Rapid Hydrolysis of Penicillin Antibiotics Mediated by Adsorbed Zinc on Goethite Surfaces

Abstract

The soil environment is an important sink for penicillin antibiotics released from animal manure and wastewater, but the mineral-catalyzed transformation of penicillins in soil has not been well studied. To simulate this environmental process, we systematically investigated the behavior of penicillin G and amoxicillin, the two most widely-used penicillin antibiotics, in the presence of goethite and metal ions. The results demonstrated that Zn ions significantly promoted the hydrolysis of penicillins in goethite suspensions, as evidenced by the degradation rate nearly 3 orders of magnitude higher than that of the non-Zn-containing control. The spectroscopic analysis indicated that the specific complexation between penicillins, adsorbed Zn, and goethite was responsible for the enhanced degradation. Metastable interactions, involving hydrogen bonds between carbonyl groups in the β-lactam ring and the double/triple hydroxyl groups on goethite surface, and coordination bonding between carboxyl groups and surface irons were proposed to stabilize the ternary reaction intermediates. Moreover, the surface zinc-hydroxide might act as powerful nucleophile to rapidly rupture the β-lactam ring in penicillins. This study is among the first to identify the synergic roles of Zn ion and goethite in facilitating penicillin degradation and provides insights into β-lactam antibiotics to assess their environmental risk in soil.

Dynamic interactions at the mineral–organic matter interface

“…Furthermore, mineral surfaces can transfer protons to a sorbate as well as offer empty electron orbitals for the reception of bonding electron pairs (Broensted-and Lewis-acid/base functionalities 120 ). Lastly, minerals entirely made of transition metals (such as Fe and Mn oxides) or acting as solid supports for adsorbed transition metals at their surfaces and in interlayers (phyllosilicates) can contribute transition metal specific catalytic functionality 121,122 .…”

Interfacial Charge Transfer between Silver Phosphate and W2N3 Induced by Nitrogen Vacancies Enhances Removal of β‐Lactam Antibiotics

“…[6][7][8][9] The β-lactam antibiotics are the most frequently used antibiotics, accounting for more than 50% of the total worldwide antibiotic consumption. [10] In addition, penicillin G (PNL) and amoxicillin (AMX) are among the most commonly used β-lactam antibiotics, which are also the most vulnerable to leakage into the environment. [11] For example, Lu et al investigated 15 target antibiotics in the water of Jiaozhou Bay in China, and the results indicated that the AMX contamination accounted for 44% of the total concentration of antibiotics, which was the highest proportion among the 14 detected antibiotics.…”

“…[16,17] As a classical visible light-responsive semiconductor photocatalyst, silver phosphate (Ag 3 PO 4 ) has attracted much attention due to its high photocatalytic oxidation ability. [10,18] However, the defects of poor photostability and unsatisfactory electron-hole separation yield limit the wide application of Ag 3 PO 4 . Therefore, various attempts have been made to overcome the abovementioned drawbacks, such as morphology optimization, [19] ion doping, [20] facet engineering, [21] and heterojunction construction.…”

“…[ 6–9 ] The β‐lactam antibiotics are the most frequently used antibiotics, accounting for more than 50% of the total worldwide antibiotic consumption. [ 10 ] In addition, penicillin G (PNL) and amoxicillin (AMX) are among the most commonly used β‐lactam antibiotics, which are also the most vulnerable to leakage into the environment. [ 11 ] For example, Lu et al.…”

Enzyme-catalyzed biodegradation of penicillin fermentation residues by β-lactamase OtLac from Ochrobactrum tritici

“…For example, the use of photoelectric-Fenton oxidation (PEF) technology for the treatment of ampicillin [ 13 ]; the use of ionizing radiation to degrade penicillin [ 14 ]; and the use of UV/TiO 2 photocatalytic degradation of amoxicillin can achieve amoxicillin degradation. Penicillin can be degraded by nano Fe/Ni (B-Fe/Ni) supported by functional bentonite [ 15 ], Zinc-Loaded materials on a goethite surface [ 16 ], CoFe 2 O 4 @CuS magnetic nanocomposite and so on [ 17 ]. However, these methods are costly, the processing conditions are harsh, and it is difficult to scale up.…”