Rapid Hypertensinogenic Effect of Lead: Studies in the Spontaneously Hypertensive Rat

Nakhoul, Farid; Kayne, L. H.; Brautbar, Nachman; Hu, Ming-Shu; McDonough, Alicia A.; Eggena, Peter; Golub, Michael S.; Berger, Morris E.; Chang, Chwen‐Tzuei; Jamgotchian, Nora; Lee, David B. N.

doi:10.1177/074823379200800108

Cited by 3 publications

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 15 studies in which the lead dose in drinking water or food exceeded 1 p.p.m., the association between blood pressure and exposure was found to be positive in seven [ 133,137,139,140,143,144,152], inconsistent in three [138,141,150], absent in four [142,145,151,153], and negative in one 11461. Of the six studies at lower exposure levels ( 5 1 p.p.m.)…”

Section: Relationship Between Blood Pressure and Lead Exposure In Thementioning

confidence: 91%

Public Health Implications of Environmental Exposure to Cadmium and Lead: An Overview of Epidemiological Studies in Belgium

Staessen

Buchet²,

Ginucchio

et al. 1996

European Journal of Cardiovascular Prevention & Rehabilitat

View full text Add to dashboard Cite

on behalf of the Working Groupst Review in DepthThe CadmiBel Study was a cross-sectional population study that investigated the health effects of environmental exposure to cadmium and lead. The 2327 participants constituted a random sample of the population of four Belgian districts, chosen in order to provide a wide range of environmental exposure to cadmium. After adjustment for confounding factors, such as smoking and occupational exposure, the urinary cadmium excretion, a measure of lifetime exposure, was nearly 30% higher in the polluted areas. The CadmiBel Study produced evidence inconsistent with the hypothesis that environmental exposure to cadmium and lead would lead to an increase in blood pressure and to a higher prevalence of hypertension and other cardiovascular diseases. On the other hand, the serum alkaline phosphatase activity and the urinary excretion of calcium were significantly and positively correlated with urinary cadmium in both sexes. These findings suggested that the homeostasis of calcium was gradually affected as cadmium accumulated in the body. Furthermore, several markers of renal tubular dysfunction (urinary excretion of retinol-binding-protein, N-acetyl-,f3-glucosaminidase, ,f3z-microglobulin and amino acids) were significantly and positively associated with urinary cadmium. Across 10 small areas of which six were polluted with cadmium, an inverse association existed between the creatinine clearance and several indexes of environmental exposure to cadmium (cadmium concentration in the soil, cadmium content of locally grown vegetables, the inhabitants' 24 h urinary cadmium excretion). In the CadmiBel Study, the creatinine clearance was also inversely correlated with the concentrations of lead and zinc protoporphyrin in the blood. Thus, environmental exposure to cadmium and lead was associated with alterations in renal function. The significance in terms of morbidity and mortality of the functional disturbances observed in the CadmiBel Study, and the possible strategies to prevent the transfer of cadmium from the environment to man are under investigation in the prospective PheeCad Study in which half of the CadmiBel participants have been enrolled (participation rate 80%).

show abstract

Section: Relationship Between Blood Pressure and Lead Exposure In Thementioning

confidence: 91%

Public Health Implications of Environmental Exposure to Cadmium and Lead: An Overview of Epidemiological Studies in Belgium

Staessen

Buchet²,

Ginucchio

et al. 1996

European Journal of Cardiovascular Prevention & Rehabilitat

View full text Add to dashboard Cite

show abstract

Effects of short-term and subchronic lead poisoning on nitric oxide methabolites and vascular responsiveness in rat

Heydari¹,

Ali²,

Khoshbaten³

et al. 2006

Toxicology Letters

View full text Add to dashboard Cite

Lead, Blood Pressure, and Cardiovascular Disease in Men

Schwartz¹

1995

Archives of Environmental Health: An International Journal

150

View full text Add to dashboard Cite

Animal studies have demonstrated that relatively low doses of lead can produce modest elevations in blood pressure. During the past 10 y, many epidemiologic studies have examined the relationship between low-level lead exposure and blood pressure in humans. These studies were reviewed in a consensus conference, which concluded that the evidence supported the existence of a causal association; however, no formal meta-analysis has been conducted. Epidemiologic studies of blood lead and systolic blood pressure in males were analyzed in the present meta-analysis. A highly significant and moderately consistent association was found, i.e., decrease of blood lead from 10 mg/dl to 5 mg/dl associated with a decrease of 1.25 mm Hg (95% CI = 0.87-1.63 mm Hg). The association was robust to deletion of the most significant study or the addition of eight additional studies showing no effect. Given the strong animal data, which also implicate a mechanism (disturbance of calcium messenger system regulation of blood pressure) present in humans, the association should be considered causal.

show abstract

Rapid Hypertensinogenic Effect of Lead: Studies in the Spontaneously Hypertensive Rat

Cited by 3 publications

References 25 publications

Public Health Implications of Environmental Exposure to Cadmium and Lead: An Overview of Epidemiological Studies in Belgium

Public Health Implications of Environmental Exposure to Cadmium and Lead: An Overview of Epidemiological Studies in Belgium

Effects of short-term and subchronic lead poisoning on nitric oxide methabolites and vascular responsiveness in rat

Lead, Blood Pressure, and Cardiovascular Disease in Men

Contact Info

Product

Resources

About