Recent Advances in the Construction of Flexible Sensors for Biomedical Applications

Zhou, Nan; Liu, Tianjiao; Wen, Bianying; Gong, Coucong; Wei, Gang; Su, Zhiqiang

doi:10.1002/biot.202000094

Cited by 34 publications

(16 citation statements)

References 96 publications

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“…provide a review of recent advances in the fabrication of flexible sensors taking advantage of functional nanomaterials. [ 1 ] Kargozar et al. provide a review on the role of quantum dots, with a focus on in vitro and in vivo studies, as well as a discussion about the clinical translation of these structures.…”

mentioning

confidence: 99%

Nanomaterials for Biomedical Applications

Oliveira¹,

Li²,

Choi³

et al. 2020

Biotechnology Journal

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mentioning

confidence: 99%

Nanomaterials for Biomedical Applications

Oliveira¹,

Li²,

Choi³

et al. 2020

Biotechnology Journal

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“…In recent years, due to their good ductility and conductivity, flexible electronic devices have attracted extensive attention and have been widely used in the fields of electronic skin, − soft robotics, , human–computer interaction, , and biosensor. − However, the substrate (e.g., flexible metals and polymer elastomers) and conductive (e.g., metals or conductive polymers) materials of the traditional flexible strain sensors, due to their large rigidity, poor tensile strength, and dispersibility, not only make users feel uncomfortable but also cannot accurately convert external mechanical signals into electrical ones. Therefore, the development of flexible wearable sensors with good mechanical property, excellent bending performance, monitoring sensitivity, and stability is the focus of current research.…”

Section: Introductionmentioning

confidence: 99%

Tough, Self-Adhesive, Antibacterial, and Recyclable Supramolecular Double Network Flexible Hydrogel Sensor Based on PVA/Chitosan/Cyclodextrin

Fan

Zhao

Ling

et al. 2022

Ind. Eng. Chem. Res.

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Hydrogel-based flexible sensors have attracted extensive attention of researchers due to their great application potential in soft robots, electronic skin, motion monitoring, and disease diagnosis. However, it is still a challenge for hydrogel-based flexible sensors to be integrated with good mechanical performance, sensitivity, self-adhesion, fatigue resistance, antibacterial activity, and recyclability. Here, a novel supramolecular polyoxymethylene cross-linking agent (PCD-Fc-CHO) was designed and synthesized by the host−guest interaction between poly(β-cyclodextrin) and ferrocene. Then, a double network (DN) hydrogel was prepared by a PVA crystallization domain via the freezethaw cycle method (first network) and Schiff base between PCD-Fc-CHO and chitosan (second network). The obtained DN hydrogel was immersed in the NaCl solution to form a conductive DN hydrogel. The resulting hydrogel has excellent mechanical properties [tensile (314%, 0.5 MPa), compress (50%, 0.663 MPa)], good fatigue resistance (stretching and compressing cycles at least five times), reliable conductivity (2.48 S/m), high sensitivity [gauge factor (GF) = 4.87], antibacterial, and recyclable properties. In addition, an industrially produced and low-cost plant polyphenol, black wattle tannin, was used for the first time to give the hydrogel good adhesion and repeated adhesion (at least ten times). The obtained hydrogel can be used as a flexible strain sensor to monitor both large movements (bending finger, wrist, elbow, arm, and knee) and micromovements (talking, smiling, blinking, blowing, frowning, and drinking) with high sensitivity and stability. It is noteworthy that the reshaped hydrogel also exhibits sensitive sensing performance, indicating that the hydrogel can be recycled. This work expanded the strategy for the design and preparation of multi-functional DN hydrogels and promoted the application of wearable, highly sensitive, fatigue resistance, antibacterial, and green hydrogel sensors.

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“…Moreover, for the implementation of a sensor for applications in food packaging, wearable devices, and medical devices, another imperative parameter is mechanical flexibility. 35,36 Herein, we provide an insight for the recent progress in the development of flexible sensors for the detection of hydrogen peroxide. Their performance is reviewed through assessing their sensing parameters, ease of fabrication, scalability, and their potential for real-world applications in monitoring environmental, health, and food safety conditions.…”

Section: Introductionmentioning

confidence: 99%

Flexible Sensors for Hydrogen Peroxide Detection: A Critical Review

Giaretta

Duan

Oveissi

et al. 2022

ACS Appl. Mater. Interfaces

100

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Hydrogen peroxide (H2O2) is a common chemical used in many industries and can be found in various biological environments, water, and air. Yet, H2O2 in a certain range of concentrations can be hazardous and toxic. Therefore, it is crucial to determine its concentration at different conditions for safety and diagnostic purposes. This review provides an insight about different types of sensors that have been developed for detection of H2O2. Their flexibility, stability, cost, detection limit, manufacturing, and challenges in their applications have been compared. More specifically the advantages and disadvantages of various flexible substrates that have been utilized for the design of H2O2 sensors were discussed. These substrates include carbonaceous substrates (e.g., reduced graphene oxide films, carbon cloth, carbon, and graphene fibers), polymeric substrates, paper, thin glass, and silicon wafers. Many of these substrates are often decorated with nanostructures composed of Pt, Au, Ag, MnO2, Fe3O4, or a conductive polymer to enhance the performance of sensors. The impact of these nanostructures on the sensing performance of resulting flexible H2O2 sensors has been reviewed in detail. In summary, the detection limits of these sensors are within the range of 100 nM–1 mM, which makes them potentially, but not necessarily, suitable for applications in health, food, and environmental monitoring. However, the required sample volume, cost, ease of manufacturing, and stability are often neglected compared to other detection parameters, which hinders sensors’ real-world application. Future perspectives on how to address some of the substrate limitations and examples of application-driven sensors are also discussed.

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Recent Advances in the Construction of Flexible Sensors for Biomedical Applications

Cited by 34 publications

References 96 publications

Nanomaterials for Biomedical Applications

Nanomaterials for Biomedical Applications

Tough, Self-Adhesive, Antibacterial, and Recyclable Supramolecular Double Network Flexible Hydrogel Sensor Based on PVA/Chitosan/Cyclodextrin

Flexible Sensors for Hydrogen Peroxide Detection: A Critical Review

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