Recent Advances in Poly(α-L-glutamic acid)-Based Nanomaterials for Drug Delivery

Zhang, Yu; Song, Wenliang; Lu, Yiming; Xu, Yixin; Wang, Changping; Yu, Deng‐Guang; Kim, Il

doi:10.3390/biom12050636

Cited by 75 publications

(56 citation statements)

References 174 publications

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“…We believe that our findings are useful in the field of biomedical engineering aimed at the regeneration of muscular tissue, which requires the knowledge of cell-substrate interaction [ 3 ]. Additionally, our findings could also be applied in the development of scaffolds with tuneable physicochemical and biological properties for biomedical applications [ 58 , 59 ].…”

Section: Resultsmentioning

confidence: 99%

Tuning Myogenesis by Controlling Gelatin Hydrogel Properties through Hydrogen Peroxide-Mediated Cross-Linking and Degradation

Mubarok

Elvitigala

Sakai

2022

Gels

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Engineering skeletal muscle tissue in vitro is important to study the mechanism of myogenesis, which is crucial for regenerating muscle cells. The physicochemical properties of the cellular microenvironment are known to govern various cell behaviours. Yet, most studies utilised synthetic materials to model the extracellular matrix that suffers from cytotoxicity to the cells. We have previously reported that the physicochemical property of hydrogels obtained from horseradish peroxidase (HRP)-catalysed cross-linking could be controlled by a simple adjustment to the exposure time to air containing H2O2. In this study, we evaluated the influence of physicochemical properties dynamics in the gelatin possessing phenol groups (Gelatin-Ph) hydrogel to regulate the myogenesis in vitro. We controlled the Young’s modulus of the Gelatin-Ph hydrogel by tuning the air containing 16 ppm H2O2 exposure time for 15–60 min. Additionally, prolonged exposure to air containing H2O2 also induced Gelatin-Ph degradation. Myoblasts showed higher adhesion and myotube formation on stiff hydrogel (3.53 kPa) fabricated through 30 min of exposure to air containing H2O2 compared to those on softer hydrogel (0.77–2.79 kPa) fabricated through 15, 45, and 60 min of the exposure. These results demonstrate that the myogenesis can be tuned by changes in the physicochemical properties of Gelatin-Ph hydrogel mediated by H2O2.

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Section: Resultsmentioning

confidence: 99%

Tuning Myogenesis by Controlling Gelatin Hydrogel Properties through Hydrogen Peroxide-Mediated Cross-Linking and Degradation

Mubarok

Elvitigala

Sakai

2022

Gels

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“…For example, from a standpoint of technique combination, 3D printing, as a flexible method in creating complex micro structures within the printed parts [ 84 , 85 , 86 , 87 ], can be combined with both electrospinning and casting for generating novel polymeric hybrids. From a standpoint of tailoring polymer carriers, insoluble inert polymers can be integrated with biodegradable polymers for manipulating drug release behaviors [ 88 ]. From a standpoint of drug delivery applications, the present hybrid films can be explored for many similar active ingredients that dual-phase release can ensure a better therapeutic effect.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Hybrid Films Prepared from a Combination of Electrospinning and Casting for Offering a Dual-Phase Drug Release

et al. 2022

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One of the most important trends in developments in electrospinning is to combine itself with traditional materials production and transformation methods to take advantage of the unique properties of nanofibers. In this research, the single-fluid blending electrospinning process was combined with the casting film method to fabricate a medicated double-layer hybrid to provide a dual-phase drug controlled release profile, with ibuprofen (IBU) as a common model of a poorly water-soluble drug and ethyl cellulose (EC) and polyvinylpyrrolidone (PVP) K60 as the polymeric excipients. Electrospun medicated IBU-PVP nanofibers (F7), casting IBU-EC films (F8) and the double-layer hybrid films (DHFs, F9) with one layer of electrospun nanofibers containing IBU and PVP and the other layer of casting films containing IBU, EC and PVP, were prepared successfully. The SEM assessments demonstrated that F7 were in linear morphologies without beads or spindles, F8 were solid films, and F9 were composed of one porous fibrous layer and one solid layer. XRD and FTIR results verified that both EC and PVP were compatible with IBU. In vitro dissolution tests indicated that F7 were able to provide a pulsatile IBU release, F8 offered a typical drug sustained release, whereas F9 were able to exhibit a dual-phase controlled release with 40.3 ± 5.1% in the first phase for a pulsatile manner and the residues were released in an extended manner in the second phase. The DHFs from a combination of electrospinning and the casting method pave a new way for developing novel functional materials.

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“…The addition of sucralose with PVP in the shell section endows the core–shell nanohybrids with a favorable taste, and, in turn, could improve the patients’ compliance when exploited as oral, disintegrating films. Using the concept demonstrated here, many new, medicated materials can be further developed through the combination of cellulose-based gels and other types of polymer, e.g., biodegradable PLGA [ 80 ]. Particularly, those soluble polymers with a natural source will be able to play a more and more important role in developing new orodispersible drug delivery systems.…”

Section: Resultsmentioning

confidence: 99%

Electrospun Core (HPMC–Acetaminophen)–Shell (PVP–Sucralose) Nanohybrids for Rapid Drug Delivery

Liu

Zhang

Song

et al. 2022

Gels

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The gels of cellulose and its derivatives have a broad and deep application in pharmaceutics; however, limited attention has been paid to the influences of other additives on the gelation processes and their functional performances. In this study, a new type of electrospun core–shell nanohybrid was fabricated using modified, coaxial electrospinning which contained composites of hydroxypropyl methyl cellulose (HPMC) and acetaminophen (AAP) in the core sections and composites of PVP and sucralose in the shell sections. A series of characterizations demonstrated that the core–shell hybrids had linear morphology with clear core–shell nanostructures, and AAP and sucralose distributed in the core and shell section in an amorphous state separately due to favorable secondary interactions such as hydrogen bonding. Compared with the electrospun HPMC–AAP nanocomposites from single-fluid electrospinning of the core fluid, the core–shell nanohybrids were able to promote the water absorbance and HMPC gelation formation processes, which, in turn, ensured a faster release of AAP for potential orodispersible drug delivery applications. The mechanisms of the drug released from these nanofibers were demonstrated to be a combination of erosion and diffusion mechanisms. The presented protocols pave a way to adjust the properties of electrospun, cellulose-based, fibrous gels for better functional applications.

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Recent Advances in Poly(α-L-glutamic acid)-Based Nanomaterials for Drug Delivery

Cited by 75 publications

References 174 publications

Tuning Myogenesis by Controlling Gelatin Hydrogel Properties through Hydrogen Peroxide-Mediated Cross-Linking and Degradation

Tuning Myogenesis by Controlling Gelatin Hydrogel Properties through Hydrogen Peroxide-Mediated Cross-Linking and Degradation

Hybrid Films Prepared from a Combination of Electrospinning and Casting for Offering a Dual-Phase Drug Release

Electrospun Core (HPMC–Acetaminophen)–Shell (PVP–Sucralose) Nanohybrids for Rapid Drug Delivery

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