Recent advances in inorganic nanomaterials for wound-healing applications

Nethi, Susheel Kumar; Das, Sourav; Patra, Chitta Ranjan; Mukherjee, Sudip

doi:10.1039/c9bm00423h

Cited by 261 publications

(197 citation statements)

References 176 publications

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“…Cu also stimulates angiogenesis and collagen deposition, which are key elements in wound healing [ 420 ]. The use of copper-based biomaterials is cost-effective compared to other vital materials based on gold and silver [ 421 ].…”

Section: Nanobiomaterialsmentioning

confidence: 99%

Comprehensive Survey on Nanobiomaterials for Bone Tissue Engineering Applications

et al. 2020

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One of the most important ideas ever produced by the application of materials science to the medical field is the notion of biomaterials. The nanostructured biomaterials play a crucial role in the development of new treatment strategies including not only the replacement of tissues and organs, but also repair and regeneration. They are designed to interact with damaged or injured tissues to induce regeneration, or as a forest for the production of laboratory tissues, so they must be micro-environmentally sensitive. The existing materials have many limitations, including impaired cell attachment, proliferation, and toxicity. Nanotechnology may open new avenues to bone tissue engineering by forming new assemblies similar in size and shape to the existing hierarchical bone structure. Organic and inorganic nanobiomaterials are increasingly used for bone tissue engineering applications because they may allow to overcome some of the current restrictions entailed by bone regeneration methods. This review covers the applications of different organic and inorganic nanobiomaterials in the field of hard tissue engineering.

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Section: Nanobiomaterialsmentioning

confidence: 99%

Comprehensive Survey on Nanobiomaterials for Bone Tissue Engineering Applications

et al. 2020

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“…For instance, Acticoat TM produces wound dressing consists of silver nanoparticle wich can be released to the wound. Electrospun nanofibers (Rolandi et al, 2014), synthetic fibrin polymers (Chan et al, 2015), and nanocarriers for drug delivery (Nethi et al, 2019) are other nanostructured materials which are in FDA approval phase. In addition, thrombin@Fe 3 O 4 nanoparticles which has been used as a hemostatic agent in internal bleeding (Shabanova et al, 2018), PolySTAT, chitosan nanoparticles, and electrospun fibers are hemostasis materials approved by FDA.…”

Section: Nanomaterials For Blood Coagulation Monitoring and Treatmentsmentioning

confidence: 99%

Technology Advancements in Blood Coagulation Measurements for Point-of-Care Diagnostic Testing

Aria

Erten

Yalçın

2019

Front. Bioeng. Biotechnol.

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In recent years, blood coagulation monitoring has become crucial to diagnosing causes of hemorrhages, developing anticoagulant drugs, assessing bleeding risk in extensive surgery procedures and dialysis, and investigating the efficacy of hemostatic therapies. In this regard, advanced technologies such as microfluidics, fluorescent microscopy, electrochemical sensing, photoacoustic detection, and micro/nano electromechanical systems (MEMS/NEMS) have been employed to develop highly accurate, robust, and cost-effective point of care (POC) devices. These devices measure electrochemical, optical, and mechanical parameters of clotting blood. Which can be correlated to light transmission/scattering, electrical impedance, and viscoelastic properties. In this regard, this paper discusses the working principles of blood coagulation monitoring, physical and sensing parameters in different technologies. In addition, we discussed the recent progress in developing nanomaterials for blood coagulation detection and treatments which opens up new area of controlling and monitoring of coagulation at the same time in the future. Moreover, commercial products, future trends/challenges in blood coagulation monitoring including novel anticoagulant therapies, multiplexed sensing platforms, and the application of artificial intelligence in diagnosis and monitoring have been included.

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“…On the other side, wounds that do not cure in a consistent period contributing to further problems, such as inflammation and healing issues are classified as chronic wounds. Chronic wounds include vascular ulcers, pressure ulcers, and diabetic ulcers (Nethi et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…Wounds have an enormous financial burden on healthcare systems globally, representing more than $25 billion annually in the US alone (Sen et al, 2009;Das and Baker, 2016). The wound care products market has expanded massively to over US$ 15 billion, including US$ 12 billion to deal with wound scars (Nethi et al, 2019). Unexpectedly, healthcare providers and patients in the US are charged a cost of around US$ 9 billion annually to perform lower limb amputations resulting from diabetic foot ulcers (Falanga, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…Also, bacterial infection and the slow separation of fibroblasts may hinder the healing process, contributing to swelling, local pains, and even thus threatening complications (Lai and Rogach, 2017;Ren et al, 2019). Thus, there is a critical need to build alternative solutions to address unmet health challenges involved in wound care management (Nethi et al, 2019). Nanotechnology is an increasingly growing scientific area and has been used to solve various biological issues, both therapeutic and diagnostic.…”

Section: Introductionmentioning

confidence: 99%

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Surface Engineered Metal-Organic Frameworks (MOFs) Based Novel Hybrid Systems for Effective Wound Healing: A Review of Recent Developments

Chen

Cai

et al. 2020

Front. Bioeng. Biotechnol.

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Wounds present serious medical complications and their healing requires strategies that promote angiogenesis, deposition of collagen as well as re-epithelialization of wounds. Currently used conventional wound healing strategies have become less effective due to various issues associated with them. Thus, novel strategies are needed to be developed for early and effective healing of wounds. Metal-organic frameworks (MOFs), formed by linking of metal ions through organic bridging ligands, are highly tunable hybrid materials and have attracted more considerable scientific attention due to their charming and prominent properties, such as abundant pore structures and multiple functionalities. Surface engineering of MOFs with unique ligands can overcome issues associated with conventional wound healing methods, thus resulting in early and effective wound healing. This review has been undertaken to elaborate wound healing, and the use of surface engineered MOFs for effective and rapid wound healing. The process of wound healing will be discussed followed by a detailed review of recent literature for summarizing applications of surface engineered MOFs for wound healing. MOFs wound healing will be discussed in terms of their use as antibacterial agents, therapeutic delivery vehicles, and dressing systems in wound healing.

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Recent advances in inorganic nanomaterials for wound-healing applications

Cited by 261 publications

References 176 publications

Comprehensive Survey on Nanobiomaterials for Bone Tissue Engineering Applications

Comprehensive Survey on Nanobiomaterials for Bone Tissue Engineering Applications

Technology Advancements in Blood Coagulation Measurements for Point-of-Care Diagnostic Testing

Surface Engineered Metal-Organic Frameworks (MOFs) Based Novel Hybrid Systems for Effective Wound Healing: A Review of Recent Developments

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