Ratio Fluorescent Detecting of Tryptophan and Its Metabolite 5‐Hydroxyindole‐3‐acetic Acid Relevant with Depression via Tb(III) Modified HOFs Hybrids: Further Designing Recyclable Molecular Logic Gate Connected by Back Propagation Neural Network

Abstract

Exploring intelligent fluorescent materials with high reliability and precision to diagnose diseases is significant but remains a great challenge. Herein, based on coordination post-synthetic modification, a Tb 3+ functionalized ME-PA (Tb@1) is prepared, which can emit brilliant green fluorescence through ligand-to-mental charge transfer-assisted energy transfer (LMCT-ET) process from ME-PA to Tb 3+ ions. Tb@1 can simultaneously distinguish Tryptophan (Try) and its metabolite 5-hydroxyindole-3-acetic acid (5-HIAA), two effective indicators for depression, in ratio and colorimetric mode. And this sensor behaves the advantages of high efficiency and sensitivity, as well as excellent reusability and anti-interference. The PET process from ME to Try and 5-HIAA, and the competitive absorption between analytes and Tb@1 may be relevant to sensing mechanism. In realistic serum or urine environment, the detection limits of Tb@1 for Try and 5-HIAA are 0.0183 and 0.0149 mg L −1 respectively. Moreover, in conjunction with back propagation neural network (BPNN), two dual-output molecular logic gates that can be calculated circularly are further designed, which realizes intelligent control of the electronic component to identify the existence of two biomarkers and judge their concentrations from fluorescence images. This work offers a novel approach to modulate logic circuits based on ML-assisted HOF fluorescent sensor, with promising application for a precise and pictorial depression diagnosis.

Convolution Neural Network-Assisted Smart Fluorescent-Tongue Based on Lanthanide Ion-Induced Forming MOF/HOF Composite for Differentiation of Flavor Compounds and Wine Identification

“…The red shifts of the N–H stretching vibration absorption peaks of MA from 3416 and 3321 cm –1 to 3389 and 3227 cm –1 together with that of the C–O stretching vibration absorption peak of BTC from 1714 to 1699 cm –1 indicate the formation of O–H···N hydrogen bonds in the MA-BTC HOF (Figure S5). After postsynthetic modification, the absorption band at 1424 cm –1 can be ascribed to the triazine ring CN stretching vibration shifts to 1437 cm –1 in 1 , which may result from the chelation interactions between Tb 3+ ions and amino groups of MA . Meanwhile, there exists a new absorption peak at around 1382 cm –1 in 1 which accounts for the similar coordination mode between Tb 3+ ions and carboxyl group with Tb-MOF.…”

“…After introducing Ln 3+ ions into the MA-BTC HOF, the optimum excitation wavelength of Ln-MOF/HOF blue shifts to 295 nm, which may be attributed to the coordination interaction between Tb 3+ and HOF leading to the enlarged energy gap (Figure S9). Under this excitation, the fluorescence emission intensity of 1 with a HOF/Ln 3+ molar ratio of 7:1 is weakest, but the others do not enhance it significantly with increasing molar ratio (Figure S10). Hence, the Ln-MOF/HOF (HOF/Ln 3+ molar ratio = 7:1) is a good choice for the following experiments.…”

Visual Detection of Coumarin and Umbelliferone for Beverage Safety Based on Eu(III)‐Functionalized HOF Hybrids: Further Constructing an SVM‐Assisted Digital Anti‐Counterfeiting Platform

“…Intelligent fluorescent materials (IFMs) [21][22][23][24] exhibit dynamic and selective responses to their external environment changes. [25,26] These materials have attracted considerable attention in the field of advanced materials owing to their potential applications in fluorescence sensing, [27,28] information anticounterfeiting, [29][30][31][32] luminescent devices, [33,34] and biological imaging. [35,36] Hydrogen-bonded organic frameworks (HOFs) are a burgeoning class of crystalline porous materials that are selfassembled from organic building blocks via hydrogen-bonding interactions, 𝜋•••𝜋 interactions, and van der Waals forces.…”

“…[41] Yan et al prepared a series of Ln@HOFs utilized for gases, [51] volatile organic pollutants, [52] and biomarkers monitoring. [28] Accordingly, luminescent Ln@HOFs are potential candidates for crystalline IFMs.…”

Multifunctional Eu(iii)-modified HOFs: roxarsone and aristolochic acid carcinogen monitoring and latent fingerprint identification based on artificial intelligence

“…29 In addition, there are massive unpaired and residual hydrogen-bonding donor and acceptor groups in the HOF structures, which enables the incorporation of lanthanide ions (Ln 3+ ) into their frameworks through facile post-synthetic modification (PSM) to prepare Ln@HOFs. 30,31 Ln@HOFs show the advantages of high luminous quantum yield, narrow emission bands, long excitation life, and large Stokes shifts of luminescence. 32,33 In particular, for Eu@HOFs, the brilliant red fluorescence can avoid blue fluorescence interference from most substrate materials.…”