can be fabricated with less than 2% non-uniformity across a wafer and 5% deviation between different processes. The key to achieving such high uniformity and consistency is a non-agitated HF-HNO 3 bath, silicon nitride masks, and surrounding silicon filler materials with well-defined dimensions. Our proposed method is non-labor intensive, well defined by theory, and straightforward for wafer scale mass production, opening doors to a plethora of potential medical and biosensing applications.

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“…Therefore, MNs have been used as a therapeutic means to overcome this structural barrier. Previous studies have reported a method wherein a drug is embedded on the MNs using various methods, including dipping, coating, and drawing lithography [ 16 , 17 , 18 , 19 , 20 ]. In addition, biocompatible and self-dissolving MNs such as microfluidic channels ensure that the drug is absorbed in the body.…”

Section: Introductionmentioning

confidence: 99%

Effective Dispensing Methods for Loading Drugs Only to the Tip of DNA Microneedles

et al. 2020

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Here, we propose a novel and simple method to efficiently capture the diffusion of fluorescein isothiocyanate (FITC)-dextran from a biocompatible substance and load the drug only to the tip of DNA microneedles. A dispensing and suction method was chosen to fabricate the designed microneedles with efficient amounts of FITC as the drug model. Importantly, the vacuum process, which could influence the capturing of FITC diffusion from the tip, was evaluated during the manufacturing process. In addition, the simulations were consistent with the experimental results and showed apparent diffusion. Moreover, dextrans of different molecular weights labeled with FITC were chosen to fabricate the tip of microneedles for demonstrating their applicability. Finally, a micro-jetting system with a micro-nozzle (diameter: 80 μm) was developed to achieve the accurate and rapid loading of small amounts of FITC using the anti-diffusion and micro-jetting methods. Our method not only uses a simple and fast manufacturing process, but also fabricates the tips of microneedles more efficiently with FITC compared with the existing methods. We believe that the proposed method is essential for the clinical applications of the microneedle drug delivery platform.

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Rapid fabrication method of a microneedle mold with controllable needle height and width

Cited by 28 publications

References 31 publications

Advances of Microneedles in Biomedical Applications

Advances of Microneedles in Biomedical Applications

A repeatable and scalable fabrication method for sharp, hollow silicon microneedles

Effective Dispensing Methods for Loading Drugs Only to the Tip of DNA Microneedles

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