1972
DOI: 10.1254/jjp.22.635
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Re-Examination of Centrally-Induced Cough in Cats Using a Micro-Stimulation Technique

Abstract: The results indicate that the area, in which the cough-like response is produced by electrical stimulation, is confined distinctly to a certain anatomical structure of the me dulla, i.e., the nucleus tractus solitarius. METHODSTwenty cats, weighing 2.5-3.5 kg, were used. These were anesthetized with ether under open drop method and fixed with the aid of a stereotaxic instrument. An occipital crani otomy was performed to expose the cerebellum, and portions of the cerebellum covering the medulla were removed by … Show more

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Cited by 17 publications
(6 citation statements)
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“…34 Electrical stimulation studies of different areas in the medulla suggest that the cough center is diffusely located. [35][36][37][38] Opiates universally inhibit the cough reflex when given centrally. Their effects are blocked by naloxone, suggesting the presence of a u receptor.…”
Section: Anatomy Of the Cough Reflexmentioning
confidence: 99%
“…34 Electrical stimulation studies of different areas in the medulla suggest that the cough center is diffusely located. [35][36][37][38] Opiates universally inhibit the cough reflex when given centrally. Their effects are blocked by naloxone, suggesting the presence of a u receptor.…”
Section: Anatomy Of the Cough Reflexmentioning
confidence: 99%
“…Within the scope of a larger physiological investigation dealing with the role of caudal NTS neurons in swallowing neurogenesis and respiratory reflexes (Jean, 1972(Jean, , 1990Kessler and Jean, 1985;Tell and Jean, 1991;Jean et al, 1994), we examined the synaptic organization of the rat's interstitial subdivision (iNTS) and its laryngeal afferents. We were particularly interested in this subdivision because it constitutes the principal site of projection of laryngeal af€erents (Kalia and Mesulam, 1980b;Hamilton and Norgren, 1984;Altschuler et al, 1989) involved in the initiation of swallowing and of several respiratory reflexes such as coughing (Doty, 1951;Jean, 1972;Miller, 1972;Mori and Sakai, 1972;Gr6lot and Milano, 1991). Some of these results have appeared in abstract form (Mrini and Jean, 1993).…”
Section: Bcmentioning
confidence: 99%
“…Electrical stimulation of the superior laryngeal nerve (SLN) is a useful method for studying these reflexes in animal experiments. A brief pulse train (100 Hz) applied to the SLN elicits inspiration-toexpiration phase switching (Iscoe, Feldman & Cohen, 1979), whereas continuous pulses at a lower frequency (3-30 Hz) evoke swallowing (Doty, 1951;Miller & Loizzi, 1974;Amri, Car & Jean, 1984) and coughing (Mori & Sakai, 1972;Iscoe & Grelot, 1992), as well as prolonged apnoea (Remmers, Richter, Ballantyne, Rainton & Klein, 1986). Recent studies have introduced methods to evoke fictive coughing (Grelot & Milano, 1991;Bolser, 1991), fictive swallowing (Nishino, Honda, Kohchi, Shirahata & Yonezawa, 1985;Dick, Oku, Romaniuk & Cherniack, 1993), or both (Grelot, Milano, Portillo, Miller & Bianchi, 1992) in paralysed and artificially ventilated animals.…”
mentioning
confidence: 99%