Reaction of Nucleic Acids With Metals

Kriss, E.E.; Yatsimirskii, K. B.

doi:10.1070/rc1966v035n02abeh001436

Cited by 14 publications

(6 citation statements)

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“…There is evidence on mutagenic properties of Ag + -the formation of metal complexes of nucleic acids with Ag + ions and other heavy metals as gold, whereby is interrupted the spatial structure of the DNA and the ability of bacteria to divide [25]. Also it is assumed that one of the causes of antimicrobial action of Ag + is the inhibition by Ag + ions the transmembrane transport of Na + and Ca 2+ ions [26].…”

Section: Resultsmentioning

confidence: 99%

Scientific Research Center of Medical Biophysics (SRC MB), Bulgaria

Ignatov¹,

Mosin²

2015

Nanotechnology Research and Practice

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In this review article are studied the methods for preparation of micro dispersed colloid silver nanoparticles and scopes of their practical application in nano-industry, bionanotechnology, medicine and allied industries, including water processing and water purification techniques. The mechanisms of bactericidal influence of colloid silver on a microbial cell are discussed from the point of view of absorptive, electrostatic, enzyme and mutagen theories. Silver exerts both bactericidal and bacteriostatic effect against more than 500 species of microorganisms. The effect of bacterial destruction by silver is 1500 times more than the same concentration of phenol and 3,5 times more than the action of mercuric chloride. It is demonstrated that effects of colloid silver are defined by the concentration, the sizes of micro dispersed nanoparticles and their stability in water solutions. The silver nanoparticles in their turn may be prepared by using various physicochemical, biochemical and biotechnological methods.

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Section: Resultsmentioning

confidence: 99%

Scientific Research Center of Medical Biophysics (SRC MB), Bulgaria

Ignatov¹,

Mosin²

2015

Nanotechnology Research and Practice

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“…[4,8]. The generation of reactive oxygen species, in turn, leads to cell wall destruction and dis ruption of the structure of DNA and proteins [9].…”

Section: Introductionmentioning

confidence: 99%

The effects of silver nitrate on the phase state of model multibilayer membranes

et al. 2015

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To investigate the effects of silver nitrate (AgNO 3 ) on model lipid membranes, we studied multi bilayer membranes based on L α dipalmitoylphosphatidylcholine (DPPC) and AgNO 3 aqueous solutions in a wide concentration range (up to 30 wt %) using differential scanning calorimetry. It was shown that the pres ence of AgNO 3 leads to both an increase in the main phase transition temperature (T m ) of DPPC multibilay ers and the appearance of an additional phase transition peak ( ), suggesting an increase in both the density and heterogeneity of the lipid bilayer. Since the effect of nitrate ions ( ) was of the opposite nature (bilayer fluidizing), the integral effect of AgNO 3 can be explained solely by the effect of silver ions (Ag + ). With increasing AgNO 3 concentration, the tendency to opposite changes in T m and peak intensity was observed, so that at approximately 26 wt % AgNO 3 the initial peak (T m ) disappeared. In the range of thera peutic Ag + concentrations (up to 2 wt %), no significant changes in the phase state of model membranes were observed. This can be one of the causes of the absence of a damaging effect of silver containing drugs on the host cells against the background of a pronounced bactericidal effect.

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“…La determination des constantes de stabilite des complexes a ete effectuee principalement par potentiometrie (5,6), par spectrophotometrie (8) et par une methode cinetique indirecte de dosage du cuivre basee sur son action catalytique dans une reaction d'oxydation (9).…”

Section: Introductionunclassified

Etude cinétique des systèmes Cu(II)_•Adénosine et Cu(II)_•D-Ribose

Boivin¹,

Zador²

1972

Can. J. Chem.

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Requ le 27 avril 1972La cinetique de formation et de dissociation des complexes entre le Cu(1I) et I'adenosine a ete etudiee en milieu acide ainsi qu'en milieu basique. En milieu acide, les paramitres cinetiques ont etC obtenus par la methode de relaxation et ils correspondent au complexe forme avec le groupement adenine. En milieu basique seule la dissociation des complexes a pu 2tre Ctudiee par la methode du "flux stoppe", en utilisant I'EDTA ou un acide fort pour dissocier les complexes, formes dans ce cas avec les groupes hydroxyles du ribose. A titre de comparaison, le D-ribose a ete egalement etudie dans ces conditions. Le mecanisme de ces reactions est discute.The kinetics of the formation and dissociation of Cu(l1) complexes of adenosine have been determined in acidic and basic medium. In acidic medium, the complex is formed between the Cu(l1) and the adenine biise and the kinetic parameters have been obtained in this case using a temperature jump method. In basic medium, only the dissociation of the complexes could be studied by a stopped-flow method, by addition of EDTA or strong acid solutions. In these complexes, Cu(ll) is bridged with ribose hydroxyls. Finally, D-ribose has also been studied for comparison in the same conditions. The mechanism of these reactions is discussed.

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Reaction of Nucleic Acids With Metals

Cited by 14 publications

References 1 publication

Scientific Research Center of Medical Biophysics (SRC MB), Bulgaria

Scientific Research Center of Medical Biophysics (SRC MB), Bulgaria

The effects of silver nitrate on the phase state of model multibilayer membranes

Etude cinétique des systèmes Cu(II)_•Adénosine et Cu(II)_•D-Ribose

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Reaction of Nucleic Acids With Metals

Cited by 14 publications

References 1 publication

Scientific Research Center of Medical Biophysics (SRC MB), Bulgaria

Scientific Research Center of Medical Biophysics (SRC MB), Bulgaria

The effects of silver nitrate on the phase state of model multibilayer membranes

Etude cinétique des systèmes Cu(II)•Adénosine et Cu(II)•D-Ribose

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Etude cinétique des systèmes Cu(II)_•Adénosine et Cu(II)_•D-Ribose