Recent Advances in Application of Poly-Epsilon-Caprolactone and its Derivative Copolymers for Controlled Release of Anti-Tumor Drugs

Abstract

Recent advances in applying poly-epsilon-caprolactone for controlled delivery and targeting release of chemical anti-tumor drugs were summarized in this mini-review. Benefited from the efforts of scientists all over the world, various chemotherapeutic drug delivery systems based on different formulations of poly-epsilon-caprolactone related materials have been evaluated. It has been widely recognized that the introduction of of poly-epsilon-caprolactone components into drug delivery systems would increase drug loading capacity, decrease leakage, prolong releasing period and result in controllable releasing rate. Especially with the development of environment-responsive delivery systems (pH-, thermo-, magnetic field- and light-responsive drug carriers), enhanced tumor cell targeting potential, as well as decreased systemic toxicity would be realized.

Recent progress in nanocomposites of carbon dioxide fixation derived reproducible biomedical polymers

“…Based on the ways in which they respond to heat, biomedical polymer materials could be classified as thermoplastics, thermosets and elastomers. Considering their origins, they could also be classified into bio-based and fossil fuelbased biomedical polymer materials (as shown in Table 1) (Endres and Siebert-Raths, 2011;Annabi et al, 2014;Sun et al, 2017;Hacker et al, 2019). In general, the bio-based polymer materials (also known as naturally-derived polymers) produced from reproducible plants, animals, and microorganisms, have less contribution to the greenhouse effect than their fossil fuel-based counterparts (Cui et al, 2011;Jayaramudu et al, 2013;Malwela and Ray, 2015;Jammalamadaka and Tappa, 2018;Sun Y. et al, 2019).…”

“…In the past few decades, nanotechnology has been proved to be effective in improving the properties of traditional materials (Bosco et al, 2015;Li et al, 2016;Sun et al, 2017;Zheng et al, 2017;Iravani, 2020;Allahyari et al, 2021;Fang et al, 2021;Sajjadi et al, 2021;Tamburaci and Tihminlioglu, 2021;Wang et al, 2021;Iravani, 2022). And many scientists have been engaged in developing new kinds of eco-friendly biomedical polymers by adding various nanomaterials into CO 2 fixation derived polymers.…”

Zinc and Magnesium Complexes Bearing Oxazoline-Derived Ligands and Their Application for Ring Opening Polymerization of Cyclic Esters

“…1,2 Polylactide (PLA) and poly(ε-caprolactone) (PCL) were widely researched as biodegradable polymers which had applications in many fields such as textiles, packaging films, tissue engineering, and drug delivery. 3−8 The ring opening polymerization (ROP) of lactide (LA) and ε-caprolactone (ε-CL) was the universal method to produce PLA and PCL. The microstructures of the polymer had a significant effect ranging from the mechanical to degradation properties of PLA.…”

“…As a tremendous development in the petroleum industry, the polymers produced from petrochemicals have accessed to a wide range of applications. As petroleum resources could not be renewed and because of the continuous pollution of petrochemical-based plastic products to the environment, biodegradable polymers were widely investigated as substitutes. , Polylactide (PLA) and poly­(ε-caprolactone) (PCL) were widely researched as biodegradable polymers which had applications in many fields such as textiles, packaging films, tissue engineering, and drug delivery. − The ring opening polymerization (ROP) of lactide (LA) and ε-caprolactone (ε-CL) was the universal method to produce PLA and PCL. The microstructures of the polymer had a significant effect ranging from the mechanical to degradation properties of PLA. − Further application of PLA and PCL materials depended on the polymer properties and costs.…”