Reassessing the Role of Subclinical Varicocele in Infertile Men With Impaired Semen Quality: A Prospective Study

Cantoro, Ubaldo; Polito, Massimo; Muzzonigro, Giovanni

doi:10.1016/j.urology.2015.01.015

Cited by 44 publications

(38 citation statements)

References 28 publications

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“…Similarly, Cantoro et al (44) and Prasivoravong et al (45) did not demonstrate statistically significant improvements. However, Cantoro et al embolized men with only subclinical varicocele, where TT demonstrated a non-statistically significant increase (44). This is comparison to 119 men used as control, who did not undergo intervention, but had a non-statistically significant decrease in TT.…”

Section: Varicocele Treated With Embolizationmentioning

confidence: 87%

“…Ten of thirteen studies without improved TT had starting average TT >450 ng/dL (7,24,25,30,33,35,36,44-46). Therefore, given the already normal TT, it remains unlikely that an appreciable increase in serum TT would be observed.…”

Section: Discussionmentioning

confidence: 99%

“…This same study repeated in men with hypogonadism may demonstrate different results. Additionally, Cantoro et al (44) prospectively analyzed 218 men with subclinical varicocele who underwent internal spermatic vein embolization compared to 119 men with subclinical varicocele refusing intervention. Although there was a rise in serum TT in the intervention group and a decrease in the observation group, neither was statistically significant at 6 months postoperatively.…”

Section: Subclinical Varicocele Repairmentioning

confidence: 99%

“…Despite initial promise that varicocele embolization results in improved TT (26,27), no studies apart from the initial single institution have reproduced this data (33,44-46). Currently it is difficult to recommend varicocele embolization to treat hypogonadism in men with varicocele.…”

Section: Varicocele Treated With Embolizationmentioning

confidence: 99%

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Effects of varicocelectomy on serum testosterone

Whelan

Levine

2016

Transl. Androl. Urol.

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Varicocele is most often surgically repaired due to male infertility, however, has recently been linked to low serum testosterone. This paper serves to review the current literature regarding varicocele and its subsequent repair on serum testosterone. Twenty-eight human studies were identified with fifteen showing improved serum testosterone after repair. The majority of the studies that demonstrated improvement had preoperative testosterone levels that were low or below normal. Additionally, multiple well-designed studies with control groups not undergoing surgical repair demonstrated significant difference between groups. This improvement was less observed in studies with normal preoperative serum testosterone. A majority of these patients studied were presenting for infertility. It remains to be determined if these findings can be reproduced in men without infertility. The findings suggest that microsurgical varicocele repair can improve serum testosterone in men with low levels preoperatively in appropriately counseled men. It remains to be seen whether varicocele repair can help prevent the development of low testosterone in the future or which patients are at risk of developing low testosterone due to varicocele.

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Section: Varicocele Treated With Embolizationmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Subclinical Varicocele Repairmentioning

confidence: 99%

Section: Varicocele Treated With Embolizationmentioning

confidence: 99%

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Effects of varicocelectomy on serum testosterone

Whelan

Levine

2016

Transl. Androl. Urol.

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“…Проведен метаанализ резуль-татов 36 опубликованных работ, в которых сравнивали уровень спонтанных беременностей, наступивших после лечения варикоцеле, и количество постопера-ционных осложнений. В зависимости от использован-ного метода оба показателя статистически значимо различались, но лучшие результаты лечения бесплодия не достигали 50 % [8,9].…”

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