Reactive eccrine syringofibroadenomatosis presenting as bilateral plantar hyperkeratosis

Singh, Nidhi; Chandrashekar, Laxmisha; Pragasam, Shakthi; Thappa, Devinder Mohan; Badhe, Bhawana Ashok; Sylvia, Mary Theresa

doi:10.4103/0019-5154.160497

Cited by 6 publications

(5 citation statements)

References 19 publications

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“…Reactive ESFA is related to tissue regeneration and remodeling after damage, such as trauma and burns 4 . Singh et al 5 reported ESFA that occurred in the sole, a site under constant pressure in a patient with diabetes mellitus. In this case, the skin lesion showed a characteristic verrucous growth pattern, which was thought to be due to the pressure effect of weight-bearing of the sole.…”

Section: Discussionmentioning

confidence: 99%

A Case of Eccrine Syringofibroadenoma Related to Senile Gluteal Dermatosis

Kim,

Ahn,

Shin

2023

Ann Dermatol

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Eccrine syringofibroadenoma (ESFA) is a tumor of eccrine ductal differentiation. ESFA is a rare disease, with only approximately 80 cases reported worldwide. ESFA can be classified into five subtypes. Senile gluteal dermatosis (SGD) was first reported in Japan in 1979. It is a relatively common geriatric dermatosis in East Asia, and characterized by hyperkeratotic lichenified skin lesions in the gluteal region. An 86-year-old woman presented with a solitary recurrent dark brown plaque in the sacral area. There was a hyperkeratotic lichenified brownish patch around the plaque, which was clinically considered SGD. Histopathological examination of biopsy specimen revealed thin anastomosing reticulated strands of basaloid cuboidal cells. The tumor extends from the basal layer of the epidermis to the dermis. These findings are consistent with those of ESFA. The patient was treated with total excision of the skin lesion. Reactive ESFA is related to tissue regeneration and remodeling after damage, such as trauma and burns. There is no literature reporting ESFA related to SGD so far, but there have been few reports of cases occurring in soles or buttocks, which are constantly under pressure. This is the first report on reactive ESFA related to SGD, and further research is needed to reveal the pathogenic mechanism.

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Section: Discussionmentioning

confidence: 99%

A Case of Eccrine Syringofibroadenoma Related to Senile Gluteal Dermatosis

Kim,

Ahn,

Shin

2023

Ann Dermatol

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“…19 Overall, the clinical course of reactive ESFA is benign, and the risk of malignant transformation is low. 9 Recurrences and metastasis have not been reported. If an ESFA lesion increases in size fast, becomes painful, bleeds, ulcerates, or crusts, it is more likely to be associated with malignancy.…”

Section: Discussionmentioning

confidence: 99%

“…Less than 40 cases of reactive ESFA have been reported in the English literature. Few cases reported the association of ESFA with benign entities that are related to repeated damage to the eccrine skin structures by chronic inflammation such as diabetic polyneuropathy, 8 palmoplantar lichen planus, 7 bilateral plantar hyperkeratosis, 9 leprosy, 10 venous stasis, 5 and burn scar. 11…”

Section: Introductionmentioning

confidence: 99%

Reactive Eccrine Syringofibroadenoma (ESFA) in Association With a Merkel Cell Carcinoma Excision Scar

Salah

Czelusta

Sánchez³

2022

The American Journal of Dermatopathology

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:Eccrine syringofibroadenoma (ESFA) is a rare benign skin adnexal lesion of the acrosyringium of eccrine sweat ducts. Reactive ESFA, a subtype of ESFA, is usually associated with non-neoplastic cutaneous dermatoses or neoplastic skin tumors. Clinically, the lesions can be solitary or multiple, pink, or skin-colored coalescing papules or nodules of variable sizes. Histopathologically, this tumor is composed of numerous anastomosing cords of monomorphic cuboidal epithelial cells with eccrine duct formation. The association of reactive ESFA with benign conditions, such as psoriasis, diabetic polyneuropathy, scars, and leprosy, has been reported. However, the association of reactive ESFA with malignant tumors is extremely rare, with very few cases reported in the literature. We present a case of a 72-year-old woman who developed reactive ESFA associated with Merkel cell carcinoma excision scar. The ESFA tumors developed in the area of the surgical graft 10 months after the Merkel cell carcinoma had been excised. New ESFA tumors have continued to appear in the scar on a yearly basis while, so far, has been no recurrence of the original tumor. However, the presence of new tumor growths in the area suggested the possibility of recurrence of the Merkel cell carcinoma. That possibility was enhanced by the fact that PET scans revealed hypermetabolic activity in the ESFA papules.

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“…It was first classified into the following four types by Starink: solitary, multiple ESFA associated with hidrotic ED-like Schopf–Schulz–Passarge syndrome (eyelid cysts, hypotrichosis, hypodontia, nail hypoplasia) or Clouston syndrome (palmoplantar keratoderma, patchy alopecia, nail dystrophy), multiple ESFA without associated cutaneous findings, and nonfamilial unilateral linear ESFA. [ 1 2 3 ] In 1997, the fifth type was recognized as reactive ESFA by French as a ductal hyperplastic or hamartomatous process initiated by repeated damage to the eccrine structures by chronic inflammatory or neoplastic dermatoses such as diabetic foot ulcer, leprous neuropathy, venous stasis or insufficiency, burn scar, BP, EB, naevus sebaceous, stoma of ileostomy, palmoplantar erosive LP, trauma, chronic plaque type psoriasis, epithelioid haemangioendothelioma, and squamous cell carcinoma. [ 4 5 6 ] Reactive ESFA is usually single and acrally located, but if multiple sites are involved, it is termed as “eccrine syringofibroadenomatosis.” Apart from these five types, another clear cell variant was also reported by Hu et al .…”

Section: Discussionmentioning

confidence: 99%

A case report of reactive solitary eccrine syringofibroadenoma

Tiwary

Firdous

Mishra

et al. 2017

Indian Dermatol Online J

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Eccrine syringofibroadenoma is a very rare benign tumour of acrosyringium of eccrine sweat duct. Based on the evidences of known etiological factors, two forms have been proposed; reactive and nonreactive. Reactive forms are rarer, and on even rarer occasions, trauma complicated by secondary nonspecific infections may lead to the development of reactive eccrine syringofibroadenoma, as in our case. Here, we are documenting a case of reactive solitary eccrine syringofibroadenoma in a 65-year-old male presenting with coalescing, firm, pinkish, verrucous nodules and painful deep ulceration on the right sole preceded by trauma and secondary infection. Histopathologic revelation of distinctive microscopic findings confirmed the diagnosis in our case.

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Reactive eccrine syringofibroadenomatosis presenting as bilateral plantar hyperkeratosis

Cited by 6 publications

References 19 publications

A Case of Eccrine Syringofibroadenoma Related to Senile Gluteal Dermatosis

A Case of Eccrine Syringofibroadenoma Related to Senile Gluteal Dermatosis

Reactive Eccrine Syringofibroadenoma (ESFA) in Association With a Merkel Cell Carcinoma Excision Scar

A case report of reactive solitary eccrine syringofibroadenoma

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