Ras-Transformed Cells Express Both CD44 and RHAMM Hyaluronan Receptors: Only RHAMM Is Essential for Hyaluronan-Promoted Locomotion

Turley, Eva A.; Austen, L; Moore, Dan H.; Hoare, Kishalay

doi:10.1006/excr.1993.1194

Cited by 65 publications

(45 citation statements)

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“…In the first place, although CD44H appears to be the major receptor for hyaluronan on the surface of B16F10 cells, it has been shown in other studies that minor proportions of hyaluronan binding to the RHAMM receptor can, in some cases, have a dominant effect on cell behavior (Turley et al, 1993). Second, in the present study, high concentrations of both hyaluronan oligomers and polymer were observed to inhibit B16F10 cell proliferation in vitro.…”

Section: Hyaluronan Oligomers Inhibit Tumor Growth In Vivosupporting

confidence: 48%

Inhibition of tumor growth in vivo by hyaluronan oligomers

Zeng

Toole

Kinney³

et al. 1998

Int. J. Cancer

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One of the critical events in tumor growth and metastasis is the interaction between tumor cells and host tissue stroma, mediated by different adhesion receptor repertoires in different tumor cell types. Several lines of evidence indicate that interaction between the hyaluronan receptor CD44, expressed on tumor cells, and host tissue stromal hyaluronan can enhance growth and invasiveness of certain tumors. Disruption of CD44-hyaluronan interaction by soluble recombinant CD44 has been shown to inhibit tumor formation by lymphoma and melanoma cells transfected with CD44. Since hyaluronan is a ubiquitous glycosaminoglycan polymer from which oligosaccharides of defined size can be readily purified, we tested the ability of hyaluronan oligomers to inhibit tumor formation by subcutaneously (s.c.) injected B16F10 melanoma cells. Our results indicate that hyaluronan oligomers injected at concentrations as low as 1 mg/ml can markedly inhibit B16F10 melanoma growth, providing a potentially attractive reagent for the control of local tumor development. Int.

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Section: Hyaluronan Oligomers Inhibit Tumor Growth In Vivosupporting

confidence: 48%

Inhibition of tumor growth in vivo by hyaluronan oligomers

Zeng

Toole

Kinney³

et al. 1998

Int. J. Cancer

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“…However, another GAG type, hyaluronic acid (HyA) has been shown to contribute to the migration and proliferation of MSCs and chondrocytes via association with specific cell surface receptors such as CD44 and RHAMM (Receptor for Hyaluronic Acid Mediated Migration) (Turley et al, 1993, Zhu et al, 2006, Toole, 2001. Moreover, the presence of HyA within scaffolds has been shown to create a chondroinductive environment in vitro and in vivo promoting synthesis of cartilage tissue (Wu et al, 2010, Correia et al, 2011, Nehrer et al, 2006, Welsch et al, 2010.…”

Section: Introductionmentioning

confidence: 99%

Addition of hyaluronic acid improves cellular infiltration and promotes early-stage chondrogenesis in a collagen-based scaffold for cartilage tissue engineering

Matsiko

Levingstone

O’Brien

et al. 2012

Journal of the Mechanical Behavior of Biomedical Materials

142

102

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“…CD168, a RHAMM, has a dual function as an extracellular and an intracellular hyaluronan-binding-protein (25,26). Hyaluronan serves an important role in tissue organization and in cellular migration, growth and differentiation (27).…”

Section: Discussionmentioning

confidence: 99%

Expression patterns of CD168 correlate with the stage and grade of squamous cell carcinoma of head and neck

Jöhrens

Anagnostopoulos

Dommerich

et al. 2017

Molecular and Clinical Oncology

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Abstract. The receptor for hyaluronan-mediated motility CD168 is associated with the processes of oncogenesis and metastasis. The objective of the present study was to determine the possible association between the expression and distribution of CD168 and the tumor stage of head-and-neck squamous cell carcinoma (SCC). Formalin-fixed and paraffinembedded tumor samples obtained from 100 patients during primary resection of SCC from the oral cavity, oropharynx, hypopharynx or larynx were included in the present study. The patients were divided into two risk groups: Low risk, representing the early stage of completely resected SCCs with good-to-moderate differentiation, and the high-risk group, representing the advanced stage SCCs with positive resection margins, vascular invasion or locoregional metastasis. All specimens were stained with a monoclonal antibody against CD168. Percentage and staining intensity of CD168-positive cells were scored, and their spatial distribution within the tumor nests was noted. The results obtained were correlated with the tumor stage. The quantification of CD168 expression revealed significant differences between the two risk groups (t-test, P=0.002), with higher scores in tumors resected from the highrisk SSC group compared with those from the low-risk group. In addition, in the high-risk group, the CD168-positive cells were present predominantly in the periphery (70.4%) of tumor nests, whereas in the low-risk group, only 56.6% were located there; however, this trend did not reach the level of statistical significance. Taken together, the results from the present study suggested that CD168 expression patterns could potentially be used as a predictor of tumor aggressiveness, and therefore they may be a prognostic factor in head-and-neck SCC.

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Ras-Transformed Cells Express Both CD44 and RHAMM Hyaluronan Receptors: Only RHAMM Is Essential for Hyaluronan-Promoted Locomotion

Cited by 65 publications

References 0 publications

Inhibition of tumor growth in vivo by hyaluronan oligomers

Inhibition of tumor growth in vivo by hyaluronan oligomers

Addition of hyaluronic acid improves cellular infiltration and promotes early-stage chondrogenesis in a collagen-based scaffold for cartilage tissue engineering

Expression patterns of CD168 correlate with the stage and grade of squamous cell carcinoma of head and neck

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