Recent Advances in Microencapsulation Technology and Equipment

Li, Shun Por; Kowarski, Chana R.; Feld, Kenneth M.; Grim, Wayne M.

doi:10.3109/03639048809151975

Cited by 56 publications

(31 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Magnetic carriers receive magnetic responses to a magnetic field from incorporated materials that are used for magnetic microspheres such as chitosan, dextran etc [3]. The different types of magnetic microspheres include:…”

Section: Types Of Magnetic Microspheresmentioning

confidence: 99%

See 1 more Smart Citation

Magnetic Microspheres: A Novel Drug Delivery System

Farah

2016

JAPLR

View full text Add to dashboard Cite

A well designed controlled drug delivery system can provide a therapeutic amount of drug to the proper site in the body and then maintain the desired drug concentration for the specific period of time. A number of approaches are available in delivering therapeutic substance to the target site in sustained and controlled release fashion. One such approach is using magnetic microspheres as carriers for drugs. Microsphere drug delivery system has gained vast attention due to its diverse applications that range from targeting the drug to specific site to imaging and helping the diagnostic features.One of its important application is that it is used for targeting tumors using anticancer drugs. Being more stable, it has an advantage over other delivery systems like liposomes. The main objectives of this review are to highlight some important aspects of magnetic microspheres as a novel drug delivery system. The review shall cover definitions, concepts, types, mechanism of targeting, evaluation and characteristics of magnetic microspheres as well as various methods and techniques used in their preparations. The review also entails various applications and future prospects of magnetic microspheres.

show abstract

Section: Types Of Magnetic Microspheresmentioning

confidence: 99%

“…Magnetic microspheres are very much important which localizes the drug to the disease site. In this respect, larger amount of freely circulating drug can be replaced by smaller amount of magnetically targeted drug [3].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Microspheres: A Novel Drug Delivery System

Farah

2016

JAPLR

View full text Add to dashboard Cite

show abstract

“…Microspheres provide several advantages over other sustained release systems, especially matrix type tablets. They can be widely distributed throughout the gastrointestinal tract, improve drug absorption and minimize side effects due to localized buildup of irritating drugs against the gastrointestinal mucosa (Li et al, 1988).…”

Section: Introductionmentioning

confidence: 99%

A Comparative Evaluation of Drug Release and Permeability of Ethylcellulose, Cellulose Acetate and Eudragit RS100 Microspheres

Katakam¹,

Diaf²,

Dey³

et al. 2014

IJSRK

View full text Add to dashboard Cite

Abstract. Present study aims at comparative evaluation of drug release and permeability of diclofenac sodium loaded ethylcellulose (EC), cellulose acetate (CA) and eudragit (EU) microspheres. Microspheres of EC, CA and EU containing diclofenac sodium were prepared by an emulsification-solvent evaporation (oil-in-oil, o/o) method and were investigated for a comparative evaluation of various parameters. The microspheres were found discrete, free flowing, multinucleate, monolithic and spherical. About 5560% of all microspheres prepared were in the size range of -20+30 (715 m) mesh size. The encapsulation efficiency was in the range of 97.1106.4% with various polymers. The wall thickness of microspheres was in the range of 13.69-74.97m which depended on polymer employed and was directly proportional to polymer concentration. Diclofenac release from the microspheres was slow over longer periods of time and depended on the polymer used and coat:core ratio. Release was diffusion controlled and followed first order kinetics. Good linear relationships were observed between percent coat, wall thickness and release rate constant with all the three polymers. The slopes of percent coat vs release rate (k 1 ) plots were found to be 0.4117, 0.2351 and 0.9762; and those of wall thickness (h) vs drug release rate (k 1 ) plots were found 0.2549, 0.1863 and 0.7850 respectively for EC, CA and EU microspheres. The lower the slope the better is the controlling effect. Cellulose acetate exhibited better release-controlling effect than that of ethylcellulose and eudragit. The increasing order of diclofenac release rate and permeability observed with various microspheres was, cellulose acetate < ethylcellulose < eudragit RS100. The possible permeability of drug from the prepared porous micrsopheres could be due to osmotic pressure generated by diclofenac.

show abstract

“…Esse processo é primariamente dependente do pH do meio, sendo a natureza ácida ou básica deste manipulada para a obtenção de microcápsulas (LI et al, 1988). Nos processos de coacervação complexa, normalmente se observa a presença de mais de um hidrocolóide.…”

Section: Modificações Do Leito De Jorro Convencionalunclassified

“…O emprego desses sistemas possibilita o mascaramento dos sabores e dos odores indesejáveis eventualmente apresentados pelo princípio ativo, podendo também protegê-lo de fatores ambientais ou mesmo proteger o ambiente dos riscos proporcionados pelo material encapsulado. Além disso, uma aplicação de grande importância das microcápsulas na área farmacêutica consiste na modulação da liberação dos princípios ativos, que pode proporcionar ao medicamento uma liberação prolongada ou sítio-específica, com inúmeras vantagens terapêuticas e econômicas (LI et al, 1988).…”

Section: I N N T T R R O O D D U U ç ç ã ã O O 1 Introduçãounclassified

Estudo da técnica de leito de jorro convencional para secagem de microcápsulas de caseína e pectina

Marreto¹

View full text Add to dashboard Cite

Recent Advances in Microencapsulation Technology and Equipment

Cited by 56 publications

References 1 publication

Magnetic Microspheres: A Novel Drug Delivery System

Magnetic Microspheres: A Novel Drug Delivery System

A Comparative Evaluation of Drug Release and Permeability of Ethylcellulose, Cellulose Acetate and Eudragit RS100 Microspheres

Estudo da técnica de leito de jorro convencional para secagem de microcápsulas de caseína e pectina

Contact Info

Product

Resources

About