Rapidly decreasing prevalence of Helicobacter pylori among Japanese children and adolescents

Miyamoto, Ryosuke; Okuda, Masumi; Lin, Yingsong; Murotani, Kenta; Okumura, Akihisa; Kikuchi, Shogo

doi:10.1016/j.jiac.2019.02.016

Cited by 26 publications

(18 citation statements)

References 23 publications

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“…However, we should be cautious in discussing causative associations between developmental disorders and H. pylori infection. In Japan, the incidence of H. pylori infection declines with each generation ( 22 ), and this is true even among the young generation ( 12 ). On the other hand, developmental disorders have been increasing annually in Japan ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

High Prevalence of Helicobacter pylori Infection in Special Needs Schools in Japan

2021

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Background: Developmental disorders and high Helicobacter pylori (H. pylori) infection rates have been reported. This study aimed to examine the prevalence of H. pylori in a special needs school where all students had developmental disorders in Japan.Methods: In 2017, third-grade junior high school and second- and third-grade high school students attending a special needs school with developmental disorders were enrolled. Participants of Saga Prefecture's H. pylori test and treat project, which comprised third-grade junior high school students not from special needs school, were assigned to the control group.Results: In the control group, H. pylori positive results were 3.18% (228/7,164) students. Similarly, in developmental disorder group, H. pylori positive results were 6.80% (13/191) students. For the developmental disorder and control groups, this present examination sensitivity was 7.03% (13/185), specificity was 96.76% (6,815/7,043), positive predictive value was 5.39% (13/241), negative predictive value was 97.54% (6,815/6,987), Likelihood ratio of a positive result 2.17 and Odds ratio was 2.26 (95% confidence interval: 1.27–4.03, p = 0.005).Conclusion: The prevalence of H. pylori infection was significantly higher in adolescents with developmental disorders than in typically developing adolescents.

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Section: Discussionmentioning

confidence: 99%

High Prevalence of Helicobacter pylori Infection in Special Needs Schools in Japan

2021

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“…In developing countries, HP infection is usually acquired during childhood or early adulthood. However, in developed countries, a decreasing prevalence of HP infection among children and adolescents has been noted over the last few decades [20].…”

Section: Discussionmentioning

confidence: 99%

Upper socioeconomic status is associated with lower Helicobacter pylori infection rate among patients undergoing gastroscopy

Attila

Zeybel

Yiğit

et al. 2020

J Infect Dev Ctries

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Introduction: Socioeconomic factors play an important role in the prevalence of Helicobacter pylori (HP) infection. The aim of this study is to investigate HP prevalence among symptomatic patients in the upper socioeconomic segment of the population undergoing gastroscopy in an endemic urban region. Methodology: Over a 12-month period, data were collected from the first consecutive 1000 patients (500 from university hospital, 500 from community hospital) who had gastroscopy and HP evaluation. Results: Overall, 211/1000 patients (21.1 %) were found to have HP in gastric biopsies. The specificity, sensitivity, positive predictive value, negative predictive value and diagnostic accuracy of rapid urease test were 87.5%, 99.7%, 99%, 96.5%, and 96.9% respectively. Atrophic gastritis, gastric and duodenal ulcers were significantly more common in HP positive patients. Age based distribution of HP prevalence: > 6 decades (15.5%), 3rd-5th decades (26.1%), < 3rd decades (10.4%). Conclusion: In an HP endemic country, the prevalence of HP infection among symptomatic patients belonging to the upper socioeconomic segment of the population appears to be markedly lower. The lowest prevalence in young patients is expected to result in future decrease in HP prevalence.

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“…Studies published in the past year continue to demonstrate a decrease in prevalence of H pylori infection in children. A comprehensive review of data on Japanese children and adolescents between 1997 and 2017 showed that the prevalence of H pylori infection was approximately 10% in individuals born in 1985 but decreased to 3% in individuals born in 2011 1 . This declining prevalence was explained by the steady improvements in sanitation and living conditions from the 1950s and onwards, and it was speculated that the decreasing birth rate might have led to fewer children per family, thus decreasing the risk of intra‐familial infection 1 .…”

Section: Epidemiology Of Infectionmentioning

confidence: 99%

“…A comprehensive review of data on Japanese children and adolescents between 1997 and 2017 showed that the prevalence of H pylori infection was approximately 10% in individuals born in 1985 but decreased to 3% in individuals born in 2011 1 . This declining prevalence was explained by the steady improvements in sanitation and living conditions from the 1950s and onwards, and it was speculated that the decreasing birth rate might have led to fewer children per family, thus decreasing the risk of intra‐familial infection 1 . In a study from Korea, the seroprevalence of H pylori infection decreased from 50%‐70% in children aged 5‐7 years in 1988‐1989 to 15% in children aged 5‐14 years in 2014‐2015 2 .…”

Section: Epidemiology Of Infectionmentioning

confidence: 99%

Review: Helicobacter pylori infection in children

2020

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Helicobacter pylori infection in children and adolescents differs in comparison to adults with respect to epidemiology, host responses, and disease manifestations. Furthermore, treatment options are limited in this population and antibiotic resistance rates continue to increase. Therefore, ongoing research is vital to understand disease pathogenesis and provide optimal management of children with infection. This review summarizes relevant publications from April 2019 to March 2020. Similar to adults, recent studies show a decreasing prevalence of infection in the pediatric population. Studies of pathogenesis investigated serum immune responses and the potential inverse association of infection and allergy. Several studies investigated the effect of H pylori and related inflammation on the gut microbiome. The recommendation of endoscopy‐based testing to identify the cause of symptoms and not just H pylori, reserving noninvasive UBT or stool antigen tests for post‐eradication follow‐up, was supported by the current literature.

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Rapidly decreasing prevalence of Helicobacter pylori among Japanese children and adolescents

Cited by 26 publications

References 23 publications

High Prevalence of Helicobacter pylori Infection in Special Needs Schools in Japan

High Prevalence of Helicobacter pylori Infection in Special Needs Schools in Japan

Upper socioeconomic status is associated with lower Helicobacter pylori infection rate among patients undergoing gastroscopy

Review: Helicobacter pylori infection in children

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