2023
DOI: 10.1021/acs.chemrev.2c00822
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Rational Design of Biomaterials to Potentiate Cancer Thermal Therapy

Abstract: Cancer thermal therapy, also known as hyperthermia therapy, has long been exploited to eradicate mass lesions that are now defined as cancer. With the development of corresponding technologies and equipment, local hyperthermia therapies such as radiofrequency ablation, microwave ablation, and high-intensity focused ultrasound, have has been validated to effectively ablate tumors in modern clinical practice. However, they still face many shortcomings, including nonspecific damages to adjacent normal tissues and… Show more

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Cited by 78 publications
(36 citation statements)
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“…In this way, it becomes possible to automatically monitor and adjust collective motions and treatment parameters of the HT-NRs in real time based on the received visual structural-color feedback, realizing automatic and precise motile-targeting feedback PTT. In addition, the photothermal conversion of the HT-NRs can be further enhanced by grafting highly efficient photothermal agents (e.g., polydopamine, polylactic acid, transition-metal chalcogenides, and Au nanoparticles) onto the nanorobot surface or embedding them in their hydrogel matrix, 68 thereby reducing the required NIR power density while enhancing the efficacy of PTT.…”
Section: Resultsmentioning
confidence: 99%
“…In this way, it becomes possible to automatically monitor and adjust collective motions and treatment parameters of the HT-NRs in real time based on the received visual structural-color feedback, realizing automatic and precise motile-targeting feedback PTT. In addition, the photothermal conversion of the HT-NRs can be further enhanced by grafting highly efficient photothermal agents (e.g., polydopamine, polylactic acid, transition-metal chalcogenides, and Au nanoparticles) onto the nanorobot surface or embedding them in their hydrogel matrix, 68 thereby reducing the required NIR power density while enhancing the efficacy of PTT.…”
Section: Resultsmentioning
confidence: 99%
“…around 48 1C, the major type of cell death changes from apoptosis to necrosis. 56 However, tumor blood vessels are often unorganized and dysfunctional. Leaky tumor vessels and low blood flow are found in tumor tissues compared to normal vessels of normal tissues, meaning that tumors cannot diffuse heat by increasing blood flow during hyperthermia treatment.…”
Section: Photothermal Therapy (Ptt)mentioning
confidence: 99%
“…According to the previous findings, cells undergo apoptosis within the temperature range 42–46 °C. 56 While above a certain threshold temperature, i.e. around 48 °C, the major type of cell death changes from apoptosis to necrosis.…”
Section: Photothermal Therapy (Ptt)mentioning
confidence: 99%
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