Reasons to Reconsider Risk Associated With Power Morcellation of Uterine Fibroids

Abstract

The Genetic Background of Uterine Fibroid Development Molecular studies have revealed that, like other benign and malignant tumors, fibroids, in the majority of cases, are of 1 This article is freely accessible online.

A View on Uterine Leiomyoma Genesis through the Prism of Genetic, Epigenetic and Cellular Heterogeneity

“…Pathogenesis of benign metastasising (or parasitic) ULs is barely studied. There are assumptions that UL metastases might occur as a complication after laparoscopic surgery due to the morcellation of myomas and even that UL metastasising points towards the underestimated malignant potential of the initial tumour [ 229 , 230 , 231 , 232 ]. Regardless of UL metastasising mechanism, this phenomenon raises the need to update UL classification criteria as well as criteria to distinguish benign and malignant tumours.…”

“…Uterine leiomyomas and leiomyosarcomas often feature a similar spectrum of genetic alterations, although leiomyosarcoma undoubtedly demonstrates a more pronounced cytogenetic instability [ 202 , 235 , 236 , 237 ]. The fact that warrants special attention is that, whereas deletions in chromosomes 1 and 22 are associated with UL malignisation risk [ 231 , 238 ], chromothripsis is not [ 142 , 143 , 209 ]. Overall, UL malignisation is a considerably rare event and occurs more typically in histopathological variants [ 239 ].…”