Rational Design of Intelligent and Multifunctional Dressing to Promote Acute/Chronic Wound Healing

Abstract

Currently, the clinic's treatment of acute/chronic wounds is still unsatisfactory due to the lack of functional and appropriate wound dressings. Intelligent and multifunctional dressings are considered the most advanced wound treatment modalities. It is essential to design and develop wound dressings with required functions according to the wound microenvironment in the clinical treatment. This work summarizes microenvironment characteristics of various common wounds, such as acute wound, diabetic wound, burns wound, scalded wound, mucosal wound, and ulcers wound. Furthermore, the factors of transformation from acute wounds to chronic wounds were analyzed. Then we focused on summarizing how researchers fully and thoroughly combined the complex microenvironment with modern advanced technology to ensure the usability and value of the dressing, such as photothermal-sensitive dressings, microenvironment dressing (pH-sensitive dressings, ROSsensitive dressings, and osmotic pressure dressings), hemostatic dressing, guiding tissue regeneration dressing, microneedle dressings, and 3D/4D printing dressings. Finally, the revolutionary development of wound dressings and how to transform the existing advanced functional dressings into clinical needs as soon as possible have carried out a reasonable and meaningful outlook.

New techniques and methods for prevention and treatment of symptomatic traumatic neuroma: A systematic review

“…Although stem cells are rich in resources and advanced in extraction technology, stem cells gradually lose the ability of directional differentiation after long-term in vitro culture. The current method was to encapsulate stem cells in three-dimensional (3D) spheres to maintain and promote the stemness of stem cells, which can play a paracrine effect in three-dimensional space due to hypoxia ( Figure 5A ) ( 47 ). Furthermore, stemness maintenance could also be realized by adding growth factors or drugs ( Figure 5B ) ( 47 ).…”

“…The current method was to encapsulate stem cells in three-dimensional (3D) spheres to maintain and promote the stemness of stem cells, which can play a paracrine effect in three-dimensional space due to hypoxia ( Figure 5A ) ( 47 ). Furthermore, stemness maintenance could also be realized by adding growth factors or drugs ( Figure 5B ) ( 47 ). Otherwise, bone marrow stem cells are the first seed cells to conduct clinical application research.…”

Healing Wounds Efficiently with Biomimetic Soft Matter: Injectable Self-Healing Neutral Glycol Chitosan/Dibenzaldehyde-Terminated Poly(ethylene glycol) Hydrogel with Inherent Antibacterial Properties

“…That said, new modalities of hydrogel wound dressings have been engineered and deemed intelligent by tailoring them to perform multiple functions. 19,20 Our previous work was the very first study to develop acrylamide-modified β-chitin-based biocompatible hydrogels with both self-healing and accelerated wound-healing properties directly from sustainable squid gladii waste. 21,22 Our current study developed hydrogels by crosslinking neutral glycol chitosan with synthesized dibenzaldehyde-terminated polyethylene glycol derivatives to form Schiff base hydrogels with remarkable injectability, biocompatibility, self-healing properties, antibacterial activity, and the ability to promote accelerated wound healing.…”

“…As previously emphasized, despite vigorous efforts and current developments that placed hydrogels at the forefront of biomaterials for wound-healing acceleration, their susceptibility to mechanical stress during use is still left unaided; that is to say, hydrogels can either serve as wound dressings or exhibit self-healing properties but scarcely a hybrid of both properties. That said, new modalities of hydrogel wound dressings have been engineered and deemed intelligent by tailoring them to perform multiple functions. , Our previous work was the very first study to develop acrylamide-modified β-chitin-based biocompatible hydrogels with both self-healing and accelerated wound-healing properties directly from sustainable squid gladii waste. , Our current study developed hydrogels by cross-linking neutral glycol chitosan with synthesized dibenzaldehyde-terminated polyethylene glycol derivatives to form Schiff base hydrogels with remarkable injectability, biocompatibility, self-healing properties, antibacterial activity, and the ability to promote accelerated wound healing. To put an accent on the novelty of this work, the main thrust is zeroing in on the inherent multistrain antibacterial property of our synthesized glycol-chitosan-based hydrogels, without the addition of any antibiotics, and their notable wound-healing efficiency using zebrafish as a model system.…”

Light-Mediated 3D Printing of Micro-Pyramid-Decorated Tailorable Wound Dressings with Endogenous Growth Factor Sequestration for Improved Wound Healing

“…Although the thick hydrogels add bulk to the wound, they also lead to improper gaseous and nutrient exchange along with providing a barrier for the cells to migrate easily, which again is quite a prominent characteristic of wound healing, thus again leaving the wound unhealed. In addition to these challenges for a deep wound, management of large irregular wounds is also challenging as the available dressings lack customizability for personalized wound care. , Therefore, multifunctional customizable wound dressings, which can play with the kinetics of wound healing and modulate the biological processes, are still anticipated. − …”