Reactive oxygen species in pulmonary inflammation by ambient particulates

Tao, Florence; González-Flecha, Beatriz; Kobzik, Lester

doi:10.1016/s0891-5849(03)00280-6

Cited by 350 publications

(242 citation statements)

References 84 publications

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“…Following the discovery of the potential importance of isoprene SOA in generating ROS, Lin et al (2016) showed that isoprene SOA formed from the reactive uptake of epoxides alters levels of oxidative stress-associated genes, including COX-2 in human lung cells. Oxidative stress caused by ROS plays a major role in lung inflammation and the induction of oxidative stress can lead to IL-8 expression (Tao et al, 2003;Yan et al, 2015). Specifically, oxidants can activate the transcription factor NF-κB, which regulates a wide range of inflammatory genes including IL-8 and COX-2 (Barnes and Adcock, 1997; Schreck et al, 1992).…”

Section: Biological Implicationsmentioning

confidence: 99%

In vitro exposure to isoprene-derived secondary organic aerosol by direct deposition and its effects on COX-2 and IL-8 gene expression

et al. 2016

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Abstract. Atmospheric oxidation of isoprene, the most abundant non-methane hydrocarbon emitted into Earth's atmosphere primarily from terrestrial vegetation, is now recognized as a major contributor to the global secondary organic aerosol (SOA) burden. Anthropogenic pollutants significantly enhance isoprene SOA formation through acidcatalyzed heterogeneous chemistry of epoxide products. Since isoprene SOA formation as a source of fine aerosol is a relatively recent discovery, research is lacking on evaluating its potential adverse effects on human health. The objective of this study was to examine the effect of isoprenederived SOA on inflammation-associated gene expression in human lung cells using a direct deposition exposure method. We assessed altered expression of inflammationrelated genes in human bronchial epithelial cells (BEAS-2B) exposed to isoprene-derived SOA generated in an outdoor chamber facility. Measurements of gene expression of known inflammatory biomarkers interleukin 8 (IL-8) and cyclooxygenase 2 (COX-2) in exposed cells, together with complementary chemical measurements, showed that a dose of 0.067 µg cm −2 of SOA from isoprene photooxidation leads to statistically significant increases in IL-8 and COX-2 mRNA levels. Resuspension exposures using aerosol filter extracts corroborated these findings, supporting the conclusion that isoprene-derived SOA constituents induce the observed changes in mRNA levels. The present study is an attempt to examine the early biological responses of isoprene SOA exposure in human lung cells.

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Section: Biological Implicationsmentioning

confidence: 99%

In vitro exposure to isoprene-derived secondary organic aerosol by direct deposition and its effects on COX-2 and IL-8 gene expression

et al. 2016

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“…The methanolic extract of M. vulgare has shown incredible in vitro antioxidant activity and free radical scavenging property due to the presence of diterpenes, flavonoids, and phenols. 16 Reactive nitrogen species (RNS) 17 in addition to reactive oxygen species (ROS) 18 have important role in oxidative stress conditions, especially inflammation. In recent years, the protective effects of antioxidants have been proved in inflammation 19 and provide a new insight in order to reduce…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and Anti-Inflammatory Effect of Marrubium vulgare L. Methanol Extract on Carrageenan-Induced Paw Inflammation in Rats

Fathiazad¹,

Rameshrad²,

Asghari³

et al. 2017

Pharm Sci

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“…Fine metal-containing particles pose known inhalation health risks [13][14][15], based on studies concerned with occupational health and safety in the metals industry [16,17] or the health effects of atmospheric fine and ultrafine particulates [18][19][20]. Based on these studies, and on the limited available literature on nanotube toxicity [21][22][23][24][25][26][27][28], there is a real concern that CNT-metals will trigger similar mechanisms of toxicity and carcinogenicity.…”

Section: Introductionmentioning

confidence: 99%

Targeted removal of bioavailable metal as a detoxification strategy for carbon nanotubes

Liu

Guo

Morris

et al. 2008

Carbon

124

110

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There is substantial evidence for toxicity and/or carcinogenicity upon inhalation of pure transition metals in fine particulate form. Carbon nanotube catalyst residues may trigger similar metal-mediated toxicity, but only if the metal is bioavailable and not fully encapsulated within fluid-protective carbon shells. Recent studies have documented the presence of bioavailable iron and nickel in a variety of commercial as-produced and vendor "purified" nanotubes, and the present article examines techniques to avoid or remove this bioavailable metal. First, data are presented on the mechanisms potentially responsible for free metal in "purified" samples, including kinetic limitations during metal dissolution, the re-deposition or adsorption of metal on nanotube outer surfaces, and carbon shell damage during last-step oxidation or one-pot purification. Optimized acid treatment protocols are presented for targeting the free metal, considering the effects of acid strength, composition, time, and conditions for post-treatment water washing. Finally, after optimized acid treatment, it is shown that the remaining, non-bioavailable (encapsulated) metal persists in a stable and biologically unavailable form up to two months in an in vitro biopersistence assay, suggesting that simple removal of bioavailable (free) metal is a promising strategy for reducing nanotube health risks.

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Reactive oxygen species in pulmonary inflammation by ambient particulates

Cited by 350 publications

References 84 publications

In vitro exposure to isoprene-derived secondary organic aerosol by direct deposition and its effects on <i>COX-2</i> and <i>IL-8</i> gene expression

In vitro exposure to isoprene-derived secondary organic aerosol by direct deposition and its effects on <i>COX-2</i> and <i>IL-8</i> gene expression

Phytochemical Screening and Anti-Inflammatory Effect of Marrubium vulgare L. Methanol Extract on Carrageenan-Induced Paw Inflammation in Rats

Targeted removal of bioavailable metal as a detoxification strategy for carbon nanotubes

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Reactive oxygen species in pulmonary inflammation by ambient particulates

Cited by 350 publications

References 84 publications

In vitro exposure to isoprene-derived secondary organic aerosol by direct deposition and its effects on &lt;i&gt;COX-2&lt;/i&gt; and &lt;i&gt;IL-8&lt;/i&gt; gene expression

In vitro exposure to isoprene-derived secondary organic aerosol by direct deposition and its effects on &lt;i&gt;COX-2&lt;/i&gt; and &lt;i&gt;IL-8&lt;/i&gt; gene expression

Phytochemical Screening and Anti-Inflammatory Effect of Marrubium vulgare L. Methanol Extract on Carrageenan-Induced Paw Inflammation in Rats

Targeted removal of bioavailable metal as a detoxification strategy for carbon nanotubes

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In vitro exposure to isoprene-derived secondary organic aerosol by direct deposition and its effects on <i>COX-2</i> and <i>IL-8</i> gene expression

In vitro exposure to isoprene-derived secondary organic aerosol by direct deposition and its effects on <i>COX-2</i> and <i>IL-8</i> gene expression