Rapid Increase of Phenylethanolamine
            <i>N</i>
            -Methyltransferase by Environmental Stress in an Inbred Mouse Strain

Ciaranello, Roland D.; Dornbusch, Jeffrey N.; Barchas, Jack D.

doi:10.1126/science.175.4023.789

Cited by 14 publications

(5 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A single immobilization stress causes a small but significant increase (50%) in adrenal PNMT activity, which is not elevated further even after repeated immobilizations . A similar increase in adrenal PNMT activity is elicited by exposure of animals to cold stress (Ciaranello et al ., 1971 ;Kvetnansky et al ., 1971a), but the changes in PNMT activity are generally smaller than those of the other enzymes involved in catecholamine biosynthesis (reviewed by Kvetnansky and Sabban, 1993) . However, the changes in PNMT gene expression during stress have not been studied extensively .…”

mentioning

confidence: 55%

Increase in Rat Adrenal Phenylethanolamine N‐Methyltransferase mRNA Level Caused by Immobilization Stress Depends on Intact Pituitary ‐ Adrenocortical Axis

Viskupic

Květňanský

Sabban

et al. 1994

Journal of Neurochemistry

View full text Add to dashboard Cite

The effects of a single and of repeated immobilization stress on the expression of the final enzyme involved in epinephrine biosynthesis, phenylethanolamine N‐methyltransferase (PNMT), are described. A single immobilization (whether lasting 5 or 120 min) caused a severalfold increase of the adrenal PNMT mRNA level as measured 2 h after the beginning of the procedure. This elevation was of a transient nature, peaked 3–6 h after the 2‐h immobilization, and returned to control values by 12 h after the stress. When the animals were immobilized for 2 h/day for seven consecutive days, an increase in content of PNMT mRNA of a similar magnitude was observed, which persisted for at least 2 days after the seventh immobilization. The immobilization‐induced increase was completely abolished in hypophysectomized animals, whereas adrenal denervation failed to prevent it. These data suggest that the immobilization‐induced increase in adrenal PNMT mRNA level depends primarily on pituitary‐adrenocortical regulation.

show abstract

mentioning

confidence: 55%

Increase in Rat Adrenal Phenylethanolamine N‐Methyltransferase mRNA Level Caused by Immobilization Stress Depends on Intact Pituitary ‐ Adrenocortical Axis

Viskupic

Květňanský

Sabban

et al. 1994

Journal of Neurochemistry

View full text Add to dashboard Cite

show abstract

“…All studies were performed in male mice, age [11][12][13][14] weeks. Balb/cJ mice were obtained from the Jackson Laboratories, Bar Harbor, Me.…”

Section: Aind Materialsmentioning

confidence: 99%

Association Between Fighting Behavior and Catecholamine Biosynthetic Enzyme Activity in Two Inbred Mouse Sublines

Ciaranello

Lipsky

Axelrod

1974

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Levels of three adrenal catecholamine synthesizing enzymes and isolation-induced fighting behavior were studied in two related sublines of the Balb/c inbred mouse strain. Enzyme levels were twice as high in the adrenals of Balb/cJ mice as in those of the Balb/cN mice; heterozygous progeny were intermediate between their parents in the levels of the three enzymes.These sublines also showed marked differences in their fighting behavior after a 2-week isolation period. Balb/cJ mice fought immediately after presentation of an intruder mouse, while Balb/cN mice did not fight at any time during the test. Heterozygous progeny behaved more like the Balb/cN (non-fighters). Analysis of F2 mice suggested that the differences in fighting behavior were determined by a single gene, with fighting being recessive.

show abstract

“…The positive relationship observed between the increased stressing conditions and the increasing frequency of MN might support the hypothesis of association of continuous altered environmental factors (temperature oscillation, noise and photoperiod) and genomic damaging. Several authors have suggested stress as an induce genoto‐xic damage, both at the chromosomal and the molecular levels (Adachi, Kawamura, & Takemoto, 1993; Ciaranello, Dornbusch, & Barchas, 1972; Fischman, Pero, & Kelly, 1996; Glaser, Thorn, Tarr, Kiecolt‐Glaser, & D'Ambrosio, 1985; Kiecolt‐Glaser, Stephens, Lipetz, Speicher, & Glaser, 1985) and the present research seems to corroborate such previous results by new environmental‐based associations with a progressive chromosome damage on peripheral blood cells of Rattus norvegicus .…”

Section: Discussionmentioning

confidence: 99%

On the stress by photoperiod, temperature and noise as possible causes of genomic damaging in an animal model

Adam¹,

Torres²,

Franci³

et al. 2010

Stress and Health

View full text Add to dashboard Cite

Stress is a defense mechanism of an organism and is directly related to homeostasis, which is the equilibrium state of the multitude of organism systems, both among each other and with the environment. Given that stress is a major cause of cellular instability, it is directly related to its loss homeostasis. The present study assessed the changes caused by stress on the genetic material of Rattus norvegicus using micronuclei analysis. A total of 10 males were studied by being submitted to continuous stress from photoperiod, temperature and noise for 26 days. Peripheral blood samples were obtained immediately before submitting the animals to stress, as well as on the fifteenth and twenty‐sixth days afterwards. Blood smears were stained with Giemsa and the slides were analyzed using light microscopy. Approximately 3,000 polychromatic erythrocytes from each animal were observed and classified as either normal or micronucleated. The analysis indicated a frequency of 0.0012014 for the control sample, whereas samples on days 15 and 26 had frequencies of 0.0035458 and 0.0496850, respectively. A statistical analysis revealed statistically significant differences among the studied cell samples (ANOVA p < 0.00001, significance of 5%). Therefore, the presence of micronuclei in the studied samples is consistent with a cause/effect relationship. Copyright © 2010 John Wiley & Sons, Ltd.

show abstract

Rapid Increase of Phenylethanolamine N -Methyltransferase by Environmental Stress in an Inbred Mouse Strain

Cited by 14 publications

References 6 publications

Increase in Rat Adrenal Phenylethanolamine N‐Methyltransferase mRNA Level Caused by Immobilization Stress Depends on Intact Pituitary ‐ Adrenocortical Axis

Increase in Rat Adrenal Phenylethanolamine N‐Methyltransferase mRNA Level Caused by Immobilization Stress Depends on Intact Pituitary ‐ Adrenocortical Axis

Association Between Fighting Behavior and Catecholamine Biosynthetic Enzyme Activity in Two Inbred Mouse Sublines

On the stress by photoperiod, temperature and noise as possible causes of genomic damaging in an animal model

Contact Info

Product

Resources

About