Rats’ umbilical-cord mesenchymal stem cells ameliorate mast cells and Hsp70 on ovalbumin-induced allergic rhinitis rats

Restimulia, Lia; Munir, Delfitri; Putra, Agung; Madiadipoera, Teti; Farhat, Farhat; Sembiring, Rosita Juwita; Ichwan, Muhammad; Amalina, Nur Dina

doi:10.17392/1421-21

Cited by 6 publications

(1 citation statement)

References 4 publications

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“…To evaluate whether the therapeutic efficacy of ADSC-EVs administration surpasses ADSC administration in AR mouse model treatment, we conducted a comprehensive search on PubMed and Web of Science. Our analysis included 17 articles that utilized the same administration method as our study (8,(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60). In these 17 studies, various types of MSCs such as ADSCs, umbilical cord MSCs (UC-MSCs), BMSCs, tonsil MSCs (T-MSCs), human deciduous tooth MSCs (DT-MSCs), and nasal mucosa MSCs (NM-MSCs) were administered via different dosages and administration methods (Supporting information: Table 1).…”

Section: Similar Therapeutic Effects Were Achieved Using a Lower Adsc...mentioning

confidence: 99%

Extracellular vesicles from adipose stem cells ameliorate allergic rhinitis in mice by immunomodulatory

Yang,

Pan,

Zhang

et al. 2023

Front. Immunol.

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BackgroundHuman adipose tissue-derived stem cells (hADSCs) exert potent immunosuppressive effects in the allogeneic transplantation treatment. In mouse model of allergic rhinitis (AR), ADSCs partially ameliorated AR. However, no study has evaluated the potential therapeutic effects of hADSC-derived extracellular vesicles (hADSC-EVs) on AR.MethodsFemale BALB/c mice were sensitized and challenged with ovalbumin (OVA) to induce AR. One day after the last nasal drop, each group received phosphate buffered saline (PBS) or hADSC-EVs treatment. Associated symptoms and biological changes were then assessed.ResultshADSC-EV treatment significantly alleviated nasal symptoms, and reduced inflammatory infiltration. Serum levels of OVA-specific IgE, interleukin (IL)-4 and interferon (IFN)-γ were all significantly reduced. The mRNA levels of IL-4 and IFN-γ in the spleen also changed accordingly. The T helper (Th)1/Th2 cell ratio increased. The treatment efficacy index of hADSC-EV was higher than that of all human-derived MSCs in published reports on MSC treatment of AR. ADSC-EVs exhibited a greater therapeutic index in most measures when compared to our previous treatment involving ADSCs.ConclusionThese results demonstrated that hADSC-EVs could ameliorate the symptoms of AR by modulating cytokine secretion and Th1/Th2 cell balance. hADSC-EVs could potentially be a viable therapeutic strategy for AR. Further animal studies are needed to elucidate the underlying mechanisms and to optimize potential clinical protocols.

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Section: Similar Therapeutic Effects Were Achieved Using a Lower Adsc...mentioning

confidence: 99%

Extracellular vesicles from adipose stem cells ameliorate allergic rhinitis in mice by immunomodulatory

Yang,

Pan,

Zhang

et al. 2023

Front. Immunol.

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Immunomodulatory properties of mesenchymal stem cells: A potential therapeutic strategy for allergic rhinitis

Wang

Zhao

Zhang

2023

Allergy

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Allergic rhinitis (AR) is a common inflammatory disorder in the nasal mucosa caused by a hyperresponse of the immune system to allergens. The clinical symptoms of AR include sneezing, nasal discharge, itching, and congestion, which have a great impact on health-related quality of life. Since the 1960s, the global prevalence of AR has steadily increased. 1 Currently, the estimated prevalence of AR is 5%-15% in children and 10%-40% in adults. 2,3 The prevalence of allergen-specific immunoglobulin E (IgE) (to any allergen) has been estimated to exceed 50% of the population in Westernised countries. 1 Currently, pharmacotherapy is the cornerstone intervention for AR. However, while this method can control symptoms, it cannot reverse the state of immune imbalance of AR. Moreover, guidelinedirected pharmacotherapy is ineffective for up to 20% of people with AR. 4 Therefore, new and effective treatments are required.

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Red algae extract suppresses caspase-3 gene expression and induces catalase antioxidant enzyme in testicles of rats induced by boric acid

et al. 2022

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Aim To determine the effect of red algae extract on the gene expression of catalase and caspase-3 in testicules of rats induced by boric acid (BA). Methods This is experimental research with post-test control group design. Twenty four healthy male Wistar rats were divided into four treatment groups: a healthy group, negative control group, two treatment groups with red algae extract 400mg/kgBW/day (T1) and red algae extract 800mg/kgBW/day (T2). Each group was treated with BA 500mg/kgBW/day for 14 days, whereas the healthy group did not receive BA. In the treatment groups T1 and T2 were given red algae extract for 14 days. On day 15 all treatment groups were terminated and catalase and caspase-3 gene expression were analysed using qRT-PCR. Results In the healthy group, the expression of the catalase gene was 1.39&plusmn;0.67 and the expression of the caspase-3 gene was 1.06&plusmn;0.17. In the negative control group, there was a significant decrease in catalase gene expression, 0.68&plusmn;0.27 (p&lt;0.05), and a significant increase in caspase-3 gene expression, 5.71&plusmn;2.47 (p&lt;0.05). Treatment groups T1 and T2 showed a significant increase in catalase gene expression, 2.67&plusmn;0.69; and 2.85&plusmn;0.64, respectively (p&lt;0.05) and caspase-3, 3.96&plusmn;1,16 and 1.89&plusmn;0.84, respectively, compared to the control group. Conclusion The administration of red algae extract had a significant effect on increasing the expression of the catalase gene and decreasing the expression of the caspase-3 gene. This suggests that red algae extract has the potential to be developed as a protective agent against exposure to the effects of BA.

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Rats’ umbilical-cord mesenchymal stem cells ameliorate mast cells and Hsp70 on ovalbumin-induced allergic rhinitis rats

Cited by 6 publications

References 4 publications

Extracellular vesicles from adipose stem cells ameliorate allergic rhinitis in mice by immunomodulatory

Extracellular vesicles from adipose stem cells ameliorate allergic rhinitis in mice by immunomodulatory

Immunomodulatory properties of mesenchymal stem cells: A potential therapeutic strategy for allergic rhinitis

Red algae extract suppresses caspase-3 gene expression and induces catalase antioxidant enzyme in testicles of rats induced by boric acid

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