Reaction of benzalacetophenone with methylmagnesium iodide. Novel Grignard reaction

Dichloro[(−)-sparteine-N,N']copper(II)

“…Metal complexes of sparteine alkaloids (Mason & Peacock, 1973) are useful reagents in organic synthesis. The bulky chiral sparteine ligand creates asymmetry around the metal atom, and can induce varying degrees of enantiomeric purity when used in certain addition reactions (Beak et al, 1996;Kretchmer, 1972). The exact geometry of the complexes, and in particular the steric accessibility to the metal center, is the key to their successful application.…”

Synthesis of a Novel Carbon Ring Compound, 2, 4-Dibenzoyl-1, 3, 5-triphenylcyclohexanol, from Acetophenone and Benzaldehyde under Phase Transfer Conditions

“…Thus, the product could be a mixture of enatiomers exclusive of diastereomers. This seems to have been reflected in the relatively sharp melting points as well as in the unexpectedly simple NMR spectra of (4), (5), and (6). To check the validity of the above surmise, X-ray crystallographic investigation of the products will be indispensable.…”

Dichloro[(6R,7S,8S,14S)-(–)-sparteine-κ2N,N′]mercury(II)

“…(À)-Sparteine (spar), a naturally occurring tertiary diamine, has been intensively utilized in medicinal chemistry (Cady et al, 1977), in the asymmetric synthesis of chiral compounds (Beak et al, 1996;Kretchmer, 1972;Mason & Peacock, 1973) and in the preparation of a model compound for the type I copper(II) site in metalloproteins (Kim et al, 2001). The structures of several metal(II) sparteine dichloride complexes of the type [MX 2 (spar)] (M = Fe II , Co II , Ni II , Cu II or Zn II , and X = Cl À or Br À ) have been reported, and the metal moieties in these compounds are known to have a distorted tetrahedral geometry (Kang, Choi et al, 2004;Kang, Lee et al 2004;Kuroda & Mason, 1979;Lee et al, 2002Lee et al, , 2003Lopez et al, 1998;Lorber et al, 2002).…”