Rational synthesis and characterization of medicinal phenyl diazenyl-3-hydroxy-1h-inden-1-one azo derivatives and their metal complexes

Naseem, Hafiza Ammara; Aziz, T.; Shah, Habib-ur-Rehman; Ahmad, Khalil; Parveen, Sajidah; Ashfaq, Muhammad

doi:10.1016/j.molstruc.2020.129574

Cited by 21 publications

(9 citation statements)

References 38 publications

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“…As a result of the preceding explanation, it is concluded that azo ligands can exist in the azo‐enol form and act as bidentate ligands during chelation. [ 47 ]…”

Section: Resultsmentioning

confidence: 99%

Ag(I), In (III), and Sn (II) chelates of azo mesalamine drug: Characterization, DFT studies, molecular docking and biological evaluation

Elaziz

Gaber

El-Wakiel

et al. 2022

Applied Organom Chemis

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A new set of Ag(I), In (III) and Sn (II) chelates based on azo dye ligand of 5-aminosalicylic acid (H 2 L) were prepared. The structures of this novel chelates have already been confirmed by elemental analysis, thermogravimetric analysis, molar conductance, X-ray diffraction (XRD), UV-Vis, Fourier-transform infrared spectroscopy (FT-IR), and mass spectra. The lower conductivity values showed the non-electrolytic nature. The kinetic and thermodynamic parameters were determined through using Coats-Redfern model, also, potential application; the antibacterial activity of the target compounds was tested by examining their effect on the development of various strains of bacteria. Utilizing UV-visible absorption measurements, we investigated the interaction between calf thymus DNA and the evaluated compounds. According to the findings, the intercalative binding approach, the chelates interact with DNA by assessing the binding constants. Additionally, the in vitro antimicrobial properties of the ligand and its metal chelates were evaluated. The theoretical density functional theory (DFT) simulations for the azo dye ligand (H 2 L) were completed by using B3LYP/6-311G ++ (d,p) basis functions, and the B3LYP/LanL2DZ for Ag(I), In (III), and Sn (II) chelatesshows that the uninuclear Ag(I) and Sn(II) chelates under consideration have a tetrahedral geometry. Although the experimental data are in agreement with the octahedral shape for binuclear In (III) chelate. Molecular docking simulations were carried out using molecular operating environment (MOE) software for the ligand and its chelates. Docking simulation results indicated that the Ag(I) chelate was more potent and exhibited a higher affinity for the (3QKK) protein than the In (III) and Sn (II) chelates. This is in agreements with the biological evaluations under studies.

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“…As a result of the preceding explanation, it is concluded that azo ligands can exist in the azo‐enol form and act as bidentate ligands during chelation. [ 47 ]…”

Section: Resultsmentioning

confidence: 99%

Ag(I), In (III), and Sn (II) chelates of azo mesalamine drug: Characterization, DFT studies, molecular docking and biological evaluation

Elaziz

Gaber

El-Wakiel

et al. 2022

Applied Organom Chemis

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“…The metal chelates were synthesized according to the procedure followed by H. Ammara et al [ 42 ] and K. Ahmad et al [ 41 ] with some modifications at pH = 8 as given in Scheme 2 . Azo ligands (2 mmol) were dissolved in ethanol (30 mL) and then solution of metal chlorides also added (1mmol) Cu(II), Ni(II), Zn(II), Mn(II)) color changes at once.…”

Section: Methodsmentioning

confidence: 99%

“…Antioxidant activities of understudy azo derivatives, their metal complexes was determined by adopting reported procedure by H. Ammara et.al [ 42 , 48 ]. For this purpose, 0.3 mmol solution of DPPH was prepared by mixing 11.5 mg of DPPH in ethanol and kept in dark.…”

Section: Methodsmentioning

confidence: 99%

Rational synthesis, biological screening of azo derivatives of chloro-phenylcarbonyl diazenyl hydroxy dipyrimidines/thioxotetrahydropyrimidines and their metal complexes

Aziz

Nasim

Ahmad

et al. 2023

Heliyon

Self Cite

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“…Different industries, involving electrication, tanneries, mining, metal processing, smelting, battery production, etc., have generated huge amount of heavy metals in wastewater. [1][2][3][4] Heavy metal wastewater is present in the environment in the form of direct or indirect approaches, such as river sediment, rainfall-runoff, domestic, industrial, and agricultural effluents, and atmospheric deposition. [5][6][7][8] Bulgariu et al presented that numerous heavy metals are carcinogenic and toxic.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Fe-THC MOFs and functionalizing MOFs by MXenes for the selective removal of lead(ii) ions from wastewater

et al. 2023

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Rational synthesis and characterization of medicinal phenyl diazenyl-3-hydroxy-1h-inden-1-one azo derivatives and their metal complexes

Cited by 21 publications

References 38 publications

Ag(I), In (III), and Sn (II) chelates of azo mesalamine drug: Characterization, DFT studies, molecular docking and biological evaluation

Ag(I), In (III), and Sn (II) chelates of azo mesalamine drug: Characterization, DFT studies, molecular docking and biological evaluation

Rational synthesis, biological screening of azo derivatives of chloro-phenylcarbonyl diazenyl hydroxy dipyrimidines/thioxotetrahydropyrimidines and their metal complexes

Synthesis of Fe-THC MOFs and functionalizing MOFs by MXenes for the selective removal of lead(ii) ions from wastewater

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