Recent Advances of AIEgens for Targeted Imaging of Subcellular Organelles

Song, Nan; Xiao, Peihong; Ma, Ke; Kang, Miaomiao; Zhu, Wei; Huang, Jiachang; Wang, Dong; Tang, Ben Zhong

doi:10.1007/s40242-021-0430-1

Cited by 15 publications

(4 citation statements)

References 90 publications

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“…13 To generate the AIE effect inside the cancer cells, AIEgens have to target and aggregate in one specific organelle. 14 Mitochondria, as the energy sources in cells, play important roles in cell signaling, biosynthesis, and cell differentiation. 15,16 Due to the special structure of mitochondria, cation fragments help to realize the mitochondrial accumulation, as triphenylphosphonium (PPh 3 ), pyridinium and so on.…”

Section: Introductionmentioning

confidence: 99%

Fighting metallodrug resistance through alteration of drug metabolism and blockage of autophagic flux by mitochondria-targeting AIEgens

Lin

et al. 2022

Chem. Sci.

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Section: Introductionmentioning

confidence: 99%

Fighting metallodrug resistance through alteration of drug metabolism and blockage of autophagic flux by mitochondria-targeting AIEgens

Lin

et al. 2022

Chem. Sci.

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“…First, in the pure DPT-AuNC powder, the π–π stacking of DPT is strong. Similar to aggregation-induced quenching (ACQ)-type dyes, the π–π stacking is preferred for the emission of NCs. , Following the addition of small amounts of water ( c > CAC), restrained water molecules are immobilized on the DPT-AuNCs through the formation of robust water-bridged hydrogen-bonding motifs (Scheme ). The π–π stacking of DPT is weakened, and the photoluminescence is “triggered” along with the 1D nanofiber structures.…”

Section: Resultsmentioning

confidence: 99%

Luminescence Enhancement of a Gold Nanocluster Hydrogel Facilitated by Water for Erasable Water Writing and Visual Solvent Differentiation

Shen

Liu

et al. 2022

ACS Sustainable Chem. Eng.

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Gold nanoclusters (AuNCs) with an ultrasmall size have attracted enormous interest due to their unique luminescence properties. However, manipulating/improving the luminescence of AuNCs through a convenient method is still challenging. Herein, effective enhancement of emission by simply using water is reported for the AuNCs stabilized by 4,6-diamino-2-pyrimidinethiol (DPT). The DPT-AuNCs could aggregate into a hydrogel in aqueous systems, accompanied with luminescence enhancement (the quantum yield increased from 0.36 to 3.07%). However, the xerogel obtained by freeze-drying was non-luminescent. Addition of water to the xerogel could trigger the emission again. Differential scanning calorimetry, X-ray diffraction, and theoretical calculations reveal that water-bridged hydrogen bonds play crucial roles in the emission of DPT-AuNCs. Furthermore, the water-sensitive luminescence of DPT-AuNCs was applied for developing erasable water writing materials and for visual differentiation of solvents (e.g., protonic organic solvents, non-protonic organic solvents, and water). This study offers a green, cost-effective, and convenient strategy for enhancing the luminescence properties of AuNCs, reveals the crucial role of water molecules in the emission of AuNCs, and presents an application in optoelectronic functional materials.

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“…As a result, AIE‐active bioprobes with subcellular targeting capabilities have been extensively studied for visualizing subcellular structures and monitoring biological processes. [ 126 ] Mitochondria are the central hub for cellular energy metabolism, featuring a highly dynamic structure. The abnormal dynamic changes of mitochondria are closely associated with diseases like Alzheimer's disease, Parkinson's disease, metabolic disorders, and cancer.…”

Section: Biomedical Applications Of Nir‐aie Materialsmentioning

confidence: 99%

Near‐infrared aggregation‐induced emission materials: Bibliometric analysis and their application in biomedical field

He,

Wang,

Zhao

et al. 2024

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Aggregation‐induced emission (AIE) is an intriguing photophysical phenomenon, where specific materials exhibit a remarkable surge in luminescence when brought together in non‐ideal solvents or within a solid matrix. Since the concept of AIE was first introduced in 2001, numerous advanced applications have been gradually explored across various domains, including optics, electronics, energy, and the life sciences. Of particular note is the growing interest in the application of AIE systems with near‐infrared (NIR) emissive feature in the field of biomedicine, encompassing detection, imaging, and therapeutic interventions. Notably, bibliometric analysis serves as a valuable tool to provide researchers with a comprehensive understanding of research achievements and developmental trends in specific fields, which is crucial for academic research. Herein, we present a general bibliometric overview spanning two decades of NIR‐AIE development. With the assistance of core scientific databases and various bibliometric software tools, we conducted a systematic analysis of annual publications and citations, the most influential countries/regions, leading authors, journals, and institutions, as well as the hot topics related to NIR applications and forward‐looking predictions. Furthermore, the application of AIE with NIR properties in the biomedical field is also systematically reviewed.

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Recent Advances of AIEgens for Targeted Imaging of Subcellular Organelles

Cited by 15 publications

References 90 publications

Fighting metallodrug resistance through alteration of drug metabolism and blockage of autophagic flux by mitochondria-targeting AIEgens

Fighting metallodrug resistance through alteration of drug metabolism and blockage of autophagic flux by mitochondria-targeting AIEgens

Luminescence Enhancement of a Gold Nanocluster Hydrogel Facilitated by Water for Erasable Water Writing and Visual Solvent Differentiation

Near‐infrared aggregation‐induced emission materials: Bibliometric analysis and their application in biomedical field

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