Recent Advances in C–H Functionalization

New Trends in Oxidative Functionalization of Carbon–Hydrogen Bonds: A Review

“…Compound 16 exhibited activity in catalytic highly stereoselective oxidation of 1,2-cyclohexane with m-CPBA ( Table 1). Cations of cobalt and nickel gave cylinder-type complexes phenylsilsesquioxane [(PhSiO 1,5 ) 10 (CoO) 5 (NaOH)] (compound 16) [227] and (PhSiO 1.5 ) 12 (NiO) 6 (NaCl) (compound 17) [228]. Their "drum-like" structures are presented in Figures 11 and 12 respectively.…”

“…This review is devoted to functionalization of carbon-hydrogen bonds [1][2][3][4][5][6][7][8][9][10][11][12][13] in various organic compounds, which is a very important process both from academic and practical point of view. Replacing hydrogen atoms in carbon-hydrogen compounds by functional groups X leads to valuable functionalized C-X compounds (Scheme 1a).…”

Asymmetric Synthesis through C–H Activation

“…The traditionally used carbenoid, derived from ethyl diazoacetate, is a very reactive and hence quite unselective species. Although this has been addressed in recent years by the development of copper and silver scorpionate complexes and other catalysts [103,198 -202] , the major breakthrough in the area of rhodium carbenoid chemistry has been the development of donor/acceptor -substituted carbenoid precursors, which give carbenoid complexes that are much more stable and hence more chemoselective [11,42,43,85,130,203,204] . This has been developed to the extent that many transformations via this route can be considered strategic synthetic transformations equivalent to many classical organic reactions [66] .…”

Synthesis and antimicrobial evaluation of novel analogues of dehydroabietic acid prepared by C H-Activation

“…rings B and C. (Figure 2, left) This is not very surprising, since the western hemisphere (i.e., ring A) of the molecule is devoid of chemically reactive handles other than the carboxylic acid itself. [4] Within the last decade, C-H activation has emerged as a very powerful toolset in organic synthesis [5][6][7][8]. The combination of strongly coordinating, bidentate directing groups with late transition metals led to the introduction of a variety of substituents on usually chemically inert C(sp 2 )-and C(sp 3 )-carbons.…”