2021
DOI: 10.1002/jssc.202100174
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Rapidly identifying bioactive compounds from Zhisou oral liquid by immobilized receptor‐based high‐performance affinity chromatography

Abstract: The identification of bioactive compounds in complex matrices remains a major challenge due to the lack of highly efficient and specific methods. This work developed an approach based on high‐performance affinity chromatography to identify the potential antitussive compounds from Zhisou oral liquid . The main methods include the synthesis of immobilized beta2‐adrenoceptor by a one‐step method, the screening and identification of the potential bioactive compounds by the receptor column coupled with mass spectro… Show more

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Cited by 8 publications
(2 citation statements)
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“…The HPAC column can offer not only the bio-selectivity of drug-protein target interactions, but also provide the stability, speed, and efficiency of the HPLC column. The pioneering works by Moaddel [11,13], Wainer [12], and Zhao [14][15][16][17][18][19][20][21] have established various HPAC methods with immobilized receptors and applied them in screening bioactive compounds from herbal medicines or DNA-encoded chemical libraries derived from natural products. Their results demonstrated that HPAC is an effective and reliable technique to discover lead compounds from natural products.…”
Section: Introductionmentioning
confidence: 99%
“…The HPAC column can offer not only the bio-selectivity of drug-protein target interactions, but also provide the stability, speed, and efficiency of the HPLC column. The pioneering works by Moaddel [11,13], Wainer [12], and Zhao [14][15][16][17][18][19][20][21] have established various HPAC methods with immobilized receptors and applied them in screening bioactive compounds from herbal medicines or DNA-encoded chemical libraries derived from natural products. Their results demonstrated that HPAC is an effective and reliable technique to discover lead compounds from natural products.…”
Section: Introductionmentioning
confidence: 99%
“…Herbal prescriptions have been applied to treat diseases for thousands of years in China, and their effectiveness has been proven by long-term clinical practice [1,2]. The discovery of active ingredients is an important way to elucidate the effectiveness of herbal prescriptions [3][4][5][6]. The traditional method to discover active ingredients is to purify compounds and then detect their bioactivity one by one [7,8].…”
Section: Introductionmentioning
confidence: 99%