Rapid label-free determination of ketamine in whole blood using secondary ion mass spectrometry

Liao, Hua‐Fang; Chen, Jung-Hsuan; Shyue, Jing‐Jong; Shun, Chia‐Tung; Chen, Huei‐Wen; Liao, Su-Wei; Hong, Chih-Kang; Chen, Pai‐Shan

doi:10.1016/j.talanta.2015.04.074

Cited by 6 publications

(3 citation statements)

References 50 publications

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“…Therefore, according to the established regularities, they must be ionized by the SI with high efficiency. 11–13 These suggestions were also proved by our previous published papers. High selectivity of the SI method and indicator lines in the SI mass spectra as well as the additivity of mass spectra allowed us to analyze omnoponum and extract of narcotic users by SI/MS without their preliminary separation.…”

Section: Resultssupporting

confidence: 64%

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Direct detection of morphine in human urine by surface-ionization mass spectrometry

Usmanov

Akhunov

Khasanov

et al. 2019

Eur J Mass Spectrom (Chichester)

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Detection and analysis of drugs-of-abuse in biological fluids are the essential tasks for the law enforcement, forensic toxicology, doping research and social health. In this work, we developed a surface-ionization mass spectrometry method for direct detection of trace amount of morphine spiked in blank urine. The mass-spectrometric analysis of spiked samples was carried out without preliminary extraction and chromatographic separation. It was found out that the major fragment ions at m/z 144, 146 could be served as indicator lines of morphine spiked in blank urine. Limit of detection of morphine spiked in blank urine was 100 pg (50 ng/ml), and a linear range of calibration curve was more than two orders of magnitude. The spiked samples were also analyzed by gas chromatography–mass spectrometry without preliminary extraction and derivatization procedures. No morphine was found in the spiked samples. The experimental data show that the high selectivity of the surface ionization can be allowed to direct analysis of morphine spiked in blank urine without its preliminary extraction and chromatographic separation.

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Section: Resultssupporting

confidence: 64%

“…At present time, vacuum ionization methods are rare for detection of narcotics in biofluids. 11–13 One of the perspective methods in vacuum for sensitive and direct detection of trace amounts of narcotics in bio-samples is surface ionization (SI). The SI method is simple, sensitive and selective.…”

Section: Introductionmentioning

confidence: 99%

Direct detection of morphine in human urine by surface-ionization mass spectrometry

Usmanov

Akhunov

Khasanov

et al. 2019

Eur J Mass Spectrom (Chichester)

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show abstract

“…Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is a surface-sensitive analytical method. It is a powerful technique for analysing and directly mapping chemical components on the surfaces of solid samples [9][10][11][12][13][14][15]. In combination with a ToF analyser, ToF-SIMS provides several advantages compared with other mass spectrometric and surface-sensitive techniques.…”

Section: Introductionmentioning

confidence: 99%

Time-of-flight secondary ion mass spectrometry analysis of chitosan-treated viscose fibres

Finšgar

Ristić

Fardim

et al. 2018

Analytical Biochemistry

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Time-of-flight secondary ion mass spectrometry (ToF-SIMS) was employed to analyse cellulose viscose fibres treated with different chitosan-based solutions. The analysis reports several new features in the TOF-SIMS spectra for systems with various forms of chitosan-treated surfaces. The characteristic positive ion TOF-SIMS signals for chitosan are reported at m/z 147.90, 207.07, and 221.09, and characteristic signals for trimethyl chitosan are present at m/z 58.03 and 102.09. Furthermore, new fragments were suggested to characterise acetylated chitosan molecules. The relative surface concentrations of different species were obtained based on the specific signal ratios (originating from a specific fragment and cellulose). SIMS imaging was then performed in order to investigate the surface distribution of chitosan, trimethyl chitosan, and Na-containing nanoparticles. In order to perform TOF-SIMS imaging, the above-mentioned characteristic signals were employed and m/z 22.99 was used for Na nanoparticles.

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Selective detection of ketamine in human urine samples by electrochemiluminescence sensor based on conductive molecular imprinted polypyrrole: A hydrogen peroxide‐free electrochemiluminescence assay

Ahmadi,

Alizadeh

2024

J Chinese Chemical Soc

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A new sensor was fabricated for the determination of ketamine (Ket) in urine samples based on enhanced electrochemiluminescence (EECL) behavior of luminol on a carbon paste electrode (CPE) modified with the conductive molecularly imprinted polymer (CMIP) film. The FESEM technique was applied to demonstrate the rod shape morphology of CMIP. Unlike the common luminol system, EECL signal of luminol no need to addition of hydrogen peroxide and it might find application in efforts to avoid instability of hydrogen peroxide or its interference with the analytes of interest. The EECL emission has been optimized by an investigation of the applied potentials, electrochemical polymerization conditions, template and modifier concentrations, and the pH solution. Under the optimum conditions, the EECL signal depended linearly on the Ket concentration within a range from 0.1 to 1.25 μM with a limit of detection (LOD) of 0.08 μM. The sensor exhibited very good recovery percentages ranging from 92% to 101% in urine samples, while precisions were ≤3%. These results suggested that the proposed sensor would be applicable for analysis Ket in complex matrixes without interfering of other drugs (anesthetics) and thus has the potential to be used in clinical application.

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Rapid label-free determination of ketamine in whole blood using secondary ion mass spectrometry

Cited by 6 publications

References 50 publications

Direct detection of morphine in human urine by surface-ionization mass spectrometry

Direct detection of morphine in human urine by surface-ionization mass spectrometry

Time-of-flight secondary ion mass spectrometry analysis of chitosan-treated viscose fibres

Selective detection of ketamine in human urine samples by electrochemiluminescence sensor based on conductive molecular imprinted polypyrrole: A hydrogen peroxide‐free electrochemiluminescence assay

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