Realization of a multichannel integrated Young interferometer chemical sensor

Ymeti, Aurel; Kanger, Johannes S.; Greve, Jan; Lambeck, Paul; Wijn, Robert Raimond; Heideman, René

doi:10.1364/ao.42.005649

Cited by 97 publications

(65 citation statements)

References 20 publications

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“…Whilst the majority of optical interferometric biosensors have been implemented with optical waveguides [9][10][11], optical fiber based implementation can offer an important addition as the fibers can be fusion-spliced together, leading to an all-fiber configuration. This eliminates the mechanicallyinduced errors often associated with optical alignment in bulk-optic systems and thus is particularly attractive for applications requiring portability such as in-field surveillance of pathogens.…”

Section: Introductionmentioning

confidence: 99%

Interferometric-type optical biosensor based on exposed core microstructured optical fiber

Nguyen

Hill

Warren‐Smith

et al. 2015

Sensors and Actuators B: Chemical

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In all cases accepted manuscripts should:  link to the formal publication via its DOI  bear a CC-BY-NC-ND license -this is easy to do, click here to find out how  if aggregated with other manuscripts, for example in a repository or other site, be shared in alignment with our hosting policy  not be added to or enhanced in any way to appear more like, or to substitute for, the published journal article Abstract: This work presents a novel biosensor using the multimode interference effect in an exposed core microstructured optical fiber (ECF). In this work biotin molecules are immobilized onto the ECF core surface to serve as the capturing probe for streptavidin, the target molecules.Since each distinct guided mode in the ECF interacts with the surrounding medium differently, the interference between any two specific modes will experience a fringe shift (or phase change) upon a change in the refractive index (RI) of the surrounding medium, or a localized RI change on the surface of the ECF core as a result of a biological binding event. In our experiment, the interferometric sensing platform was realized by splicing a section of ECF with lead-in and leadout single mode fibers (SMFs). An interference pattern is obtained in the transmission spectrum as the result of multiple excited modes (excited and re-collected at the lead-in and lead-out splicing points) propagating in the ECF with different propagation constants. The interference pattern is non-uniform, indicating that there are more than two modes involved. Fast Fourier transform (FFT) is used to separate individual interference patterns that contribute to this complex spectrum and monitor their phase changes upon RI variation of the surrounding medium. In this way multiple RI sensitivities can be realized because each spatial frequency possesses a distinct sensitivity with respect to the surrounding RI. The operation of this device was validated by measuring the phase changes that occur when the sensing platform was subjected to solutions of different RIs or functionalized with different molecules. A biosensor was demonstrated based on this novel platform using biotin as the capturing probe to detect streptavidin with low non-specific adsorption. The proposed platform is reliable, cost-effective, and offers a potential label-free biosensing alternative to the widely used surface plasmon resonance (SPR) technique.

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Section: Introductionmentioning

confidence: 99%

Interferometric-type optical biosensor based on exposed core microstructured optical fiber

Nguyen

Hill

Warren‐Smith

et al. 2015

Sensors and Actuators B: Chemical

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“…Examples include on-chip embodiments of a Mach-Zehnder (11)(12)(13)(14) and Young Interferometer (15), dual polarization interferometer (16), porous Si (17) and nanoporous Al (18) sensors, diffraction optics technology (19), and the biological compact disk (BioCD) (20,21), as well as BSI (9,10,22). The Mach-Zehnder and Young dual polarization interferometers use wave guiding to monitor binding with surface interaction sensing, which requires relatively long sections of the channel to be coated with the target and large sample volumes to be introduced to facilitate micromolar to nanomolar detection limits.…”

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confidence: 99%

Free-Solution, Label-Free Molecular Interactions Studied by Back-Scattering Interferometry

Bornhop

Latham

Kussrow

et al. 2007

Science

191

216

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Free-solution, label-free molecular interactions were investigated with back-scattering interferometry in a simple optical train composed of a helium-neon laser, a microfluidic channel, and a position sensor. Molecular binding interactions between proteins, ions and protein, and small molecules and protein, were determined with high dynamic range dissociation constants (K d spanning six decades) and unmatched sensitivity (picomolar K d 's and detection limits of 10,000s of molecules). With this technique, equilibrium dissociation constants were quantified for protein A and immunoglobulin G, interleukin-2 with its monoclonal antibody, and calmodulin with calcium ion Ca 2+ , a small molecule inhibitor, the protein calcineurin, and the M13 peptide. The high sensitivity of back-scattering interferometry and small volumes of microfluidics allowed the entire calmodulin assay to be performed with 200 picomoles of solute.

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“…It can be also seen that the phase change curves of the reference channels, ∆φ 23 , seem to react to the glucose solutions at the concentrations of 0.1 and 0.2 wt.% showing small negative and positive phase changes, respectively. These phase changes are not anyhow direct reactions to RI changes, but caused by the cross-talk between the channel pairs which is a known phenomenon in multichannel YI sensors [15]. Also the different signs of these phase changes provide a further proof of the cross-talk induced phase changes instead of real sensor responses.…”

Section: Undisturbed Experimentsmentioning

confidence: 94%

Drift compensation using a multichannel slot waveguide Young interferometer

Aikio¹,

Hiltunen²,

Stenberg³

et al. 2015

J. Eur. Opt. Soc.-Rapid Publ.

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Polymeric integrated Young interferometer sensor chips utilizing a slot waveguide have demonstrated to be sensitive, to work at visible wavelengths, to be manufacturable by simple process, and to have a reduced sensitivity to temperature fluctuations. Although slot waveguide Young interferometers have these desirable features for low-cost rapid diagnostics, the sensor readout is disturbed by mechanical drifts of the sensing system. In this paper we demonstrate that mechanical drifts of the readout system can be compensated by using a multichannel slot waveguide Young interferometer having two reference waveguides and applying a drift compensation method based on the analysis of the spatial shifts of the interferogram fringes. The applicability of the drift compensation method was studied by conducting experiments with undisturbed and with mechanically disturbed setup to measure the phase changes induced by the changes of the bulk refractive index. By applying the drift compensation method, the sample induced phase change responses were extracted from up to 18 times larger measured phase changes in the disturbed experiments proving the applicability of the method with multichannel slot waveguide Young interferometers.

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Realization of a multichannel integrated Young interferometer chemical sensor

Cited by 97 publications

References 20 publications

Interferometric-type optical biosensor based on exposed core microstructured optical fiber

Interferometric-type optical biosensor based on exposed core microstructured optical fiber

Free-Solution, Label-Free Molecular Interactions Studied by Back-Scattering Interferometry

Drift compensation using a multichannel slot waveguide Young interferometer

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