Recent advances of lanthanide-doped upconversion nanoparticles for biological applications

Li, Hui; Wang, Xin; Huang, Dingxin; Chen, Guanying

doi:10.1088/1361-6528/ab4f36

Cited by 70 publications

(54 citation statements)

References 206 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus far, five different mechanisms can lead to the two or more photons absorption processes in lanthanide-doped inorganic nanoparticles (Figure 1a): excited state absorption (ESA), energy transfer upconversion (ETU), cooperative energy transfer (CET), photon avalanche (PA) and energy migration upconversion (EMU). [46][47][48][49][50] Due to the excited states have an comparatively long lifetime, single excited lanthanide ions may orderly take in two or more photons of suitable energy at relatively low excitation densities which help them to reach a higher excited state inducing the output emission wavelength is shorter than the pump one. By selecting the proper type of doping lanthanide ions in within one UCNP, a broad range of emission wavelengths in the UV-NIR spectral region, which are helpful in various application fields could be modulated (Figure 1b).…”

Section: Properties Of Oucnpsmentioning

confidence: 99%

Orthogonal Emissive Upconversion Nanoparticles: Material Design and Applications

Zhang

2021

Small

View full text Add to dashboard Cite

Upconversion nanoparticles (UCNPs) have gone beyond traditional fluorophores in a lot of fields due to the outstanding features such as sharp excitation and emission bands, chemical and photo stability of high quality, low auto fluorescence, and high tissue permeation depth of the near‐infrared irradiation light used for excitation. Conventional UCNPs carrying single/multiple emissions under a single excitation wavelength can be only employed in concurrent activation, orthogonal emissive upconversion nanoparticles (OUCNPs) with the emissions, a kind of luminescence reliant on excitation, in which by switching the external excitation different lanthanide activators can adopt independent way to control the emission, is more like an ideal UCNPs nanoplatform which can switch their activated emissions depending upon the different application for which it is used at the right time when necessary. This review summaries what has been achieved on the synthesis optimization of designed OUCNPs in recent years and sums up various applications including bioimaging, photo‐switching, and programmable control process. And also, the limitations OUCNPs face, and the efforts that have been made to overcome these limitations are discussed.

show abstract

Section: Properties Of Oucnpsmentioning

confidence: 99%

Orthogonal Emissive Upconversion Nanoparticles: Material Design and Applications

Zhang

2021

Small

View full text Add to dashboard Cite

show abstract

“…[ 92 ] With an increase in doping concentration of Ln 3+ ions, the distance between them becomes shorter that increases the rate of nonradiative deactivation, including cross‐relaxation (CR), the phonon‐assisted energy transfer, and the surface quenching resulted from the energy migration (EM) of absorbed energy from internal dopants to surface quenchers ( Figure a). [ 26,93,94 ] As a result, both the absorption ability of sensitizers and the emission capacity of activators are substantially curbed by the dopant concentrations. Thus, the exclusion of the strict concentration limit for doped Ln 3+ ions (either the sensitizer or the activator) is critical for the increase in the UCNPs brightness.…”

Section: Lanthanide‐doped Nir Nanoparticlesmentioning

confidence: 99%

Lanthanide‐Doped Near‐Infrared Nanoparticles for Biophotonics

et al. 2020

Self Cite

View full text Add to dashboard Cite

Light in the near‐infrared (NIR) spectral region is increasingly utilized in bioapplications, providing deeper penetration in biological tissues owing to the lower absorption and scattering in comparison with light in the visible range. Lanthanide‐doped luminescent nanoparticles with excitation and/or emission in the NIR range have recently attracted tremendous attention as one of the prime candidates for noninvasive biological applications due to their unique optical properties, such as large Stokes shift, spectrally sharp luminescence emissions, long luminescence lifetimes, and excellent photostability. Herein, recent advances of lanthanide‐doped nanoparticles with NIR upconversion or downshifting luminescence and their uses in cutting‐edge biophotonic applications are presented. A set of efficient strategies for overcoming the fundamental limit of low luminescence brightness of lanthanide‐doped nanoparticles is introduced. An in‐depth literature review of their state‐of‐art biophotonics applications is also included, showing their superiority for high‐resolution imaging, single‐nanoparticle‐level detection, and efficacy for tissue‐penetrating diagnostics and therapeutics.

show abstract

“…98 Therefore, studies need to be performed to characterize in-vitro cytotoxicity and long-term toxicity in vivo. 99 UCNPs are usually modified by surface coating, including polyvinylpyrrolidone (PVP), polyethylenimine (PEI) and SiO 2 , 47 which generate UCNPs with stability, safety and biocompatibility. There are well used methods for detecting in-vitro cytotoxicity of UCNPs, including MTT, MTS and CCK-8 assays.…”

Section: Nano-toxicity Of Ucnps In Vitro and In Vivomentioning

confidence: 99%

“…Functionalized watersoluble UCNPs with well-defined concentration and incubation time, caused very low cytotoxicity in Hela, glioma U87MG and MCF-7 cells. 99,100 Moreover, it is necessary…”

Section: Nano-toxicity Of Ucnps In Vitro and In Vivomentioning

confidence: 99%

<p>Up-Conversion Luminescent Nanoparticles for Molecular Imaging, Cancer Diagnosis and Treatment</p>

Wei

et al. 2020

IJN

View full text Add to dashboard Cite

In the past few years, we have witnessed great development and application potential of various up-conversion luminescent nanoparticles (UCNPs) in the nanomedicine field. Based on the unique luminescent mechanism of UCNPs and the distinguishable features of cancer biomarkers and the microenvironment, an increasing number of smart UCNPs nanoprobes have been designed and widely applied to molecular imaging, cancer diagnosis, and treatment. Considerable technological success has been achieved, but the main obstacles to oncology nanomedicine is becoming an incomplete understanding of nano-bio interactions, the challenges regarding chemistry manufacturing and controls required for clinical translation and so on. This review highlights the progress of the design principles, synthesis and surface functionalization preparation, underlying applications and challenges of UCNPs-based probes for cancer bioimaging, diagnosis and treatment that capitalize on our growing understanding of tumor biology and smart nano-devices for accelerating the commercialization of UCNPs.

show abstract

Recent advances of lanthanide-doped upconversion nanoparticles for biological applications

Cited by 70 publications

References 206 publications

Orthogonal Emissive Upconversion Nanoparticles: Material Design and Applications

Orthogonal Emissive Upconversion Nanoparticles: Material Design and Applications

Lanthanide‐Doped Near‐Infrared Nanoparticles for Biophotonics

<p>Up-Conversion Luminescent Nanoparticles for Molecular Imaging, Cancer Diagnosis and Treatment</p>

Contact Info

Product

Resources

About