Reactive oral lesions associated with dental implants. A systematic review

Atarbashi-Moghadam, Fazele; Atarbashi-Moghadam, Saede; Namdari, Mahshid; Shahrabi‐Farahani, Shokoufeh

doi:10.1111/jicd.12342

Cited by 13 publications

(26 citation statements)

References 28 publications

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“…This distribution could be explained by the fact that dental implants are more commonly installed in the mandible of older females. In the present sample, CGCL and peri-implant PGCL occurred more commonly in the mandible of females, in accordance with previous studies (18,22,23). Both conventional and peri-implant PGCL affected older patients in comparison with CGCL, also in accordance with the literature (4,5,18).…”

Section: Discussionsupporting

confidence: 93%

Peri-implant peripheral giant cell lesions: report of 13 new cases and comparative histological and immunohistochemical analysis with peripheral and central giant cell lesions

Morais¹,

Soares²,

Aguirre‐Urízar³

et al. 2019

Med Oral

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Background Few cases or peri-implant peripheral giant cell lesions (PGCL) have been reported in the literature. The aim of this study was to report 13 new cases of peri-implant PGCL and compare the expression of smooth muscle actin, Bcl-2 protein, GLUT-1, CD68, osteoprotegerin, receptor activator of nuclear factor kappa-B, Ki-67 and CD34 in these cases with PGCL and central giant cell lesions (CGCL). Material and Methods Clinical data were retrieved from the laboratory records and histological analysis was performed using HE-stained slides. Immunohistochemical reactions for the above mentioned antibodies were performed and digitally scored. Results Peri-implant PGCL mostly affected the posterior mandible of adult females. CD68 and Bcl-2 expressions were higher in conventional PGCL and CGCL than in peri-implant PGCL (p=0.033 for CD68 and p<.0001 for Bcl-2). Microvessel density was higher in conventional peripheral than in central and peri-implant PGCL (p=0.002). Proliferative index of the mononuclear cells showed no statistically significant differences comparing the three groups but it was higher in peri-implant PGCL. Conclusions The current study demonstrated that peri-implant PGCL is more common in the posterior mandible of adult females. There were some differences in microvessel density, proliferative activity and expression of CD68 and Bcl-2 among conventional PGCL, peri-implant and CGCL. Further studies are encouraged to better understand these early findings. Key words:Giant cell lesion, giant cell granuloma, peripheral, dental implants, immunohistochemistry.

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Section: Discussionsupporting

confidence: 93%

Peri-implant peripheral giant cell lesions: report of 13 new cases and comparative histological and immunohistochemical analysis with peripheral and central giant cell lesions

Morais¹,

Soares²,

Aguirre‐Urízar³

et al. 2019

Med Oral

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“…One implant showed gingival hyperplasia due to lack of attached gingiva. Poor oral hygiene and lack of regular attendance at recall visits were reported as important factors in occurrence of peri-implant diseases 26 - 28 . These results emphasize that oral hygiene and compliance with follow-up programs have important roles in PLS patient implant success.…”

Section: Discussionmentioning

confidence: 99%

Oral rehabilitation of Papillon–Lefèvre syndrome patients by dental implants: a systematic review

Atarbashi-Moghadam

Kazemifard

et al. 2020

JKAOMS

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Objectives: Papillon-Lefèvre syndrome (PLS) is a rare autosomal recessive disorder. These patients lose their teeth at a young age and are in need of prosthetic rehabilitation. The aim of this systematic review was to assess the success of dental implant placement in these patients. Materials and Methods: An electronic search was performed in PubMed Central, Scopus, and Web of Science using the keyword "Papillon-Lefèvre syndrome" AND "dental implant" OR "prosthodontics". Articles reporting implant placement in patients with PLS until July 2019 were included. Results: Assessment of the included 11 articles reporting 15 cases showed 136 implant placements in these patients. Implant failure occurred in 3 patients (20 implants). The peri-implantitis and failure rate was higher in the maxilla. Meta-analysis showed the probability of failure to be 7% (95% confidence interval [CI] 0%-31%) for maxillary implants and 2% (95% CI 0%-9%) for mandibular implants. The follow-up time ranged between 1 and 20 years. Healing after bone graft and implant placement in these patients was uneventful. Conclusion: Dental implants may be a viable treatment option for PLS patients. Implantation can help preserve alveolar bone if the patients' immunological and growing conditions are well-considered and proper oral hygiene and compliance with the maintenance program are continued.

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“…The replacement of missing teeth with dental implants has a high success rate, but it is still a technique which involves risks and requires good evaluation and planning to minimize failures [1,2]. However, the increasing number of dental implants used leads the dentist to encounter biological and technical complications [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…The appearance of so-called peri-implant reactive lesions is another complication that must be taken into consideration. Despite its lower incidence, its presence could imply the need for explantation [2,3,8]. Reactive lesions are characterized by excessive proliferation of connective tissue in response to chronic irritation [9].…”

Section: Introductionmentioning

confidence: 99%

An analysis of the prevalence of peripheral giant cell granuloma and pyogenic granuloma in relation to a dental implant

et al. 2021

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Background The aim of the present investigation was to evaluate the literature recurrence of peripheral giant cell granuloma and pyogenic granuloma associated with dental implants. It’s important to know the characteristics present in these lesions and possible effects on the prognosis of dental implants. Methods An electronic search without time restrictions was done in the databases: PubMed/Medline. With the keywords "Granuloma" OR "Granuloma, Giant Cell" OR "peripheral giant cell" OR "Granuloma, Pyogenic” AND "Dental implants" OR "Oral implants”. Results After applying the inclusion and exclusion criteria, a total of 20 articles were included, which reported 32 lesions (10 pyogenic granulomas, 21 peripheral giant cell granulomas and one peripheral giant cell granuloma combined with peripheral ossifying fibroma, all associated with implants). According to our review, these lesions are more frequent in males and in the posterior region of the mandible. Both excision and curettage of the lesion, compared to only excision, presented similar recurrences (40%). Explantation of the implant was performed in 41% of cases without additional recurrences. The results are not statistically significant when comparing one lesion to the other in terms of explantation (p = 0.97), recurrence (p = 0.57) or bone loss (p = 0.67). Conclusions The main therapeutic approach is tissue excision. The lesions show a high recurrence rate (34.4%), which often requires explantation of the associated implant. This recurrence rate is not affected by curettage after excision.

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Reactive oral lesions associated with dental implants. A systematic review

Cited by 13 publications

References 28 publications

Peri-implant peripheral giant cell lesions: report of 13 new cases and comparative histological and immunohistochemical analysis with peripheral and central giant cell lesions

Peri-implant peripheral giant cell lesions: report of 13 new cases and comparative histological and immunohistochemical analysis with peripheral and central giant cell lesions

Oral rehabilitation of Papillon–Lefèvre syndrome patients by dental implants: a systematic review

An analysis of the prevalence of peripheral giant cell granuloma and pyogenic granuloma in relation to a dental implant

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