Rare malignant glomus tumor of the stomach with liver metastases

Abstract

We report a case of a 72-year-old male admitted in our Unit with anemia and a 10 cm liver neoplasm. Computed tomography scan showed 2 lesions respectively in the II, III and, VIII segment of the liver. Surgical resection of the larger liver mass was performed and the tumor appeared as a solid-cystic mass and a diagnosis of malignant mesenchymal tumor not otherwise specified, was made. One month later a Computed tomography scan detected a dishomogeneous gastric mass, 6 cm in diameter, in the greater curvature, confirmed by esophagogastroduodenoscopy. The pathological diagnosis from endoscopic biopsy revealed a mesenchymal tumor requiring surgical removal for accurate diagnosis. The patient underwent relaparotomy and gastric resection and the pathological findings gave a diagnosis of a rare malignant glomic tumor of the stomach confirmed by the revision of previously performed hepatic resection classified as secondary lesion.

<p>Lesser Sac Glomangiosarcoma With Simultaneous Liver And Lymph Nodes Metastases Mimicking Small Bowel Gastrointestinal Stromal Tumor; Immunohistochemistry And Empirical Chemotherapy</p>

“…In the gastrointestinal tract, the stomach is the prevalent place for glomus tumors; however, there are only seven cases of malignant glomus tumors with metastasis in the stomach reported in the literature (Table 1). 1,4–9 The first case was reported in 2001 by Folpe et al in which the patient was a sixty-nine-year-old man with a 9.5-cm mass and liver metastasis 4. In 2002, Miettinen et al reported another patient who was also 69 years old with a 6.5-cm mass and liver metastasis 5.…”

“…The next published case was introduced in 2018 by Bodolan et al In this case, the patient was an eighty-year-old woman with a mass sized 7.1 cm and liver metastasis 1. And the last published case was a seventy-two-year-old male with a mass sized 6 cm that was introduced by Toti et al’s in 2019 9. Among the aforementioned patients, only the two last cases were alive currently, and Bray et al’s patient had the most survival rate which was 72 months 7.…”

Gastric Glomus Tumor: A Clinicopathologic and Immunohistochemical Study of 21 Cases

“…GGTs are deep soft tissue tumors, and the maximum tumor diameter in more than half of patients is greater than 2 cm [4,15,16]. In addition, a total of 11 patients with malignant GGTs have been reported in the literature with tumor sizes ranging from 3 to 14 cm, and 8 of the tumors were larger than 5 cm [14,4,17,7,18,19,20,21,22,23]. Therefore, a size of 5 cm might be a more appropriate indicator of risk for GGTs [4].…”

Gastric glomus tumor

“…Ancak mide glomus tümörleri için belirlenmiş herhangi bir kriter mevcut değildir. Literatürde mide glomus olguları genellikle benign gidişli olarak bildirilmekle birlikte, malign ya da metastatik gastrik glomus tümörü şeklinde az sayıda olgu da mevcuttur [14,15]. Bu olgulardan birinde tümör boyutu 6,5 cm ve mitoz 1-3/50 BBA izlenmiştir [9].…”