Recent advances in mixing-induced nanoprecipitation: from creating complex nanostructures to emerging applications beyond biomedicine

Abstract

Mixing-induced nanoprecipitation (MINP) is an efficient, controllable, scalable, versatile, and cost-effective technique for the preparation of nanoparticles. In addition to the formulation of drugs, MINP has attracted tremendous interests in...

Supramolecular Cu(ii) nanoparticles supported on a functionalized chitosan containing urea and thiourea bridges as a recoverable nanocatalyst for efficient synthesis of 1H-tetrazoles

“…General procedure for the synthesis of 5-substituted-1Htetrazoles derivatives 5a-q catalyzed by CS-TDI-PMDA-TS-Cu(II) nanocatalyst (1) In a screwed test tube, a mixture of aryl aldehyde (4a-q, 1.00 mmol), malononitrile (2, 1.10 mmol), and sodium azide (3, 1.50 mmol) was heated in the presence of CS-TDI-PMDA-TS-Cu(II) nanocatalyst (1, 20 mg) under solvent-free conditions at 110 °C in an oil bath and stirred for the time indicated in Table 1. The reaction progress was monitored by TLC (n-hexane/EtOAc, 1 : 1).…”

“…Aerward, the optimized conditions were expanded to other aromatic aldehydes 4b-q to investigate the scope of reaction for synthesizing of 1H-tetrazole derivatives in the presence of CS-TDI-PMDA-TS-Cu(II) nanocatalyst (1). A diversity of aromatic carbocyclic or heterocyclic aldehydes 4a-q well survived to involve smoothly in the optimized conditions.…”

“…X-Ray diffraction spectroscopy (XRD) analysis. The XRD was also employed to study the crystalline structures of CS-TDI-PMDA-TS-Cu(II) nanocatalyst (1). The wide-angle XRD patterns shown in Fig.…”

“…Pristine biopolymers and especially their chemically-modied derivatives have been recently found to serve as appropriate leading materials in many research and technology areas including vaccines, medical practice, antibacterial and wound healing dressing, naturally degradable sensors, environmental engineering, buildings, energy storage devices, electrochemistry, food packaging, and replacing conventional petrochemical-based polymers as well as appropriate supports for low-toxic and biodegradable catalytic systems. [1][2][3][4][5][6][7][8][9][10][11] The use of appropriate catalytic systems to prepare important medicinal compounds through environmental-friendly protocols has received signicant interest in both academia and industry in recent decades. Two types of catalytic systems are homogeneous and heterogeneous.…”

“…Furthermore, the CS-TDI-PMDA-TS-Cu(II) nanocatalyst (1) is liberated and can start next catalytic cycle. Comparison of the catalytic activity of CS-TDI-PMDA-TS-Cu(II) nanocatalyst(1) in the synthesis of tetrazole derivatives with other catalytic systems…”