Recent advances in biological macromolecule based tissue-engineered composite scaffolds for cardiac tissue regeneration applications

Chandika, Pathum; Heo, Seong‐Yeong; Kim, Tae-Hee; Oh, Gun‐Woo; Kim, Geun-Hyeong; Kim, Min-Sung; Jung, Won‐Kyo

doi:10.1016/j.ijbiomac.2020.08.054

Cited by 35 publications

(14 citation statements)

References 254 publications

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“…Polymers are the most promising materials to obtain these requirements, because they are available in a wide variety of compositions, properties, and shapes, and allow the processing of complex structures. In this way, the use of natural polymers, such as proteins and polysaccharides, is especially interesting, since they are main components of or have similar macromolecular properties to the native extracellular matrix (ECM) [9,10], e.g., proteins such as collagen [11], elastin [12] or even combinations of both proteins [13]. Collagen is the biopolymer that is the most abundant in animals and, therefore, it is one of the most used materials in TE for scaffold production.…”

Section: Introductionmentioning

confidence: 99%

Rheological and Microstructural Evaluation of Collagen-Based Scaffolds Crosslinked with Fructose

et al. 2021

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In recent years, tissue engineering research has led to the development of this field by designing scaffolds with better properties that can fulfill its purpose of better and faster tissue regeneration, consequently improving people’s quality of life. Scaffolds are matrices, predominantly composed of polymeric materials, whose main function is to offer support for cell adhesion and subsequent growth, leading to the regeneration of the damaged tissue. The widely used biopolymer in tissue engineering is collagen, which is the most abundant protein in animals. Its use is due to its structure, biocompatibility, ease of modification, and processability. In this work, collagen-based scaffolds were developed with different concentrations and processing techniques, by obtaining hydrogels and aerogels that were characterized with an emphasis on their morphology and mechanical properties. Moreover, fructose was added in some cases as a chemical crosslinking agent to study its influence on the scaffolds’ properties. The obtained results revealed that the scaffolds with higher collagen concentrations were more rigid and deformable. Comparing both systems, the aerogels were more rigid, although the hydrogels were more deformable and had higher pore size homogeneity. Fructose addition produced a slight increase in the critical strain, together with an increase in the elastic modulus.

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Section: Introductionmentioning

confidence: 99%

Rheological and Microstructural Evaluation of Collagen-Based Scaffolds Crosslinked with Fructose

et al. 2021

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“…Natural polymers, such as polysaccharides and proteins, possess many favorable properties, including biocompatibility and biodegradability, and have been applied as scaffold in cardiac regeneration because of their similarity with the natural tissues and the ability to facilitate cell adhesion, proliferation, and differentiation [ 38 ]. In addition, the presence of many functional groups allows the polymer backbone to be easily functionalized, and the physic-chemical properties to be finely tuned [ 39 ].…”

Section: Biomaterials For Cardiac Regenerationmentioning

confidence: 99%

Polymeric Biomaterials for the Treatment of Cardiac Post-Infarction Injuries

et al. 2021

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Cardiac regeneration aims to reconstruct the heart contractile mass, preventing the organ from a progressive functional deterioration, by delivering pro-regenerative cells, drugs, or growth factors to the site of injury. In recent years, scientific research focused the attention on tissue engineering for the regeneration of cardiac infarct tissue, and biomaterials able to anatomically and physiologically adapt to the heart muscle have been proposed as valuable tools for this purpose, providing the cells with the stimuli necessary to initiate a complete regenerative process. An ideal biomaterial for cardiac tissue regeneration should have a positive influence on the biomechanical, biochemical, and biological properties of tissues and cells; perfectly reflect the morphology and functionality of the native myocardium; and be mechanically stable, with a suitable thickness. Among others, engineered hydrogels, three-dimensional polymeric systems made from synthetic and natural biomaterials, have attracted much interest for cardiac post-infarction therapy. In addition, biocompatible nanosystems, and polymeric nanoparticles in particular, have been explored in preclinical studies as drug delivery and tissue engineering platforms for the treatment of cardiovascular diseases. This review focused on the most employed natural and synthetic biomaterials in cardiac regeneration, paying particular attention to the contribution of Italian research groups in this field, the fabrication techniques, and the current status of the clinical trials.

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“…(i) Ex vivo tissue engineering involves the isolation of stem cells from the donor to be seeded on an external scaffold in a suitable environment in bioreactors to stimulate cell proliferation and differentiation into the desired tissue [16][17][18][19]. The produced tissue is then implanted into the desired tissue, so it must be of the same size and shape as the defect area, the scaffold degrades over time to permit the substitution with the newly regenerated tissues [20][21][22][23]. This approach presents scaffolds of good mechanical properties and allows the use of many biomaterials [24][25][26][27][28]; however, it requires sophisticated optimization of the conditions in the bioreactors to allow initial cell proliferation, high cost, donor site morbidity, and rejection of the implanted tissue may occur [29].…”

Section: Introductionmentioning

confidence: 99%

Biomaterials for Tissue Engineering Applications and Current Updates in the Field: A Comprehensive Review

2022

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Tissue engineering has emerged as an interesting field nowadays; it focuses on accelerating the auto-healing mechanism of tissues rather than organ transplantation. It involves implanting an In Vitro cultured initiative tissue or a scaffold loaded with tissue regenerating ingredients at the damaged area. Both techniques are based on the use of biodegradable, biocompatible polymers as scaffolding materials which are either derived from natural (e.g. alginates, celluloses, and zein) or synthetic sources (e.g. PLGA, PCL, and PLA). This review discusses in detail the recent applications of different biomaterials in tissue engineering highlighting the targeted tissues besides the in vitro and in vivo key findings. As well, smart biomaterials (e.g. chitosan) are fascinating candidates in the field as they are capable of elucidating a chemical or physical transformation as response to external stimuli (e.g. temperature, pH, magnetic or electric fields). Recent trends in tissue engineering are summarized in this review highlighting the use of stem cells, 3D printing techniques, and the most recent 4D printing approach which relies on the use of smart biomaterials to produce a dynamic scaffold resembling the natural tissue. Furthermore, the application of advanced tissue engineering techniques provides hope for the researchers to recognize COVID-19/host interaction, also, it presents a promising solution to rejuvenate the destroyed lung tissues. Graphical abstract

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Recent advances in biological macromolecule based tissue-engineered composite scaffolds for cardiac tissue regeneration applications

Cited by 35 publications

References 254 publications

Rheological and Microstructural Evaluation of Collagen-Based Scaffolds Crosslinked with Fructose

Rheological and Microstructural Evaluation of Collagen-Based Scaffolds Crosslinked with Fructose

Polymeric Biomaterials for the Treatment of Cardiac Post-Infarction Injuries

Biomaterials for Tissue Engineering Applications and Current Updates in the Field: A Comprehensive Review

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