Reagent-less amperometric glucose biosensor based on a graphite rod electrode layer-by-layer modified with 1,10-phenanthroline-5,6-dione and glucose oxidase

Kausaitė-Minkstimienė, Asta; Simanaityte, Ruta; Ramanavičienė, Almira; Glumbokaitė, Laura

doi:10.1016/j.talanta.2017.04.047

Cited by 18 publications

(7 citation statements)

References 38 publications

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“…However, to introduce the temperature stability to the probe, aptamers can be used (Jarczewska et al 2016). Similarly, enzymes are used if the target molecule can be catalyzed to give electroactive species, for example, glucose oxidase has been used for glucose detection (Kausaite-Minkstimiene et al 2017;Shen et al 2017). These bio-recognition elements immobilized onto the biosensing transducer usually is a modified electrode, where various strategies are employed for the modification including adsorption and covalent modification.…”

Section: Probe Design and Developmentmentioning

confidence: 99%

Fundamentals and commercial aspects of nanobiosensors in point-of-care clinical diagnostics

2018

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Among various problems faced by mankind, health-related concerns are prevailing since long which are commonly found in the form of infectious diseases and different metabolic disorders. The clinical cure and management of such abnormalities are greatly dependent on the availability of their diagnoses. The conventional diagnostics used for such purposes are extremely powerful; however, most of these are limited by time-consuming protocols and require higher volume of test sample, etc. A new evolving technology called "biosensor" in this context shows an enormous potential for an alternative diagnostic device, which constantly compliments the conventional diagnoses. In this review, we have summarized different kinds of biosensors and their fundamental understanding with various state-of-the-art examples. A critical examination of different types of biosensing mechanisms is also reported highlighting the advantages of electrochemical biosensors for its great potentials in next-generation commercially viable modules. In recent years, a number of nanomaterials are extensively used to enhance not only the performance of biosensing mechanism, but also obtain robust, cheap, and fabrication-friendly durable mechanism. Herein, we have summarized the importance of nanomaterials in biosensing mechanism, their syntheses as well as characterization techniques. Subsequently, we have discussed the probe fabrication processes along with various techniques for assessing its analytical performances and potentials for commercial viability.

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Section: Probe Design and Developmentmentioning

confidence: 99%

Fundamentals and commercial aspects of nanobiosensors in point-of-care clinical diagnostics

2018

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“…However, one crucial issue to construct enzyme based systems is anchoring of biomolecules on the electrode surface. A number of relevant literature reported that different materials have been used for enzyme immobilization [3][4][5][6][7]. The charming properties of conjugated polymeric materials led scientists to explore the opportunities of utilizing them in biosensor constructions.…”

Section: Introductionmentioning

confidence: 99%

“…In the following step, GOx-FADH 2 is oxidized by the final electron acceptor, molecular oxygen (O 2 ). During this process, the reduced form -GOx-FADH 2 -is regenerated back into oxidized form -GOx-FAD, and in addition H 2 O 2 is formed [4].…”

Section: Introductionmentioning

confidence: 99%

A thiazolothiazole containing multichromic polymer for glucose detection

Söylemez¹,

Kaya²,

Udum³

et al. 2019

Express Polym. Lett.

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Donor-acceptor (DA) type monomers namely 2,5-di(thiophen-2-yl)thiazolo[5,4-d]thiazole (TTzTh) and 2,5-bis(3methylthiophen-2-yl)thiazolo[5,4-d]thiazole (TTzMTh) were synthesized and their electrochemical and optoelectronic properties were investigated in detail. The spectro-electrochemical analysis showed that the alkyl chain substitution results in a shift in the onset of the π-π* transition towards longer wavelengths. Depending on the donor substituents, the polymers exhibited optical band gaps 1.65 and 1.85 eV for PTTzTh and PTTzMTh, respectively. Electrochromic studies revealed that both polymers are p-dopable and multichromic. Moreover, polymer of TTzTh (PTTzTh) has been used for the development of a glucose biosensor. Glucose oxidase (GOx) was anchored on a graphite electrode which was previously modified with a film of the conjugated polymer, PTTzTh by electropolymerization. Such a sensor showed a wide linear range (0.05-2.0 mM), good sensitivity (36.32 µA/(mM•cm 2) and low limit of detection (LOD) (0.075 mM) under formerly optimized conditions. Moreover, the accuracy of the biosensor was successfully tested using two different beverages to detect glucose. Electrochemical characterizations of the polymers and their biosensor application were investigated for the first time in this work.

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“…More specifically, derivatives of dibenzophenanthrolines are immensely important targets in organic synthesis because of their biological activities, such as anticancer , antibacterial , and antiparasitic properties. In addition to that, some of their derivatives were used as chelating ligands in the manufacture of organic semiconductor materials . As a result, the development of synthetic procedures for the facile dibenzophenanthroline derivatives has been keenly investigated.…”

Section: Introductionmentioning

confidence: 99%

Microwave‐assisted Synthesis of Dihydro Dibenzophenanthroline and Its Derivatives Using a Self‐catalyzed Friedlander Reaction

Chandraprakash

Vandana

Sankaran

et al. 2018

Journal of Heterocyclic Chem

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One‐step microwave‐assisted synthesis of dihydro dibenzophenanthrolines are reported using a self‐catalyzed Friedlander reaction. The reaction is carried out in one step by simple microwave irradiation of 3,4‐dihydroacridin‐1(2H)‐one with 2‐amino‐benzophenone in the presence of acid catalysts with solvent‐free conditions. Thin‐layer chromatography was used to monitor the progress of the reaction; hence, it was observed that the reaction starts slowly and accelerates as it proceeds to ring fusion transformation. Synthesized compounds' isolated yield is enhanced in the absence of solvent systems with Friedlander catalyst under microwave irradiations.

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Reagent-less amperometric glucose biosensor based on a graphite rod electrode layer-by-layer modified with 1,10-phenanthroline-5,6-dione and glucose oxidase

Cited by 18 publications

References 38 publications

Fundamentals and commercial aspects of nanobiosensors in point-of-care clinical diagnostics

Fundamentals and commercial aspects of nanobiosensors in point-of-care clinical diagnostics

A thiazolothiazole containing multichromic polymer for glucose detection

Microwave‐assisted Synthesis of Dihydro Dibenzophenanthroline and Its Derivatives Using a Self‐catalyzed Friedlander Reaction

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