Rat Cartilage Repair Using Nanophase PLGA/HA Composite and Mesenchymal Stem Cells

Hua-de, LI; Zheng, Qiang; Xiao, Yu; Feng, Jie; Shi, Zhijun; Pan, Zhijun

doi:10.1177/0883911508100655

Cited by 27 publications

(4 citation statements)

References 35 publications

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“…of studies using the score (%)ReferencesHistology scores111 (100%)[49, 54–102, 134, 150–154, 160, 161, 272–324]International Cartilage Repair Society Score26 (23%)[49, 60, 61, 63, 66, 69, 72, 74, 79, 89, 92, 94, 98, 99, 272, 282, 283, 289, 305, 306, 310, 313, 314, 316, 319, 324]Wakitani score21 (19%)[58, 62, 67, 68, 72, 73, 80, 82, 97, 151, 273, 277, 279, 284, 285, 290, 299, 304, 310, 321]O’Driscoll score2018%[49, 71, 81, 84, 85, 93, 100, 160, 272, 276, 290, 296–298, 302, 306, 308, 313, 314, 322]Functional scores/mechanical11 (10%)[55, 57, 62, 67, 69, …”

Section: Resultsmentioning

confidence: 99%

“…The pre-clinical data with regards to allogenic cells is conflicting. One group showed promising results of allogenic MSCs in a rabbit model when compared to autologous cells, although numbers were small [ 160 , 161 ]. Another group compared autologous chondroprogenitor cells and allogenic chondroprogenitor cells against controls in an equine model and reported inferior repair in the allogenic cell group [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…of studies using the score (%) References Histology scores 111 (100%) [ 49 , 54 – 102 , 134 , 150 – 154 , 160 , 161 , 272 – 324 ] International Cartilage Repair Society Score 26 (23%) [ 49 , 60 , 61 , 63 , 66 , 69 , 72 , 74 , 79 , 89 , 92 , 94 , 98 , 99 , 272 , 282 , 283 , 289 , 305 , 306 , 310 , 313 , 314 , 316 , 319 , 324 ] Wakitani score 21 (19%) [ 58 , 62 , 67 , 68 , 72 , 73 , 80 , 82 , 97 , 151 , 273 , 277 , 279 , 284 ...…”

Section: Main Textmentioning

confidence: 99%

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The use of mesenchymal stem cells for cartilage repair and regeneration: a systematic review

et al. 2017

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BackgroundThe management of articular cartilage defects presents many clinical challenges due to its avascular, aneural and alymphatic nature. Bone marrow stimulation techniques, such as microfracture, are the most frequently used method in clinical practice however the resulting mixed fibrocartilage tissue which is inferior to native hyaline cartilage. Other methods have shown promise but are far from perfect. There is an unmet need and growing interest in regenerative medicine and tissue engineering to improve the outcome for patients requiring cartilage repair. Many published reviews on cartilage repair only list human clinical trials, underestimating the wealth of basic sciences and animal studies that are precursors to future research. We therefore set out to perform a systematic review of the literature to assess the translation of stem cell therapy to explore what research had been carried out at each of the stages of translation from bench-top (in vitro), animal (pre-clinical) and human studies (clinical) and assemble an evidence-based cascade for the responsible introduction of stem cell therapy for cartilage defects.Main body of abstractThis review was conducted in accordance to PRISMA guidelines using CINHAL, MEDLINE, EMBASE, Scopus and Web of Knowledge databases from 1st January 1900 to 30th June 2015. In total, there were 2880 studies identified of which 252 studies were included for analysis (100 articles for in vitro studies, 111 studies for animal studies; and 31 studies for human studies). There was a huge variance in cell source in pre-clinical studies both of terms of animal used, location of harvest (fat, marrow, blood or synovium) and allogeneicity. The use of scaffolds, growth factors, number of cell passages and number of cells used was hugely heterogeneous.Short conclusionsThis review offers a comprehensive assessment of the evidence behind the translation of basic science to the clinical practice of cartilage repair. It has revealed a lack of connectivity between the in vitro, pre-clinical and human data and a patchwork quilt of synergistic evidence. Drivers for progress in this space are largely driven by patient demand, surgeon inquisition and a regulatory framework that is learning at the same pace as new developments take place.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…of studies using the score (%) References Histology scores 111 (100%) [ 49 , 54 – 102 , 134 , 150 – 154 , 160 , 161 , 272 – 324 ] International Cartilage Repair Society Score 26 (23%) [ 49 , 60 , 61 , 63 , 66 , 69 , 72 , 74 , 79 , 89 , 92 , 94 , 98 , 99 , 272 , 282 , 283 , 289 , 305 , 306 , 310 , 313 , 314 , 316 , 319 , 324 ] Wakitani score 21 (19%) [ 58 , 62 , 67 , 68 , 72 , 73 , 80 , 82 , 97 , 151 , 273 , 277 , 279 , 284 ...…”

Section: Main Textmentioning

confidence: 99%

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The use of mesenchymal stem cells for cartilage repair and regeneration: a systematic review

et al. 2017

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“…But, due to the deficiency of the natural strength of molecular recognition sites on the PLGA side, they can bound the PLGA application in the medical area to a specific point and inhibit the specific cell adhesion (Chen et al, 2006;Hsu et al, 2006;Zhang et al, 2016). Therefore, materials with higher cell affinity, for example, hydroxyapatite and collagen, are mostly reformed with PLGA for the enhancement of biocompatibility (Kawazoe et al, 2009;Li, Zheng, et al, 2009). Wool keratin is a natural biomaterial (Tachibana et al, 2002(Tachibana et al, , 2005Yamauchi et al, 1996;Zhang et al, 2016).…”

Section: Promote the Bone Regenerationmentioning

confidence: 99%

Recent progress in materials development and biological properties of GTR membranes for periodontal regeneration

et al. 2021

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Chronic periodontal is a very common infection that instigates the destruction of oral tissue, and for its treatment, it is necessary to minimize the infection and the defects regeneration. Periodontium consists of four types of tissues: (a) cementum, (b) periodontal ligament, (c) gingiva, and 4) alveolar bone. In separated cavities, regenerative process also allows various cell proliferations. Guided tissue regeneration (GTR) is a potential procedure that favors periodontal regrowth; however, some limitations (such as ineffective hemostatic property, poor mechanical property, and improper biodegradation) are also associated with it. This review mainly emphasizes on the following areas: (a) a summarized overview of the periodontium and its immunological situations, (b) recently utilized treatments for regeneration of distinctive periodontal tissues; (c) an overview of GTR membranes available commercially, and the latest developments on the characterization and processing of GTR membrane material; and 4) the function of the different nonpolymeric/polymeric materials, which are acting as drug carriers, antibacterial agents, nanoparticles, and periodontal barrier membranes to prevent periodontal inflammation and to improve the strength of the GTR membrane.

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Effect of bamboo fiber on the degradation behavior and in vitro cytocompatibility of the nano-hydroxyapatite/poly(lactide-co-glycolide) (n-HA/PLGA) composite

Liuyun

et al. 2018

Cellulose

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Rat Cartilage Repair Using Nanophase PLGA/HA Composite and Mesenchymal Stem Cells

Cited by 27 publications

References 35 publications

The use of mesenchymal stem cells for cartilage repair and regeneration: a systematic review

The use of mesenchymal stem cells for cartilage repair and regeneration: a systematic review

Recent progress in materials development and biological properties of GTR membranes for periodontal regeneration

Effect of bamboo fiber on the degradation behavior and in vitro cytocompatibility of the nano-hydroxyapatite/poly(lactide-co-glycolide) (n-HA/PLGA) composite

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