Recent advancements in cardiovascular bioprinting and bioprinted cardiac constructs

Budharaju, Harshavardhan; Subramanian, Anuradha; Sethuraman, Swaminathan

doi:10.1039/d0bm01428a

Cited by 38 publications

(20 citation statements)

References 155 publications

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“…Stereolithography (STL) is a nozzle-free technology based on photo-sensitive polymer formulation. It utilizes ultraviolet (UV) or visible light to cure photosensitive polymers in a layer-by-layer manner (Budharaju et al, 2021). This technique is fast and provides accurate fabrication, that has resolutions ranging from 5to 300 µm (Raman et al, 2016).…”

Section: Stereolithographymentioning

confidence: 99%

“…Fibrinogen is a fibrous plasma protein that is actively involved in wound thrombosis, wound healing, angiogenesis. Fibrinogen is also involved in cell adhesion, migration, proliferation and differentiation (Budharaju et al, 2021). Fibrinogen is often used in 3D printing of cardiac tissues as it undergoes spontaneous gelation in the presence of thrombin and has docking sites for many proteins like VEGF, IL-1, albumin, Von Willebrand factor (Brown and Barker, 2014).…”

Section: Fibrinogenmentioning

confidence: 99%

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3D Bioprinting Technology – One Step Closer Towards Cardiac Tissue Regeneration

Chingale

Cheng

2022

Front. Mater.

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Cardiovascular diseases are one of the leading causes of death across the globe. Heart transplantation has been used for end stage heart failure patients. However, due to the lack of donors, this treatment option usually depends on multiple variables and the result varies due to immunological issues. 3D bioprinting is an emerging approach for in vitro generation of functional cardiac tissues for drug screening and cardiac regenerative therapy. There are different techniques such as extrusion, inkjet, or laser-based 3D printing that integrate multiple cell lines with different scaffolds for the construction of complex 3D structures. In this review, we discussed the recent progress and challenges in 3D bioprinting strategies for cardiac tissue engineering, including cardiac patches, in vitro cardiac models, valves, and blood vessels.

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Section: Stereolithographymentioning

confidence: 99%

Section: Fibrinogenmentioning

confidence: 99%

3D Bioprinting Technology – One Step Closer Towards Cardiac Tissue Regeneration

Chingale

Cheng

2022

Front. Mater.

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“…Myocardial infarction was started using the previously mentioned technique (Aden et al, 2015;Noshadi et al, 2017;Liu et al, 2018;Budharaju et al, 2021). The institute's animal welfare unit's methodologies were applied in the animal treatment and experimental methodology.…”

Section: Animal Model and Experimental Groups For Myocardial Infarctionmentioning

confidence: 99%

Engineering of injectable hydrogels associate with Adipose-Derived stem cells delivery for anti-cardiac hypertrophy agents

Long

Wang

et al. 2021

Drug Delivery

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Adipose-derived stem cells (ADSCs) treatment offers support to new methods of transporting baseline cell protein endothelial cells in alginate (A)/silk sericin (SS) lamellar-coated antioxidant system (ASS@L) to promote acute myocardial infarction. In the synthesized frames of ASS, the ratio of fixity modules, pores, the absorption and inflammation was detected at ka (65ka), 151 ± 40.12 lm, 92.8%, 43.2 ± 2.58 and 30.10 ± 2.1. In this context, ADSC-ASS@L was developed and the corresponding material was stable and physically chemical for the development of cardiac regenerative applications. ADSC-ASS@L injectable hydrogels in vitro examination demonstrated higher cell survival rates and pro-angiogenic and pro-Inflammatory expression factors, demonstrating the favorable effect of fractional ejections, fibre-areas, and low infracture vessel densities. In successful cardiac damage therapy in acute myocardial infarction the innovative ADSC injection hydrogel approach may be helpful. The approach could also be effective during coronary artery hypertrophy for successful heart damage treatment.

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“…Yet, due to the novelty of this niche market, no bioprinter reviews that we could find focus on the latest commercially available low-cost systems. Specifically, the previously published reviews either give an overview of the entire bioprinting field (with a focus on the evolution of the printing technologies), 9–13 review bio-inks, 14–27 or discuss specific applications (e.g., cardiovascular tissue models, 14,28–35 bone tissue models, 36–48 cartilage tissue models, 42,47,49–52 nerve tissue models, 53–61 skin tissue models, 48,62–66 and in vivo bioprinting 67–…”

Section: Introductionmentioning

confidence: 99%

Review of Low-Cost 3D Bioprinters: State of the Market and Observed Future Trends

et al. 2021

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Three-dimensional (3D) bioprinting has become mainstream for precise and repeatable high-throughput fabrication of complex cell cultures and tissue constructs in drug testing and regenerative medicine, food products, dental and medical implants, biosensors, and so forth. Due to this tremendous growth in demand, an overwhelming amount of hardware manufacturers have recently flooded the market with different types of low-cost bioprinter models—a price segment that is most affordable to typical-sized laboratories. These machines range in sophistication, type of the underlying printing technology, and possible add-ons/features, which makes the selection process rather daunting (especially for a nonexpert customer). Yet, the review articles available in the literature mostly focus on the technical aspects of the printer technologies under development, as opposed to explaining the differences in what is already on the market. In contrast, this paper provides a snapshot of the fast-evolving low-cost bioprinter niche, as well as reputation profiles (relevant to delivery time, part quality, adherence to specifications, warranty, maintenance, etc.) of the companies selling these machines. Specifically, models spanning three dominant technologies—microextrusion, droplet-based/inkjet, and light-based/crosslinking—are reviewed. Additionally, representative examples of high-end competitors (including up-and-coming microfluidics-based bioprinters) are discussed to highlight their major differences and advantages relative to the low-cost models. Finally, forecasts are made based on the trends observed during this survey, as to the anticipated trickling down of the high-end technologies to the low-cost printers. Overall, this paper provides insight for guiding buyers on a limited budget toward making informed purchasing decisions in this fast-paced market.

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Recent advancements in cardiovascular bioprinting and bioprinted cardiac constructs

Abstract: Three-dimensionally bioprinted cardiac constructs with biomimetic bioink helps to create native-equivalent cardiac tissues to treat patients with myocardial infarction.

Cited by 38 publications

References 155 publications

3D Bioprinting Technology – One Step Closer Towards Cardiac Tissue Regeneration

3D Bioprinting Technology – One Step Closer Towards Cardiac Tissue Regeneration

Engineering of injectable hydrogels associate with Adipose-Derived stem cells delivery for anti-cardiac hypertrophy agents

Review of Low-Cost 3D Bioprinters: State of the Market and Observed Future Trends

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