Rapid synthesis of 2‐deoxy‐D (1‐<sup>14</sup>C) glucose suitable for labelling with <sup>11</sup>C

Mestelan, G.; Aubert, F.; Beaucourt, J. P.; Comar, D.; Pichat, L.

doi:10.1002/jlcr.2580160502

Cited by 8 publications

(2 citation statements)

References 16 publications

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“…Unlike the triflate lb, the iodide la is stable ; it can be prepared on a large scale and can be stored almost indefenitily (7). In addition, the puri-f ication procedure for the 11C-2DG radiopharmaceutical has been modified to include only ion-exchange chromatography.…”

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confidence: 99%

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Routine production of 2‐deoxy‐D‐[1‐¹¹C]glucose : An alternative

Haver¹,

Rabi²,

Vandewalle³

et al. 1985

Labelled Comp Radiopharmac

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The routine production of 2-deoxy-D-[l-llC] glucose (11C-2DG) 11 from [ C] hydrogen cyanide and 2 , 3 : 4 , 5-di-0-isopropylidene-1-iodo-D-arabinitol is described. The nitrile intermediate is purifiedby high-performance liquid chromatography (HPLC) before reduction/ hydrolysis with Raney alloy in formic acid. The radiopharmaceutical is isolated by i o n exchange and is obtained in a radioche-mica1 yield of 2 0 % with a synthesis time of 50-55 min. A typical run affords 2 5 -3 0 mCi of "C-ZDG with a specific activity of 90-100 mCi/mg.

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confidence: 99%

“…Di-0-isopropylidene-l-iodo-D-arabinitol(9) was prepared from D-arabinitol (Fluka AG) according to Mestelan et al(7). It was purified on a 10-pm silica HPLC column (50 x 0.68 cm) with ethyl acetate-n.hexane 6 : 4 (v/v) as eluent and stored as a 0.05 M solution in dry N,N-dimethylformamide.…”

mentioning

confidence: 99%

Routine production of 2‐deoxy‐D‐[1‐¹¹C]glucose : An alternative

Haver¹,

Rabi²,

Vandewalle³

et al. 1985

Labelled Comp Radiopharmac

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3‐[¹¹C]‐methyl‐D‐glucose, a potential agent for regional cerebral glucose utilization studies: Synthesis, chromatography and tissue distribution in mice

Kloster

Müller‐Platz

Laufer

1981

Labelled Comp Radiopharmac

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Quality control procedures in the preparation of 2‐deoxy‐D‐[1‐¹¹C] glucose radiopharmaceutical

Vora

Boothe

Finn

et al. 1983

Labelled Comp Radiopharmac

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Preparation and quality control of 2‐deoxy‐D‐[1‐11C] glucose (11C‐2DG, 1) have been accomplished by a combination of cation‐exchange and high performance liquid chromatography (HPLC) to give the radiopharmaceutical in greater than 99% radiochemical purity and an overall 25‐35% radiochemical yield in 45‐50 min. Quality control procedures utilizing GC and HPLC have been developed to determine not only chemical and radiochemical purity of the final product, but also to examine the reactants used and the products formed during the preparation of 1.

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Rapid synthesis of 2‐deoxy‐D (1‐¹⁴C) glucose suitable for labelling with ¹¹C

Abstract: D-arabitol ( I ) treated with acetone Gave 2, 3-4,5 and I , 2-4,5 di-0-isopropylidene-D-arabitol ( I I ) as shorn by 1 3 C NMR. This mixture was

Cited by 8 publications

References 16 publications

Routine production of 2‐deoxy‐D‐[1‐¹¹C]glucose : An alternative

Routine production of 2‐deoxy‐D‐[1‐¹¹C]glucose : An alternative

3‐[¹¹C]‐methyl‐D‐glucose, a potential agent for regional cerebral glucose utilization studies: Synthesis, chromatography and tissue distribution in mice

Quality control procedures in the preparation of 2‐deoxy‐D‐[1‐¹¹C] glucose radiopharmaceutical

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Rapid synthesis of 2‐deoxy‐D (1‐14C) glucose suitable for labelling with 11C

Abstract: D-arabitol ( I ) treated with acetone Gave 2, 3-4,5 and I , 2-4,5 di-0-isopropylidene-D-arabitol ( I I ) as shorn by 1 3 C NMR. This mixture was

Cited by 8 publications

References 16 publications

Routine production of 2‐deoxy‐D‐[1‐11C]glucose : An alternative

Routine production of 2‐deoxy‐D‐[1‐11C]glucose : An alternative

3‐[11C]‐methyl‐D‐glucose, a potential agent for regional cerebral glucose utilization studies: Synthesis, chromatography and tissue distribution in mice

Quality control procedures in the preparation of 2‐deoxy‐D‐[1‐11C] glucose radiopharmaceutical

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Rapid synthesis of 2‐deoxy‐D (1‐¹⁴C) glucose suitable for labelling with ¹¹C

Routine production of 2‐deoxy‐D‐[1‐¹¹C]glucose : An alternative

Routine production of 2‐deoxy‐D‐[1‐¹¹C]glucose : An alternative

3‐[¹¹C]‐methyl‐D‐glucose, a potential agent for regional cerebral glucose utilization studies: Synthesis, chromatography and tissue distribution in mice

Quality control procedures in the preparation of 2‐deoxy‐D‐[1‐¹¹C] glucose radiopharmaceutical