Ratlarda Cyclophosphamide ile İndüklenen Nefrotoksisitede Bazı Hematolojik Parametreler ve Böbreğin Histopatolojisi Üzerine Naringinin Protektif Etkileri

Dağ, Yusuf; Şengül, Emin; Selçuk, Muzaffer; Yıldırım, Serkan; Çelebi, Fikret; Çınar, Ali

doi:10.17094/ataunivbd.384225

Cited by 4 publications

(8 citation statements)

References 32 publications

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“…Serum urea and creatinine levels are biomarkers of kidney function, and serum levels increase when kidney tissue is damaged. (Chahdoura et al 2018;Dağ et al 2018;Sengul et al 2021). According to the data we obtained in our study, liver urea, creatinine, ALT, AST, and total bilirubin increased signi cantly in the 5-FU group compared to the control group.…”

Section: Immunohistochemical Ndingsmentioning

confidence: 99%

Investigation of Effects of Silymarin in 5-Fluorouracil Hepatotoxicity and Nephrotoxicity in Mice

Şengül

Gelen

Yıldırım

et al. 2021

Preprint

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Hepatotoxicity and nephrotoxicity are common side effects of 5-Fluorouracil (5-FU). The present study aimed to investigate the effects of Silymarin (SLY) on 5-FU induced hepatotoxicity and nephrotoxicity in mice. In our study, 10 mice in each group were randomly divided into four groups as the control group, 5-FU, SLY50+5-FU, and SLY100+5-FU group. SLY50+5-FU and SLY100+5-FU groups were administered at a dose of 50 and 100 mg/kg for seven days, respectively. 5-FU was administered at a dose of 400 mg/kg intraperitoneally on the fourth day. After the applications, the mice were decapitated under anesthesia. The liver and kidney functions which urea, creatinine, AST, ALT, and total bilirubin levels were analyzed in serum. In liver and renal tissues, MDA and GSH levels, SOD, CAT, and GR activity were determined. Also, histopathological and immunohistochemical changes were examined in liver and kidney sections. Urea, creatinine, ALT, AST, and total bilirubin levels increased 5-FU group according to control and prevented to this increases the especially high dose of SLY. 5-FU also causes histopathological and immunohistochemical changes such as degeneration, necrosis, hyperemia, DNA damage, and IL-6 increase in kidney and liver tissue. High doses of SLY prevented these changes caused by 5-FU. As a result of this study, it was determined that SLY has hepatoprotective and nephroprotective effects on 5-FU-induced liver and kidney damage in mice.

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Section: Immunohistochemical Ndingsmentioning

confidence: 99%

Investigation of Effects of Silymarin in 5-Fluorouracil Hepatotoxicity and Nephrotoxicity in Mice

Şengül

Gelen

Yıldırım

et al. 2021

Preprint

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“…Antineoplastic chemotherapeutic agents generally have cytotoxic effects on one or more target tissues (5). The main side effects of CYP are renal toxicity (6), hematopoietic depression and hemorrhagic cystitis (7). Two active metabolites of CYP are phosphoramide and acrolein (6).…”

Section: Introductionmentioning

confidence: 99%

“…The main side effects of CYP are renal toxicity (6), hematopoietic depression and hemorrhagic cystitis (7). Two active metabolites of CYP are phosphoramide and acrolein (6). The toxic effect of CYP is related to acrolein which is an active metabolite of it.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of Protective Effects of Naringin on ECG, Cardiac Enzymes, Cardiac Histopathology and 8-OHdG Expression in Cyclophosphamide-Induced Cardiotoxicity in Rats

Kolikpinar¹,

Dağ²,

Tekin³

et al. 2021

Atatürk Üniversitesi Veteriner Bilimleri Dergisi

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“…NA'nın, ratlarda CYP ile indüklenen hepatotoksisite ve nefrotoksisitede koruyucu etkili olduğu (11,15,16), yine benzer şekilde doxorobucin ile indüklenen kardiyotoksisite modelinde de antioksidan savunma sistemini destekleyerek kalp dokusu üzerine de protektif etkilerinin olduğu rapor edilmiştir (17).…”

Section: Introductionunclassified

Siklofosfamidle İndüklenmiş Ratlarda Serbest Radikaller ve Antioksidanlar Üzerine Naringinin Protektif Etkileri

Çelebi¹,

Cengiz²,

Çınar³

et al. 2020

Atatürk Üniversitesi Veteriner Bilimleri Dergisi

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Öz: Bu çalışmada siklofosfamid (CYP) ile uygulanan ratlarda kan ve serum örneklerinde Naringin (NA)'in antioksidanlar ve serbest radikaller üzerine protektif etkilerinin araştırılması amaçlandı. Araştırmamızda yaklaşık 200-250 g ağırlığında, 40 adet erkek erişkin Sprague Dawley rat kullanıldı ve her bir grupta 8 ratın bulunduğu 5 grup oluşturuldu. Kontrol grubuna 10 gün boyunca intra gastrik (i.g.) serum fizyolojik (1 ml) verildi. CYP grubuna 10 gün boyunca i.g. serum fizyolojik verildi ve 10. gün tek doz intra peritonal (i.p.) CYP (200 mg/kg) enjekte edildi. NA50+CYP ve NA100+CYP gruplarına 10 gün boyunca sırasıyla serum fizyolojikte çözdürülmüş 50 ve 100 mg/kg dozunda i.g. NA uygulandı ve NA'nın son enjeksiyondan sonra tek doz CYP (200 mg/kg, i.p.) enjekte edildi. NA100 grubuna ise 10 gün boyunca 100 mg/kg dozunda i.g. NA uygulandı. Deneyin 12. gününde ratlar tiopental sodyum (20 mg/kg) ile anestezi altına alınarak intra kardiyak kan örnekleri alındı ve dekapite edildiler. Ratlardan elde edilen kan ve serum örneklerinde Total Antioksidan Durumu (TAS), Total Oksidan Durumu (TOS), Oksidatif stres indeksi (OSİ) ve 8-Hydroxydeoxyguanosine (8-OHdG) parametreleri analiz edildi. CYP'nin ratlarda oksidatif stresi artırdığı, antioksidanları baskıladığı ve DNA hasarına yol açtığı tespit edildi. NA'nın farklı dozlarının, CYP'nin sebep olduğu oksidatif stresi baskıladığı, antioksidan miktarını artırdığı ve DNA hasarını önlediği belirlendi.

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Ratlarda Cyclophosphamide ile İndüklenen Nefrotoksisitede Bazı Hematolojik Parametreler ve Böbreğin Histopatolojisi Üzerine Naringinin Protektif Etkileri

Cited by 4 publications

References 32 publications

Investigation of Effects of Silymarin in 5-Fluorouracil Hepatotoxicity and Nephrotoxicity in Mice

Investigation of Effects of Silymarin in 5-Fluorouracil Hepatotoxicity and Nephrotoxicity in Mice

Investigation of Protective Effects of Naringin on ECG, Cardiac Enzymes, Cardiac Histopathology and 8-OHdG Expression in Cyclophosphamide-Induced Cardiotoxicity in Rats

Siklofosfamidle İndüklenmiş Ratlarda Serbest Radikaller ve Antioksidanlar Üzerine Naringinin Protektif Etkileri

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