Rat somatosensory cerebropontocerebellar pathways: Spatial relationships of the somatotopic map of the primary somatosensory cortex are preserved in a three-dimensional clustered pontine map

Leergaard, Trygve B.; Lyngstad, Kjersti A.; Thompson, John H.; Taeymans, Sofie; Vos, Bart P.; Schutter, Erik De; Bower, James M.; Bjaalie, Jan G.

doi:10.1002/(sici)1096-9861(20000626)422:2<246::aid-cne7>3.0.co;2-r

Cited by 74 publications

(112 citation statements)

References 80 publications

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“…5E-G), tight point clusters representing terminal labeling made it possible to choose an isodensity surface that excluded only ϳ5% of the terminal labeling. The results closely match those previously reported by Leergaard et al (2000a). A visual comparison of the 3-D shapes generated for the pontocerebellar cell distributions with those produced by the SI cerebropontine terminal fields clearly demonstrates similarities between the cell populations and their corresponding SI projections: both in terms of their 3-D shape and location within the contralateral pontine nuclei and in terms of the relative positions of territories associated with different projections.…”

Section: Comparison Between the Spatial Distributions Of Pontocerebelsupporting

confidence: 88%

“…As in previous studies (for example, see Leergaard et al, 2000a), the distributions of labeled cells in the pontine nuclei for each case were shown as dot maps in the pontine coordinate system displayed in three different angles of view (see Fig. 2; the data were also resliced in multiple user-defined section planes for detailed visual analyses; see http:// www.nesys.uio.no/Database for additional details).…”

Section: Methodsmentioning

confidence: 99%

“…The cerebropontine results were obtained from a data archive at http://www.nesys.uio.no/Database [introduced and analyzed previously for another purpose by Leergaard et al (2000a)]. The archive contains cerebropontine data based on anterograde tracer injections made into different electrophysiologically identified locations within SI cortex.…”

Section: Methodsmentioning

confidence: 99%

“…The latter results have been published previously (Leergaard et al 2000a) and were obtained from a data archive available at http://www.nesys.uio.no/Database. A total of five cerebropontine cases were selected from the archive.…”

Section: Comparison Between the Spatial Distributions Of Pontocerebelmentioning

confidence: 98%

“…Each plot in Figure 4, B, D, and F, shows the distribution and relative density of terminal labeling arising from these different injections into SI. The density of points represents an estimate of the number of labeled preterminal fibers within a given pontine region (for additional details of the semiquantitative mapping procedure, see Leergaard et al, 2000a).…”

Section: Comparison Between the Spatial Distributions Of Pontocerebelmentioning

confidence: 99%

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Pontine Maps Linking Somatosensory and Cerebellar Cortices Are in Register with Climbing Fiber Somatotopy

Odeh

Ackerley²,

Bjaalie³

et al. 2005

Journal of Neuroscience

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The cerebropontocerebellar mossy fiber system is a major CNS sensorimotor pathway. We used a double-retrograde axonal tracing technique (red and green beads) to chart in rats the pontocerebellar projection to different electrophysiologically defined climbing fiber zones in the posterior lobe (face-receiving A2 zone and forelimb-and hindlimb-receiving parts of the C1 zone in the paramedian lobule and copula pyramidis, respectively). Individual cortical injection sites were verified as located in a given zone by mapping the pattern of cell labeling in the inferior olive, whereas labeled cells in the pontine nuclei were mapped using computer-aided three-dimensional reconstruction techniques. A number of topographical differences were found for the pontine projection to the individual zones. Projections to the A2 zone were bilateral, whereas to both parts of the C1 zone, the inputs were mainly contralateral. Furthermore, the A2 (face), C1 (forelimb), and C1 (hindlimb) zone projections were centered in progressively more caudal parts of the pontine nuclei with little or no overlap between them. The areas occupied by cell labeling for each zone corresponded closely to territories in the pontine nuclei shown previously to receive projections from somatotopically equivalent regions of the somatosensory cortex. This precise cerebropontocerebellar topography, defined by climbing fiber somatotopy, is a new principle of organization for linking somatosensory and cerebellar cortices. The convergence of direct and indirect sensory projections is likely to have important implications for cerebellar cortical processing.

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Section: Comparison Between the Spatial Distributions Of Pontocerebelsupporting

confidence: 88%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Comparison Between the Spatial Distributions Of Pontocerebelmentioning

confidence: 98%

Section: Comparison Between the Spatial Distributions Of Pontocerebelmentioning

confidence: 99%

See 3 more Smart Citations

Pontine Maps Linking Somatosensory and Cerebellar Cortices Are in Register with Climbing Fiber Somatotopy

Odeh

Ackerley²,

Bjaalie³

et al. 2005

Journal of Neuroscience

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Spatial arrangement of cerebro‐pontine terminals

Schwarz

Möck

2001

J of Comparative Neurology

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Understanding the interaction of the cerebral cortex and cerebellum requires knowledge of the highly complex spatial characteristics of cerebro-cerebellar signal transfer. Cerebro-pontine fibers from one neocortical site terminate in several sharply demarcated patches across large parts of the pontine nuclei (PN), and fibers from different neocortical areas terminate in the same pontine region. To determine whether projections from segregated neocortical sites overlap in the PN, we studied double anterograde tracing of cerebro-pontine terminals from large parts of rat neocortex. In none of these experiments, including double injection into two functionally related areas, were we able to demonstrate overlapping patches, although close spatial relationships were always detected. This non-overlapping distribution is consistent with a compartmentalized organization of the cerebro-pontine projection and may be the basis of the fractured type of maps found in the cerebellar granular layer. The critical distance between two sites on the neocortical surface that project to non-overlapping patches in the PN was found to be 600 microm, by using double injection within the whisker representation of the primary somatosensory area. This matches the diameter of dendritic trees of layer 5 projection neurons, indicating that non-overlapping populations of neocortical projection neurons possess non-overlapping patches of pontine terminals. Estimations based on this critical distance and the pontine volume anterogradely labeled by one injection site indicate that the size of the PN may be well suited to accommodate a complete set of non-overlapping pontine patches from all possible neocortical sites.

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Projections of the pontine nuclei to the cochlear nucleus in rats

Ohlrogge

Doucet

Ryugo

2001

J of Comparative Neurology

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In the cochlear nucleus, there is a magnocellular core of neurons whose axons form the ascending auditory pathways. Surrounding this core is a thin shell of microneurons called the granule cell domain (GCD). The GCD receives auditory and nonauditory inputs and projects in turn to the dorsal cochlear nucleus, thus appearing to serve as a central locus for integrating polysensory information and descending feedback. Nevertheless, the source of many of these inputs and the nature of the synaptic connections are relatively unknown. We used the retrograde tracer Fast Blue to demonstrate that a major projection arises from the contralateral pontine nuclei (PN) to the GCD. The projecting cells are more densely located in the ventral and rostral parts of the PN. They also are clustered into a lateral and a medial group. Injections of anterograde tracers into the PN labeled mossy fibers in the contralateral GCD. The terminals are confined to those parts of the GCD immediately surrounding the ventral cochlear nucleus. There is no PN projection to the dorsal cochlear nucleus. These endings have the form of bouton and mossy fiber endings as revealed by light and electron microscopy. The PN represent a key station between the cerebral and cerebellar cortices, so the pontocochlear nucleus projection emerges as a significant source of highly processed information that is introduced into the early stages of the auditory pathway. The cerebropontocerebellar pathway may impart coordination and timing cues to the motor system. In an analogous way, perhaps the cerebropontocochlear nucleus projection endows the auditory system with a timing mechanism for extracting temporal information.

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Rat somatosensory cerebropontocerebellar pathways: Spatial relationships of the somatotopic map of the primary somatosensory cortex are preserved in a three-dimensional clustered pontine map

Cited by 74 publications

References 80 publications

Pontine Maps Linking Somatosensory and Cerebellar Cortices Are in Register with Climbing Fiber Somatotopy

Pontine Maps Linking Somatosensory and Cerebellar Cortices Are in Register with Climbing Fiber Somatotopy

Spatial arrangement of cerebro‐pontine terminals

Projections of the pontine nuclei to the cochlear nucleus in rats

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