Recent advance in nanomaterials for cancer immunotherapy

Hou, Yujing; Liu, Yapeng; Tang, Cheng; Tan, Yimin; Zheng, Xiao; Deng, Yan; Song, Li; He, Nongyue

doi:10.1016/j.cej.2021.134145

Cited by 23 publications

(13 citation statements)

References 194 publications

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“…181,182 Specific reported strategies for the application of BiOX in synergistic therapy are PTT/PDT therapy, 83,114 RT/CDT therapy, 73 RT/PDT/PTT therapy, 154 RCT/ST therapy, 108 SDT/ CDT therapy, 100 and chemo-PTT. 155 Although immune combination therapy has attracted more attention from researchers contemporarily, [183][184][185] to date there have been no relevant synergistic studies in this area for BiOX.…”

Section: Reviewmentioning

confidence: 99%

Recent developments in bismuth oxyhalide-based functional nanomaterials for biomedical applications

Chen

Miao

et al. 2022

Biomater. Sci.

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Section: Reviewmentioning

confidence: 99%

Recent developments in bismuth oxyhalide-based functional nanomaterials for biomedical applications

Chen

Miao

et al. 2022

Biomater. Sci.

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“…In recent years, with the rapid development of HTS technology, IR has been widely used in disease‐related research. 17 , 18 , 19 , 20 , 21 , 22 , 23 One study found that there were differences in the use of V and J genes in both β and IGH chains in patients with non‐small cell lung cancer (NSCLC). It was found that the clonality and diversity of the TCR repertoire in the early recurrence patients were increased and decreased, respectively, compared to the early non‐recurrence patients.…”

Section: Introductionmentioning

confidence: 99%

“…[14][15][16] In recent years, with the rapid development of HTS technology, IR has been widely used in disease-related research. [17][18][19][20][21][22][23] One study found that there were differences in the use of V and J genes in both β and IGH chains in patients with non-small cell lung cancer (NSCLC).…”

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confidence: 99%

“…[31][32][33][34] Dimer-avoided multiplex PCR (Dam-PCR) can be used to amplify all seven chains of the IR in the same PCR reaction system under the same conditions, with unique molecular IDs (UMIs), which can reduce the amplification bias and directly compare the gene expression level quantitatively. In this study, 16 normal Chinese participants were divided into two groups based on age: Group 1 (ages [19][20][21][22][23][24][25][26][27][28][29][30] and Group 2 (ages 50-67), with eight participants in each group. Peripheral blood samples from the participants were collected, RNA was extracted and Dam-PCR combined with HTS was used to analyze the IR of each participant.…”

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confidence: 99%

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Immune repertoire analysis of normal Chinese donors at different ages

et al. 2022

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Objectives: This study investigated the characteristics of the immune repertoire in normal Chinese individuals of different ages. Materials and Methods:In this study, all seven receptor chains from both B and T cells in peripheral blood of 16 normal Chinese individuals from two age groups were analyzed using high-throughput sequencing and dimer-avoided multiplex PCR amplification. Normal in this study is defined as no chronic, infectious or autoimmune disease within 6 months prior to blood draw. Results:We found that compared with the younger group, the clonal expression of T-cell receptor repertoire increased in the older group, while diversity decreased. In addition, we found that the T-cell receptor repertoire was more significantly affected by age than the B-cell receptor repertoire, including significant differences in the use of the unique TCR-alpha and TCR-beta V-J gene combinations, in the two groups of normal participants. We further analyzed the degree of complementarity determining region 3 sequence sharing between the two groups, and found shared TCR-alpha, TCR-gamma, immunoglobulin-kappa and immunoglobulin-lambda chain complementarity determining region 3 sequences in all subjects. Conclusion:Taken together, our study gives us a better understanding of the immune repertoire of different normal Chinese people, and these results can be applied to the treatment of age-related diseases. Immune repertoire analysis also allows us to observe participant's wellness, aiding in early-stage diagnosis. | INTRODUCTIONThe Adaptome is a collection of all the structural and functional diversity of T cell receptors (TCRs) and B cell receptors (BCRs) of an individual at any given time, which accurately and comprehensively reflects the dynamic changes of the immune system. 1 Within the Cailing Song and Wenjing Pan have contributed equally to this study and share first authorship.

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“…Recently, nanomaterials have received considerable attention owing to their specific physicochemical properties, such as high specific surface area, 1–3 tunable size and shape, 4–7 and multiple modification strategies for applications in various fields. 8–10 Monodispersity is a prerequisite to maintain the specific properties of the nanomaterials.…”

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confidence: 99%