Recent advances in herbal medicine for treatment of liver diseases

Abstract

Out of the several leads obtained from plant sources as potential hepatoprotective agents, silymarin, andrographolide, neoandrographolide, curcumin, picroside, kutkoside, phyllanthin, hypophyllanthin, and glycyrrhizin have been established as potent hepatoprotective agents. The hepatoprotective potential of several herbal medicines has been clinically evaluated. Significant efficacy has been seen with silymarin, glycyrrhizin and Liv-52 in treatment of hepatitis, alcoholic liver disease and liver cirrhosis.

Hepatoprotective Effect of Microemulsion-Based System of Prunus Cerasus Kernel Extract on CCL4-induced Liver Damage in Mice

“…They are the potential sources for new therapeutic agents that can be used to inhibit hepatic injuries. Natural products rich in triterpenes, flavonoids or polyphenols are now used as strong hepatoprotective agents in experimental liver-injury and animal models (36,37). In the current study, with regard to the well-known antioxidant and anti-inflammatory effects of Prunus cerasus kernel, hepatoprotective effect of ME-based system of Prunus cerasus kernel extract against CCL 4 -induced liver damage in mice was studied.…”

Hepatoprotective activity of Eclipta alba against carbon tetrachloride-induced hepatotoxicity in albino rats

“…The traditional herbal treatments for liver diseases have reached new dimension with the support of modern evidence-based medicine in clinical studies. 17 CCl 4 is commonly used for induction of experimental liver toxicity in animal models. Its metabolites such as trichloromethyl radical (CCl 3 ) and trichloromethyl peroxy radical are involved in the pathogenesis of liver toxicity.…”

Effect of Dalechampia indica Wight Extract Fractions on Behavioral and Biochemical Abnormalities following Ischemia-Reperfusion Insult in Rats

“…8 Though there are various promising ways of approach for treatment of stroke, our most efficacious therapy remain neuroprotective effect of natural compounds from herbs with multifactorial function such as anti-oxidation, anti-inflammation, calcium antagonization, anti-apoptosis, and neurofunctional regulation. 9 Preventive strategies such as Lifestyle modifications, control of hypertension, hyperglycemia, hyperlipidemia, smoking and treatment of cardiac condition has also produced encouraging results. 10 Dalechampia indica Wight (Euphorbiaceae), commonly called as aliparnika found in dry hills of Andhra Pradesh and Tamil Nadu.…”